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Assessment of Appropriateness of Antimicrobial Therapy in Resource-Constrained Settings: Development and Piloting of a Novel Tool—AmRAT

Inappropriate antimicrobial prescribing is considered to be the leading cause of high burden of antimicrobial resistance (AMR) in resource-constrained lower- and middle-income countries. Under its global action plan, the World Health Organization has envisaged tackling the AMR threat through promoti...

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Autores principales: Kakkar, Ashish Kumar, Shafiq, Nusrat, Sahni, Neeru, Mohindra, Ritin, Kaur, Navjot, Gamad, Nanda, Panditrao, Aditi, Kondal, Dimple, Malhotra, Samir, Kumar M, Praveen, Rohilla, Rachna, Bhattacharjee, Samiksha, Kumar, Ankit, Bhandari, Ritika Kondel, Pandey, Avaneesh Kumar, Rather, Imraan, Mothsara, Chakrant, Harish, Cvn, Belavagi, Devaraj, Vishwas, Gopal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923130/
https://www.ncbi.nlm.nih.gov/pubmed/33669509
http://dx.doi.org/10.3390/antibiotics10020200
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author Kakkar, Ashish Kumar
Shafiq, Nusrat
Sahni, Neeru
Mohindra, Ritin
Kaur, Navjot
Gamad, Nanda
Panditrao, Aditi
Kondal, Dimple
Malhotra, Samir
Kumar M, Praveen
Rohilla, Rachna
Bhattacharjee, Samiksha
Kumar, Ankit
Bhandari, Ritika Kondel
Pandey, Avaneesh Kumar
Rather, Imraan
Mothsara, Chakrant
Harish, Cvn
Belavagi, Devaraj
Vishwas, Gopal
author_facet Kakkar, Ashish Kumar
Shafiq, Nusrat
Sahni, Neeru
Mohindra, Ritin
Kaur, Navjot
Gamad, Nanda
Panditrao, Aditi
Kondal, Dimple
Malhotra, Samir
Kumar M, Praveen
Rohilla, Rachna
Bhattacharjee, Samiksha
Kumar, Ankit
Bhandari, Ritika Kondel
Pandey, Avaneesh Kumar
Rather, Imraan
Mothsara, Chakrant
Harish, Cvn
Belavagi, Devaraj
Vishwas, Gopal
author_sort Kakkar, Ashish Kumar
collection PubMed
description Inappropriate antimicrobial prescribing is considered to be the leading cause of high burden of antimicrobial resistance (AMR) in resource-constrained lower- and middle-income countries. Under its global action plan, the World Health Organization has envisaged tackling the AMR threat through promotion of rational antibiotic use among prescribers. Given the lack of consensus definitions and other associated challenges, we sought to devise and validate an Antimicrobial Rationality Assessment Tool—AmRAT—for standardizing the assessment of appropriateness of antimicrobial prescribing. A consensus algorithm was developed by a multidisciplinary team consisting of intensivists, internal medicine practitioners, clinical pharmacologists, and infectious disease experts. The tool was piloted by 10 raters belonging to three groups of antimicrobial stewardship (AMS) personnel: Master of Pharmacology (M.Sc.) (n = 3, group A), Doctor of Medicine (MD) residents (n = 3, group B), and DM residents in clinical pharmacology (n = 4, group C) using retrospective patient data from 30 audit and feedback forms collected as part of an existing AMS program. Percentage agreement and the kappa (κ) coefficients were used to measure inter-rater agreements amongst themselves and with expert opinion. Sensitivity and specificity estimates were analyzed comparing their assessments against the gold standard. For the overall assessment of rationality, the mean percent agreement with experts was 76.7% for group A, 68.9% for group B, and 77.5% for group C. The kappa values indicated moderate agreement for all raters in group A (κ 0.47–0.57), and fair to moderate in group B (κ 0.22–0.46) as well as group C (κ 0.37–0.60). Sensitivity and specificity for the same were 80% and 68.6%, respectively. Though evaluated by raters with diverse educational background and variable AMS experience in this pilot study, our tool demonstrated high percent agreement and good sensitivity and specificity, assuring confidence in its utility for assessing appropriateness of antimicrobial prescriptions in resource-constrained healthcare environments.
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spelling pubmed-79231302021-03-03 Assessment of Appropriateness of Antimicrobial Therapy in Resource-Constrained Settings: Development and Piloting of a Novel Tool—AmRAT Kakkar, Ashish Kumar Shafiq, Nusrat Sahni, Neeru Mohindra, Ritin Kaur, Navjot Gamad, Nanda Panditrao, Aditi Kondal, Dimple Malhotra, Samir Kumar M, Praveen Rohilla, Rachna Bhattacharjee, Samiksha Kumar, Ankit Bhandari, Ritika Kondel Pandey, Avaneesh Kumar Rather, Imraan Mothsara, Chakrant Harish, Cvn Belavagi, Devaraj Vishwas, Gopal Antibiotics (Basel) Article Inappropriate antimicrobial prescribing is considered to be the leading cause of high burden of antimicrobial resistance (AMR) in resource-constrained lower- and middle-income countries. Under its global action plan, the World Health Organization has envisaged tackling the AMR threat through promotion of rational antibiotic use among prescribers. Given the lack of consensus definitions and other associated challenges, we sought to devise and validate an Antimicrobial Rationality Assessment Tool—AmRAT—for standardizing the assessment of appropriateness of antimicrobial prescribing. A consensus algorithm was developed by a multidisciplinary team consisting of intensivists, internal medicine practitioners, clinical pharmacologists, and infectious disease experts. The tool was piloted by 10 raters belonging to three groups of antimicrobial stewardship (AMS) personnel: Master of Pharmacology (M.Sc.) (n = 3, group A), Doctor of Medicine (MD) residents (n = 3, group B), and DM residents in clinical pharmacology (n = 4, group C) using retrospective patient data from 30 audit and feedback forms collected as part of an existing AMS program. Percentage agreement and the kappa (κ) coefficients were used to measure inter-rater agreements amongst themselves and with expert opinion. Sensitivity and specificity estimates were analyzed comparing their assessments against the gold standard. For the overall assessment of rationality, the mean percent agreement with experts was 76.7% for group A, 68.9% for group B, and 77.5% for group C. The kappa values indicated moderate agreement for all raters in group A (κ 0.47–0.57), and fair to moderate in group B (κ 0.22–0.46) as well as group C (κ 0.37–0.60). Sensitivity and specificity for the same were 80% and 68.6%, respectively. Though evaluated by raters with diverse educational background and variable AMS experience in this pilot study, our tool demonstrated high percent agreement and good sensitivity and specificity, assuring confidence in its utility for assessing appropriateness of antimicrobial prescriptions in resource-constrained healthcare environments. MDPI 2021-02-19 /pmc/articles/PMC7923130/ /pubmed/33669509 http://dx.doi.org/10.3390/antibiotics10020200 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kakkar, Ashish Kumar
Shafiq, Nusrat
Sahni, Neeru
Mohindra, Ritin
Kaur, Navjot
Gamad, Nanda
Panditrao, Aditi
Kondal, Dimple
Malhotra, Samir
Kumar M, Praveen
Rohilla, Rachna
Bhattacharjee, Samiksha
Kumar, Ankit
Bhandari, Ritika Kondel
Pandey, Avaneesh Kumar
Rather, Imraan
Mothsara, Chakrant
Harish, Cvn
Belavagi, Devaraj
Vishwas, Gopal
Assessment of Appropriateness of Antimicrobial Therapy in Resource-Constrained Settings: Development and Piloting of a Novel Tool—AmRAT
title Assessment of Appropriateness of Antimicrobial Therapy in Resource-Constrained Settings: Development and Piloting of a Novel Tool—AmRAT
title_full Assessment of Appropriateness of Antimicrobial Therapy in Resource-Constrained Settings: Development and Piloting of a Novel Tool—AmRAT
title_fullStr Assessment of Appropriateness of Antimicrobial Therapy in Resource-Constrained Settings: Development and Piloting of a Novel Tool—AmRAT
title_full_unstemmed Assessment of Appropriateness of Antimicrobial Therapy in Resource-Constrained Settings: Development and Piloting of a Novel Tool—AmRAT
title_short Assessment of Appropriateness of Antimicrobial Therapy in Resource-Constrained Settings: Development and Piloting of a Novel Tool—AmRAT
title_sort assessment of appropriateness of antimicrobial therapy in resource-constrained settings: development and piloting of a novel tool—amrat
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923130/
https://www.ncbi.nlm.nih.gov/pubmed/33669509
http://dx.doi.org/10.3390/antibiotics10020200
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