Cargando…

Peripheral blood mononuclear cells preferentially activate 11-oxygenated androgens

OBJECTIVE: Androgens are important modulators of immune cell function. The local generation of active androgens from circulating precursors is an important mediator of androgen action in peripheral target cells or tissues. We aimed to characterize the activation of classic and 11-oxygenated androgen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schiffer, Lina, Bossey, Alicia, Kempegowda, Punith, Taylor, Angela E, Akerman, Ildem, Scheel-Toellner, Dagmar, Storbeck, Karl-Heinz, Arlt, Wiebke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2021
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923147/ https://www.ncbi.nlm.nih.gov/pubmed/33444228 http://dx.doi.org/10.1530/EJE-20-1077

Ejemplares similares

MECHANISMS IN ENDOCRINOLOGY: The sexually dimorphic role of androgens in human metabolic disease
por: Schiffer, Lina, et al.
Publicado: (2017)

11-Oxygenated C19 Steroids Are the Predominant Androgens in Polycystic Ovary Syndrome
por: O’Reilly, Michael W., et al.
Publicado: (2016)

Intracrine androgen biosynthesis, metabolism and action revisited
por: Schiffer, Lina, et al.
Publicado: (2018)

MON-203 Local Activation of 11-Oxygenated Androgens by AKR1C3 Is the Predominant Source of Androgens in Human Female Adipose Tissue
por: Schiffer, Lina, et al.
Publicado: (2019)

Implicating androgen excess in propagating metabolic disease in polycystic ovary syndrome
por: Kempegowda, Punith, et al.
Publicado: (2020)

11-Oxygenated Estrogens Are a Novel Class of Human Estrogens but Do not Contribute to the Circulating Estrogen Pool
por: Barnard, Lise, et al.
Publicado: (2020)

AKR1C3-Mediated Adipose Androgen Generation Drives Lipotoxicity in Women With Polycystic Ovary Syndrome
por: O’Reilly, Michael W., et al.
Publicado: (2017)

Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review
por: Schiffer, Lina, et al.
Publicado: (2019)

11-Ketotestosterone and 11-Ketodihydrotestosterone in Castration Resistant Prostate Cancer: Potent Androgens Which Can No Longer Be Ignored
por: Pretorius, Elzette, et al.
Publicado: (2016)

Concerns and expectations in women with polycystic ovary syndrome vary across age and ethnicity: findings from PCOS Pearls Study
por: Elghobashy, Mirna, et al.
Publicado: (2023)

Appraising Unmet Needs and Misinformation Spread About Polycystic Ovary Syndrome in 85,872 YouTube Comments Over 12 Years: Big Data Infodemiology Study
por: Malhotra, Kashish, et al.
Publicado: (2023)

Steroid Metabolome Analysis in Disorders of Adrenal Steroid Biosynthesis and Metabolism
por: Storbeck, Karl-Heinz, et al.
Publicado: (2019)

Modified-Release and Conventional Glucocorticoids and Diurnal Androgen Excretion in Congenital Adrenal Hyperplasia
por: Jones, Christopher M., et al.
Publicado: (2016)

A systematic review of lived experiences of people with polycystic ovary syndrome highlights the need for holistic care and co-creation of educational resources
por: Lau, Gar Mun, et al.
Publicado: (2022)

SIMBA: using Kolb’s learning theory in simulation-based learning to improve participants’ confidence
por: Davitadze, Meri, et al.
Publicado: (2022)

Polycystic ovary syndrome and risk of adverse obstetric outcomes: a retrospective population-based matched cohort study in England
por: Subramanian, Anuradhaa, et al.
Publicado: (2022)

OR09-5 Importance of Islet Intracrinology for Glucose-Stimulated Insulin Secretion (GSIS) in the Male
por: Xu, Weiwei, et al.
Publicado: (2019)

11-Ketotestosterone is the predominant active androgen in prostate cancer patients after castration
por: Snaterse, Gido, et al.
Publicado: (2021)

DORMEX(®)-hydrogen cyanamide poisoning
por: Sheshadri, Sunil Holavanahalli, et al.
Publicado: (2011)

SAT-LB002 Steroid Metabolome Analysis Reveals 11-Ketotestosterone as the Most Abundant Androgen in Castration-Resistant Prostate Cancer Patients on Second-Line Therapies
por: Snaterse, Gido, et al.
Publicado: (2019)

Cytokine mRNA profiling identifies B cells as a major source of RANKL in rheumatoid arthritis
por: Yeo, Lorraine, et al.
Publicado: (2011)

Top 100 #PCOS influencers: Understanding who, why and how online content for PCOS is influenced
por: Elhariry, Maiar, et al.
Publicado: (2022)

Identifying the challenges and opportunities of PCOS awareness month by analysing its global digital impact
por: Malhotra, Kashish, et al.
Publicado: (2023)

Bayesian inference of origin firing time distributions, origin interference and licencing probabilities from Next Generation Sequencing data
por: Bazarova, Alina, et al.
Publicado: (2019)

New Developments in Transcriptomic Analysis of Synovial Tissue
por: Carr, Hayley L., et al.
Publicado: (2020)

Incidental finding of lipaemia retinalis on diabetic retinal screening
por: Kempegowda, Punith, et al.
Publicado: (2021)

Membrane androgen binding sites are preferentially expressed in human prostate carcinoma cells
por: Stathopoulos, Efstathios N, et al.
Publicado: (2003)

11β-Hydroxyandrostenedione Returns to the Steroid Arena: Biosynthesis, Metabolism and Function
por: Bloem, Liezl M., et al.
Publicado: (2013)

βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function
por: Arnes, Luis, et al.
Publicado: (2016)

Causes, Patterns, and Severity of Androgen Excess in 1205 Consecutively Recruited Women
por: Elhassan, Yasir S, et al.
Publicado: (2018)

Khat and stroke
por: Kulkarni, Sanjay V., et al.
Publicado: (2012)

Significance of serum procalcitonin in sepsis
por: Sudhir, Uchil, et al.
Publicado: (2011)

Diabetic myonecrosis: an uncommon diabetic complication
por: Kempegowda, Punith, et al.
Publicado: (2019)

The Steroid Metabolome in the Isolated Ovarian Follicle and Its Response to Androgen Exposure and Antagonism
por: Lebbe, Marie, et al.
Publicado: (2017)

Simulation via instant messaging-Birmingham advance (SIMBA) model helped improve clinicians’ confidence to manage cases in diabetes and endocrinology
por: Melson, Eka, et al.
Publicado: (2020)

Adrenal insufficiency from steroid-containing complementary therapy: importance of detailed history
por: Kempegowda, Punith, et al.
Publicado: (2019)

Abiraterone switches castration‐resistant prostate cancer dependency from adrenal androgens towards androgen receptor variants and glucocorticoid receptor signalling
por: Moll, J. Matthijs, et al.
Publicado: (2022)

Reply to Flück et al.: Alternative androgen pathway biosynthesis drives fetal female virilization in P450 oxidoreductase deficiency
por: Reisch, Nicole, et al.
Publicado: (2020)

Cytotoxic Activity of Peripheral Blood Mononuclear Leukocytes, Activated by Interleukin-2/β-Cyclodextrin Nanocomposition against Androgen Receptor-Negative Prostate Cancers
por: Anisimova, Natalia Yu., et al.
Publicado: (2011)

Concomitant Mutations in the P450 Oxidoreductase and Androgen Receptor Genes Presenting with 46,XY Disordered Sex Development and Androgenization at Adrenarche
por: Idkowiak, Jan, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_5jv9a1bejcc457pp09qlemaolm