Cargando…

From Combinations to Single-Molecule Polypharmacology—Cromolyn-Ibuprofen Conjugates for Alzheimer’s Disease

Despite Alzheimer’s disease (AD) incidence being projected to increase worldwide, the drugs currently on the market can only mitigate symptoms. Considering the failures of the classical paradigm “one target-one drug-one disease” in delivering effective medications for AD, polypharmacology appears to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Albertini, Claudia, Naldi, Marina, Petralla, Sabrina, Strocchi, Silvia, Grifoni, Daniela, Monti, Barbara, Bartolini, Manuela, Bolognesi, Maria Laura
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923232/ https://www.ncbi.nlm.nih.gov/pubmed/33669839 http://dx.doi.org/10.3390/molecules26041112

Ejemplares similares

α-Linolenic Acid–Valproic Acid Conjugates: Toward Single-Molecule Polypharmacology for Multiple Sclerosis
por: Rossi, Michele, et al.
Publicado: (2020)

Pharmacokinetics of Cromolyn and Ibuprofen in Healthy Elderly Volunteers
por: Brazier, David, et al.
Publicado: (2017)

Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer’s Disease
por: Gandini, Annachiara, et al.
Publicado: (2022)

Nutritional and Pharmacological Strategies to Regulate Microglial Polarization in Cognitive Aging and Alzheimer’s Disease
por: Peña-Altamira, Emiliano, et al.
Publicado: (2017)

Effects of cromolyn sodium on isolated rat's trachea
por: Lin, Yuan-Yung, et al.
Publicado: (2011)

Cromolyn Reduces Levels of the Alzheimer’s Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis
por: Zhang, Can, et al.
Publicado: (2018)

Deposition Dosages of Three Cromolyn Forms by Cascade Impactor
por: Murayama, Norihide, et al.
Publicado: (2017)

The Polypharmacological Effects of Cannabidiol
por: Castillo-Arellano, Jorge, et al.
Publicado: (2023)

Advances in Computational Polypharmacology
por: Feldmann, Christian, et al.
Publicado: (2022)

Cromolyn prevents cerebral vasospasm and dementia by targeting WDR43
por: Wang, Xingqiao, et al.
Publicado: (2023)

Polypharmacology of small molecules targeting the ubiquitin–proteasome and ubiquitin-like systems
por: Amelio, Ivano, et al.
Publicado: (2015)

Computational polypharmacology comes of age
por: Rastelli, Giulio, et al.
Publicado: (2015)

Structural and Functional View of Polypharmacology
por: Moya-García, Aurelio, et al.
Publicado: (2017)

Cromolyn Sodium for Insulin-Induced Lipoatrophy: Old Drug, New Use
por: Phua, Eng-Joo, et al.
Publicado: (2013)

Cromolyn inhibits the secretion of inflammatory cytokines by human microglia (HMC3)
por: Wang, Yi-Jun, et al.
Publicado: (2021)

Formulation and optimization of nano-sized ethosomes for enhanced transdermal delivery of cromolyn sodium
por: Rakesh, R., et al.
Publicado: (2012)

Cromolyn platform suppresses fibrosis and inflammation, promotes microglial phagocytosis and neurite outgrowth
por: Wang, Yi-Jun, et al.
Publicado: (2021)

Automated design of ligands to polypharmacological profiles
por: Besnard, Jérémy, et al.
Publicado: (2012)

Exploiting kinase polypharmacology for nerve regeneration
por: Al-Ali, Hassan, et al.
Publicado: (2016)

How polypharmacologic is each chemogenomics library?
por: Ni, Eric, et al.
Publicado: (2020)

Polypharmacology of ambroxol in the treatment of COVID-19
por: Wang, Ziyuan, et al.
Publicado: (2023)

Polypharmacology: promises and new drugs in 2022
por: Ryszkiewicz, Piotr, et al.
Publicado: (2023)

Kinome-wide polypharmacology profiling of small molecules by multi-task graph isomorphism network approach
por: Bao, Lingjie, et al.
Publicado: (2023)

Exploiting the Chalcone Scaffold to Develop Multifunctional Agents for Alzheimer’s Disease
por: Rampa, Angela, et al.
Publicado: (2018)

AlzPlatform: An Alzheimer’s Disease Domain-Specific Chemogenomics Knowledgebase for Polypharmacology and Target Identification Research
por: Liu, Haibin, et al.
Publicado: (2014)

A conjugated mTOR/MEK bifunctional inhibitor as potential polypharmacological anticancer agent: the prototype compound discovery
por: Tao, Qiangqiang, et al.
Publicado: (2020)

Polypharmacological Approaches for CNS Diseases: Focus on Endocannabinoid Degradation Inhibition
por: Papa, Alessandro, et al.
Publicado: (2022)

The Mycobacterium tuberculosis Drugome and Its Polypharmacological Implications
por: Kinnings, Sarah L., et al.
Publicado: (2010)

Curation and Analysis of Multitargeting Agents for Polypharmacological Modeling
por: Reddy, A. Srinivas, et al.
Publicado: (2014)

The kinase polypharmacology landscape of clinical PARP inhibitors
por: Antolin, Albert A., et al.
Publicado: (2020)

Cromolyn-mediated improvement of intestinal barrier function is associated with enhanced piglet performance after weaning
por: Mereu, Alessandro, et al.
Publicado: (2015)

In silico polypharmacology: retrospective recognition vs. rational design
por: Proschak, Ewgenij
Publicado: (2014)

Dual kinase-bromodomain inhibitors for rationally designed polypharmacology
por: Ciceri, Pietro, et al.
Publicado: (2014)

Epigenetic polypharmacology: from combination therapy to multitargeted drugs
por: de Lera, Angel R., et al.
Publicado: (2016)

Polypharmacology of Berberine Based on Multi-Target Binding Motifs
por: Chu, Ming, et al.
Publicado: (2018)

Privileged Structures and Polypharmacology within and between Protein Families
por: Meyers, Joshua, et al.
Publicado: (2018)

High Impact: The Role of Promiscuous Binding Sites in Polypharmacology
por: Cerisier, Natacha, et al.
Publicado: (2019)

Detecting similar binding pockets to enable systems polypharmacology
por: Duran-Frigola, Miquel, et al.
Publicado: (2017)

Polypharmacology in Precision Oncology: Current Applications and Future  Prospects
por: Antolin, Albert A., et al.
Publicado: (2016)

Discovery of talmapimod analogues as polypharmacological anti-inflammatory agents
por: Liu, Wandong, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_387artnnht1s8vseerd66dse9q