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Initial Experience with (64)Cu-DOTATATE Digital PET of Patients with Neuroendocrine Neoplasms: Comparison with Analog PET
The recent introduction of solid-state detectors in clinical positron emission tomography (PET) scanners has significantly improved image quality and spatial resolution and shortened acquisition time compared to conventional analog PET scanners. In an initial evaluation of the performance of our new...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923227/ https://www.ncbi.nlm.nih.gov/pubmed/33669838 http://dx.doi.org/10.3390/diagnostics11020350 |
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author | Loft, Mathias Johnbeck, Camilla B. Carlsen, Esben A. Johannesen, Helle H. Oturai, Peter Langer, Seppo W. Knigge, Ulrich Kjaer, Andreas |
author_facet | Loft, Mathias Johnbeck, Camilla B. Carlsen, Esben A. Johannesen, Helle H. Oturai, Peter Langer, Seppo W. Knigge, Ulrich Kjaer, Andreas |
author_sort | Loft, Mathias |
collection | PubMed |
description | The recent introduction of solid-state detectors in clinical positron emission tomography (PET) scanners has significantly improved image quality and spatial resolution and shortened acquisition time compared to conventional analog PET scanners. In an initial evaluation of the performance of our newly acquired Siemens Biograph Vision 600 PET/CT (digital PET/CT) scanner for (64)Cu-DOTATATE imaging, we compared PET/CT acquisitions from patients with neuroendocrine neoplasms (NENs) grades 1 and 2 and stable disease on CT who were scanned on both our Siemens Biograph 128 mCT PET/CT (analog PET/CT) and digital PET/CT within 6 months as part of their routine clinical management. Five patients fulfilled the criteria and were included in the analysis. The digital PET acquisition time was less than 1/3 of the analog PET acquisition time (digital PET, mean (min:s): 08:20 (range, 07:59–09:45); analog PET, 25:28 (24:39–28:44), p < 0.001). All 44 lesions detected on the analog PET with corresponding structural correlates on the CT were also found on the digital PET performed 137 (107–176) days later. Our initial findings suggest that digital (64)Cu-DOTATATE PET can successfully be performed in patients with NENs using an image acquisition time of only 1/3 of what is used for an analog (64)Cu-DOTATATE PET. |
format | Online Article Text |
id | pubmed-7923227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79232272021-03-03 Initial Experience with (64)Cu-DOTATATE Digital PET of Patients with Neuroendocrine Neoplasms: Comparison with Analog PET Loft, Mathias Johnbeck, Camilla B. Carlsen, Esben A. Johannesen, Helle H. Oturai, Peter Langer, Seppo W. Knigge, Ulrich Kjaer, Andreas Diagnostics (Basel) Article The recent introduction of solid-state detectors in clinical positron emission tomography (PET) scanners has significantly improved image quality and spatial resolution and shortened acquisition time compared to conventional analog PET scanners. In an initial evaluation of the performance of our newly acquired Siemens Biograph Vision 600 PET/CT (digital PET/CT) scanner for (64)Cu-DOTATATE imaging, we compared PET/CT acquisitions from patients with neuroendocrine neoplasms (NENs) grades 1 and 2 and stable disease on CT who were scanned on both our Siemens Biograph 128 mCT PET/CT (analog PET/CT) and digital PET/CT within 6 months as part of their routine clinical management. Five patients fulfilled the criteria and were included in the analysis. The digital PET acquisition time was less than 1/3 of the analog PET acquisition time (digital PET, mean (min:s): 08:20 (range, 07:59–09:45); analog PET, 25:28 (24:39–28:44), p < 0.001). All 44 lesions detected on the analog PET with corresponding structural correlates on the CT were also found on the digital PET performed 137 (107–176) days later. Our initial findings suggest that digital (64)Cu-DOTATATE PET can successfully be performed in patients with NENs using an image acquisition time of only 1/3 of what is used for an analog (64)Cu-DOTATATE PET. MDPI 2021-02-19 /pmc/articles/PMC7923227/ /pubmed/33669838 http://dx.doi.org/10.3390/diagnostics11020350 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Loft, Mathias Johnbeck, Camilla B. Carlsen, Esben A. Johannesen, Helle H. Oturai, Peter Langer, Seppo W. Knigge, Ulrich Kjaer, Andreas Initial Experience with (64)Cu-DOTATATE Digital PET of Patients with Neuroendocrine Neoplasms: Comparison with Analog PET |
title | Initial Experience with (64)Cu-DOTATATE Digital PET of Patients with Neuroendocrine Neoplasms: Comparison with Analog PET |
title_full | Initial Experience with (64)Cu-DOTATATE Digital PET of Patients with Neuroendocrine Neoplasms: Comparison with Analog PET |
title_fullStr | Initial Experience with (64)Cu-DOTATATE Digital PET of Patients with Neuroendocrine Neoplasms: Comparison with Analog PET |
title_full_unstemmed | Initial Experience with (64)Cu-DOTATATE Digital PET of Patients with Neuroendocrine Neoplasms: Comparison with Analog PET |
title_short | Initial Experience with (64)Cu-DOTATATE Digital PET of Patients with Neuroendocrine Neoplasms: Comparison with Analog PET |
title_sort | initial experience with (64)cu-dotatate digital pet of patients with neuroendocrine neoplasms: comparison with analog pet |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923227/ https://www.ncbi.nlm.nih.gov/pubmed/33669838 http://dx.doi.org/10.3390/diagnostics11020350 |
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