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Targeted Hybrid Nanocarriers as a System Enhancing the Skin Structure
The skin is constantly exposed to external and internal factors that disturb its function. In this work, two nanosystems-levan nanoparticles and a surfactin-stabilized nanoemulsion were preserved (tested for microbial growth) and characterized (size, polydispersity, Zeta potential, and stability). T...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923190/ https://www.ncbi.nlm.nih.gov/pubmed/33670519 http://dx.doi.org/10.3390/molecules26041063 |
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author | Lewińska, Agnieszka Domżał-Kędzia, Marta Kierul, Kinga Bochynek, Michał Pannert, Dominika Nowaczyk, Piotr Łukaszewicz, Marcin |
author_facet | Lewińska, Agnieszka Domżał-Kędzia, Marta Kierul, Kinga Bochynek, Michał Pannert, Dominika Nowaczyk, Piotr Łukaszewicz, Marcin |
author_sort | Lewińska, Agnieszka |
collection | PubMed |
description | The skin is constantly exposed to external and internal factors that disturb its function. In this work, two nanosystems-levan nanoparticles and a surfactin-stabilized nanoemulsion were preserved (tested for microbial growth) and characterized (size, polydispersity, Zeta potential, and stability). The nanosystems were introduced in the model formulations-cream, tonic, and gel, and confirmed by TEM. The analysis showed that nanoemulsion has a spherical morphology and size 220–300 nm, while levan nanoparticles had irregular shapes independently of the use of matrix and with particle size (130–260 nm). Additionally, we examined the antiradical effect of levan nanoparticles and nanoemulsion in the prototype of formulations by scavenging DPPH (2,2-diphenyl-1-picrylhydrazyl; EPR spectroscopy). The model cream with both nanosystems and the whole range of products with nanosystems were evaluated in vivo for hydration, elasticity, smoothness, wrinkles and vascular lesions, discoloration, respectively. The cream improved skin condition in all tested parameters in at least 50% of volunteers. The use of more comprehensive care, additionally consisting of a tonic and gel, reduced the previously existing skin discoloration to 10.42 ± 0.58%. The presented prototype formulations are promising in improving skin conditions. |
format | Online Article Text |
id | pubmed-7923190 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79231902021-03-03 Targeted Hybrid Nanocarriers as a System Enhancing the Skin Structure Lewińska, Agnieszka Domżał-Kędzia, Marta Kierul, Kinga Bochynek, Michał Pannert, Dominika Nowaczyk, Piotr Łukaszewicz, Marcin Molecules Article The skin is constantly exposed to external and internal factors that disturb its function. In this work, two nanosystems-levan nanoparticles and a surfactin-stabilized nanoemulsion were preserved (tested for microbial growth) and characterized (size, polydispersity, Zeta potential, and stability). The nanosystems were introduced in the model formulations-cream, tonic, and gel, and confirmed by TEM. The analysis showed that nanoemulsion has a spherical morphology and size 220–300 nm, while levan nanoparticles had irregular shapes independently of the use of matrix and with particle size (130–260 nm). Additionally, we examined the antiradical effect of levan nanoparticles and nanoemulsion in the prototype of formulations by scavenging DPPH (2,2-diphenyl-1-picrylhydrazyl; EPR spectroscopy). The model cream with both nanosystems and the whole range of products with nanosystems were evaluated in vivo for hydration, elasticity, smoothness, wrinkles and vascular lesions, discoloration, respectively. The cream improved skin condition in all tested parameters in at least 50% of volunteers. The use of more comprehensive care, additionally consisting of a tonic and gel, reduced the previously existing skin discoloration to 10.42 ± 0.58%. The presented prototype formulations are promising in improving skin conditions. MDPI 2021-02-18 /pmc/articles/PMC7923190/ /pubmed/33670519 http://dx.doi.org/10.3390/molecules26041063 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lewińska, Agnieszka Domżał-Kędzia, Marta Kierul, Kinga Bochynek, Michał Pannert, Dominika Nowaczyk, Piotr Łukaszewicz, Marcin Targeted Hybrid Nanocarriers as a System Enhancing the Skin Structure |
title | Targeted Hybrid Nanocarriers as a System Enhancing the Skin Structure |
title_full | Targeted Hybrid Nanocarriers as a System Enhancing the Skin Structure |
title_fullStr | Targeted Hybrid Nanocarriers as a System Enhancing the Skin Structure |
title_full_unstemmed | Targeted Hybrid Nanocarriers as a System Enhancing the Skin Structure |
title_short | Targeted Hybrid Nanocarriers as a System Enhancing the Skin Structure |
title_sort | targeted hybrid nanocarriers as a system enhancing the skin structure |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923190/ https://www.ncbi.nlm.nih.gov/pubmed/33670519 http://dx.doi.org/10.3390/molecules26041063 |
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