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Targeted Hybrid Nanocarriers as a System Enhancing the Skin Structure

The skin is constantly exposed to external and internal factors that disturb its function. In this work, two nanosystems-levan nanoparticles and a surfactin-stabilized nanoemulsion were preserved (tested for microbial growth) and characterized (size, polydispersity, Zeta potential, and stability). T...

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Autores principales: Lewińska, Agnieszka, Domżał-Kędzia, Marta, Kierul, Kinga, Bochynek, Michał, Pannert, Dominika, Nowaczyk, Piotr, Łukaszewicz, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923190/
https://www.ncbi.nlm.nih.gov/pubmed/33670519
http://dx.doi.org/10.3390/molecules26041063
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author Lewińska, Agnieszka
Domżał-Kędzia, Marta
Kierul, Kinga
Bochynek, Michał
Pannert, Dominika
Nowaczyk, Piotr
Łukaszewicz, Marcin
author_facet Lewińska, Agnieszka
Domżał-Kędzia, Marta
Kierul, Kinga
Bochynek, Michał
Pannert, Dominika
Nowaczyk, Piotr
Łukaszewicz, Marcin
author_sort Lewińska, Agnieszka
collection PubMed
description The skin is constantly exposed to external and internal factors that disturb its function. In this work, two nanosystems-levan nanoparticles and a surfactin-stabilized nanoemulsion were preserved (tested for microbial growth) and characterized (size, polydispersity, Zeta potential, and stability). The nanosystems were introduced in the model formulations-cream, tonic, and gel, and confirmed by TEM. The analysis showed that nanoemulsion has a spherical morphology and size 220–300 nm, while levan nanoparticles had irregular shapes independently of the use of matrix and with particle size (130–260 nm). Additionally, we examined the antiradical effect of levan nanoparticles and nanoemulsion in the prototype of formulations by scavenging DPPH (2,2-diphenyl-1-picrylhydrazyl; EPR spectroscopy). The model cream with both nanosystems and the whole range of products with nanosystems were evaluated in vivo for hydration, elasticity, smoothness, wrinkles and vascular lesions, discoloration, respectively. The cream improved skin condition in all tested parameters in at least 50% of volunteers. The use of more comprehensive care, additionally consisting of a tonic and gel, reduced the previously existing skin discoloration to 10.42 ± 0.58%. The presented prototype formulations are promising in improving skin conditions.
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spelling pubmed-79231902021-03-03 Targeted Hybrid Nanocarriers as a System Enhancing the Skin Structure Lewińska, Agnieszka Domżał-Kędzia, Marta Kierul, Kinga Bochynek, Michał Pannert, Dominika Nowaczyk, Piotr Łukaszewicz, Marcin Molecules Article The skin is constantly exposed to external and internal factors that disturb its function. In this work, two nanosystems-levan nanoparticles and a surfactin-stabilized nanoemulsion were preserved (tested for microbial growth) and characterized (size, polydispersity, Zeta potential, and stability). The nanosystems were introduced in the model formulations-cream, tonic, and gel, and confirmed by TEM. The analysis showed that nanoemulsion has a spherical morphology and size 220–300 nm, while levan nanoparticles had irregular shapes independently of the use of matrix and with particle size (130–260 nm). Additionally, we examined the antiradical effect of levan nanoparticles and nanoemulsion in the prototype of formulations by scavenging DPPH (2,2-diphenyl-1-picrylhydrazyl; EPR spectroscopy). The model cream with both nanosystems and the whole range of products with nanosystems were evaluated in vivo for hydration, elasticity, smoothness, wrinkles and vascular lesions, discoloration, respectively. The cream improved skin condition in all tested parameters in at least 50% of volunteers. The use of more comprehensive care, additionally consisting of a tonic and gel, reduced the previously existing skin discoloration to 10.42 ± 0.58%. The presented prototype formulations are promising in improving skin conditions. MDPI 2021-02-18 /pmc/articles/PMC7923190/ /pubmed/33670519 http://dx.doi.org/10.3390/molecules26041063 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lewińska, Agnieszka
Domżał-Kędzia, Marta
Kierul, Kinga
Bochynek, Michał
Pannert, Dominika
Nowaczyk, Piotr
Łukaszewicz, Marcin
Targeted Hybrid Nanocarriers as a System Enhancing the Skin Structure
title Targeted Hybrid Nanocarriers as a System Enhancing the Skin Structure
title_full Targeted Hybrid Nanocarriers as a System Enhancing the Skin Structure
title_fullStr Targeted Hybrid Nanocarriers as a System Enhancing the Skin Structure
title_full_unstemmed Targeted Hybrid Nanocarriers as a System Enhancing the Skin Structure
title_short Targeted Hybrid Nanocarriers as a System Enhancing the Skin Structure
title_sort targeted hybrid nanocarriers as a system enhancing the skin structure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923190/
https://www.ncbi.nlm.nih.gov/pubmed/33670519
http://dx.doi.org/10.3390/molecules26041063
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