How Does Protein Nutrition Affect the Epigenetic Changes in Pig? A Review

SIMPLE SUMMARY: Epigenetic mechanisms regulate gene expression and depend of nutrition. In farm animals, and concretely, in pigs, some papers on protein nutrition have been realized to improve several productive traits. Changes in protein diet influence on epigenetic mechanisms that could affect productive and reproductive traits in individuals and their offspring. The purpose of this review was to update the current knowledge about the effects of these nutritional changes on epigenetic mechanisms in pigs. ABSTRACT: Epigenetic changes regulate gene expression and depend of external factors, such as environment and nutrition. In pigs, several studies on protein nutrition have been performed to improve productive and reproductive traits. Indeed, these studies aimed not only to determine broad protein requirements but also pigs’ essential amino acids requirements. Moreover, recent studies tried to determine these nutritional requirements for each individual, which is known as protein precision nutrition. However, nutritional changes could affect different epigenetic mechanisms, modifying metabolic pathways both in a given individual and its offspring. Modifications in protein nutrition, such as change in the amino acid profile, increase or decrease in protein levels, or the addition of metabolites that condition protein requirements, could affect the regulation of some genes, such as myostatin, insulin growth factor, or genes controlling cholesterol and glucose metabolism pathways. This review summarizes the impact of most common protein nutritional strategies on epigenetic changes and describes their effects on regulation of gene expression in pigs. In a context where animal nutrition is shifting towards precision protein nutrition (PPN), further studies evaluating the effects of PPN on animal epigenetic are necessary.