Cargando…

Human TRIM5α: Autophagy Connects Cell-Intrinsic HIV-1 Restriction and Innate Immune Sensor Functioning

Human immunodeficiency virus-1 (HIV-1) persists as a global health concern, with an incidence rate of approximately 2 million, and estimated global prevalence of over 35 million. Combination antiretroviral treatment is highly effective, but HIV-1 patients that have been treated still suffer from chr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cloherty, Alexandra P. M., Rader, Anusca G., Compeer, Brandon, Ribeiro, Carla M. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923229/ https://www.ncbi.nlm.nih.gov/pubmed/33669846 http://dx.doi.org/10.3390/v13020320

Ejemplares similares

Autophagy-enhancing drugs limit mucosal HIV-1 acquisition and suppress viral replication ex vivo
por: Cloherty, Alexandra P. M., et al.
Publicado: (2021)

Berbamine suppresses intestinal SARS-CoV-2 infection via a BNIP3-dependent autophagy blockade
por: Cloherty, Alexandra P. M., et al.
Publicado: (2023)

Role of Human TRIM5α in Intrinsic Immunity
por: Nakayama, Emi E., et al.
Publicado: (2012)

TRIM5 is an innate immune sensor for the retrovirus capsid lattice
por: Pertel, Thomas, et al.
Publicado: (2011)

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity
por: Kimura, Tomonori, et al.
Publicado: (2015)

Proteasomal Degradation of TRIM5α during Retrovirus Restriction
por: Rold, Christopher James, et al.
Publicado: (2008)

TRIM5 Retroviral Restriction Activity Correlates with the Ability To Induce Innate Immune Signaling
por: Lascano, Josefina, et al.
Publicado: (2015)

TRIM34 restricts HIV-1 and SIV capsids in a TRIM5α-dependent manner
por: Ohainle, Molly, et al.
Publicado: (2020)

Substrate recognition by TRIM and TRIM-like proteins in innate immunity
por: Wang, Hai-Tao, et al.
Publicado: (2021)

Immunoproteasome activation enables human TRIM5α restriction of HIV-1
por: Jimenez-Guardeño, Jose M., et al.
Publicado: (2019)

Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes
por: Cerboni, Silvia, et al.
Publicado: (2017)

TRIM25 in the Regulation of the Antiviral Innate Immunity
por: Martín-Vicente, María, et al.
Publicado: (2017)

TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation
por: Chiramel, Abhilash I., et al.
Publicado: (2019)

Cyclophilin A protects HIV-1 from restriction by human TRIM5α
por: Kim, Kyusik, et al.
Publicado: (2019)

Interfering Residues Narrow the Spectrum of MLV Restriction by Human TRIM5α
por: Maillard, Pierre V, et al.
Publicado: (2007)

TRIM5α selectively binds a restriction-sensitive retroviral capsid
por: Sebastian, Sarah, et al.
Publicado: (2005)

To TRIM the Immunity: From Innate to Adaptive Immunity
por: Yang, Wenyong, et al.
Publicado: (2020)

The Roles of TRIMs in Antiviral Innate Immune Signaling
por: Shen, Zhou, et al.
Publicado: (2021)

Role of SUMO-1 and SUMO interacting motifs in rhesus TRIM5α-mediated restriction
por: Lukic, Zana, et al.
Publicado: (2013)

Evidence for Restriction of Ancient Primate Gammaretroviruses by APOBEC3 but Not TRIM5α Proteins
por: Perez-Caballero, David, et al.
Publicado: (2008)

The role of the ubiquitin-proteasome pathway in rhTRIM5α restriction of HIV-1
por: Danielson, CM, et al.
Publicado: (2010)

From Capsids to Complexes: Expanding the Role of TRIM5α in the Restriction of Divergent RNA Viruses and Elements
por: Rose, Kevin M., et al.
Publicado: (2021)

The Functions of TRIM56 in Antiviral Innate Immunity and Tumorigenesis
por: Fu, Lin, et al.
Publicado: (2023)

Visualization of a proteasome-independent intermediate during restriction of HIV-1 by rhesus TRIM5α
por: Campbell, Edward M., et al.
Publicado: (2008)

Endogenous TRIM5α Function Is Regulated by SUMOylation and Nuclear Sequestration for Efficient Innate Sensing in Dendritic Cells
por: Portilho, Débora M., et al.
Publicado: (2015)

TRIM5α restricts poxviruses and is antagonized by CypA and the viral protein C6
por: Zhao, Yiqi, et al.
Publicado: (2023)

A helical LC3-interacting region mediates the interaction between the retroviral restriction factor Trim5α and mammalian autophagy-related ATG8 proteins
por: Keown, Jeremy R., et al.
Publicado: (2018)

A non-canonical role for the autophagy machinery in anti-retroviral signaling mediated by TRIM5α
por: Saha, Bhaskar, et al.
Publicado: (2020)

TRIM proteins: New players in virus-induced autophagy
por: Sparrer, Konstantin M. J., et al.
Publicado: (2018)

Intrinsic Cellular Defenses (TRIMS) in Modulating Viral Infection and Immunity
por: García-Sastre, Adolfo, et al.
Publicado: (2016)

Primate TRIM34 is a broadly-acting, TRIM5-dependent lentiviral restriction factor
por: Twentyman, Joy, et al.
Publicado: (2023)

Primate TRIM34 is a broadly-acting, TRIM5-dependent lentiviral restriction factor
por: Twentyman, Joy, et al.
Publicado: (2023)

Inflammation gets TRIM’d back by autophagy
por: Short, Ben
Publicado: (2015)

TRIM21/Ro52 - Roles in Innate Immunity and Autoimmune Disease
por: Jones, Esther L., et al.
Publicado: (2021)

Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy
por: Saha, Bhaskar, et al.
Publicado: (2022)

A frequent SNP in TRIM5α strongly enhances the innate immune response against LINE-1 elements
por: Lagisquet, Justine, et al.
Publicado: (2023)

Impact of TRIM5α in vivo
por: Nakayama, Emi E., et al.
Publicado: (2015)

TRIM5α is a SUMO substrate
por: Dutrieux, Jacques, et al.
Publicado: (2015)

Simultaneous Neutralization and Innate Immune Detection of a Replicating Virus by TRIM21
por: Watkinson, R. E., et al.
Publicado: (2013)

Apparent effect of rabbit endogenous lentivirus type K acquisition on retrovirus restriction by lagomorph Trim5αs
por: Yap, Melvyn W., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_60ni0vlujldibtqgmndisdfj5m