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The Transcriptional Regulatory Network of Corynebacterium pseudotuberculosis
Corynebacterium pseudotuberculosis is a Gram-positive, facultative intracellular, pathogenic bacterium that infects several different hosts, yielding serious economic losses in livestock farming. It causes several diseases including oedematous skin disease (OSD) in buffaloes, ulcerative lymphangitis...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923171/ https://www.ncbi.nlm.nih.gov/pubmed/33671149 http://dx.doi.org/10.3390/microorganisms9020415 |
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author | Parise, Doglas Teixeira Dornelles Parise, Mariana Pinto Gomide, Anne Cybelle Figueira Aburjaile, Flávia Bentes Kato, Rodrigo Salgado-Albarrán, Marisol Tauch, Andreas Ariston de Carvalho Azevedo, Vasco Baumbach, Jan |
author_facet | Parise, Doglas Teixeira Dornelles Parise, Mariana Pinto Gomide, Anne Cybelle Figueira Aburjaile, Flávia Bentes Kato, Rodrigo Salgado-Albarrán, Marisol Tauch, Andreas Ariston de Carvalho Azevedo, Vasco Baumbach, Jan |
author_sort | Parise, Doglas |
collection | PubMed |
description | Corynebacterium pseudotuberculosis is a Gram-positive, facultative intracellular, pathogenic bacterium that infects several different hosts, yielding serious economic losses in livestock farming. It causes several diseases including oedematous skin disease (OSD) in buffaloes, ulcerative lymphangitis (UL) in horses, and caseous lymphadenitis (CLA) in sheep, goats and humans. Despite its economic and medical-veterinary importance, our understanding concerning this organism’s transcriptional regulatory mechanisms is still limited. Here, we review the state of the art knowledge on transcriptional regulatory mechanisms of this pathogenic species, covering regulatory interactions mediated by two-component systems, transcription factors and sigma factors. Key transcriptional regulatory players involved in virulence and pathogenicity of C. pseudotuberculosis, such as the PhoPR system and DtxR, are in the focus of this review, as these regulators are promising targets for future vaccine design and drug development. We conclude that more experimental studies are needed to further understand the regulatory repertoire of this important zoonotic pathogen, and that regulators are promising targets for future vaccine design and drug development. |
format | Online Article Text |
id | pubmed-7923171 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79231712021-03-03 The Transcriptional Regulatory Network of Corynebacterium pseudotuberculosis Parise, Doglas Teixeira Dornelles Parise, Mariana Pinto Gomide, Anne Cybelle Figueira Aburjaile, Flávia Bentes Kato, Rodrigo Salgado-Albarrán, Marisol Tauch, Andreas Ariston de Carvalho Azevedo, Vasco Baumbach, Jan Microorganisms Review Corynebacterium pseudotuberculosis is a Gram-positive, facultative intracellular, pathogenic bacterium that infects several different hosts, yielding serious economic losses in livestock farming. It causes several diseases including oedematous skin disease (OSD) in buffaloes, ulcerative lymphangitis (UL) in horses, and caseous lymphadenitis (CLA) in sheep, goats and humans. Despite its economic and medical-veterinary importance, our understanding concerning this organism’s transcriptional regulatory mechanisms is still limited. Here, we review the state of the art knowledge on transcriptional regulatory mechanisms of this pathogenic species, covering regulatory interactions mediated by two-component systems, transcription factors and sigma factors. Key transcriptional regulatory players involved in virulence and pathogenicity of C. pseudotuberculosis, such as the PhoPR system and DtxR, are in the focus of this review, as these regulators are promising targets for future vaccine design and drug development. We conclude that more experimental studies are needed to further understand the regulatory repertoire of this important zoonotic pathogen, and that regulators are promising targets for future vaccine design and drug development. MDPI 2021-02-17 /pmc/articles/PMC7923171/ /pubmed/33671149 http://dx.doi.org/10.3390/microorganisms9020415 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Parise, Doglas Teixeira Dornelles Parise, Mariana Pinto Gomide, Anne Cybelle Figueira Aburjaile, Flávia Bentes Kato, Rodrigo Salgado-Albarrán, Marisol Tauch, Andreas Ariston de Carvalho Azevedo, Vasco Baumbach, Jan The Transcriptional Regulatory Network of Corynebacterium pseudotuberculosis |
title | The Transcriptional Regulatory Network of Corynebacterium pseudotuberculosis |
title_full | The Transcriptional Regulatory Network of Corynebacterium pseudotuberculosis |
title_fullStr | The Transcriptional Regulatory Network of Corynebacterium pseudotuberculosis |
title_full_unstemmed | The Transcriptional Regulatory Network of Corynebacterium pseudotuberculosis |
title_short | The Transcriptional Regulatory Network of Corynebacterium pseudotuberculosis |
title_sort | transcriptional regulatory network of corynebacterium pseudotuberculosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923171/ https://www.ncbi.nlm.nih.gov/pubmed/33671149 http://dx.doi.org/10.3390/microorganisms9020415 |
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