Cargando…

Use of the JAK Inhibitor Ruxolitinib in the Treatment of Hemophagocytic Lymphohistiocytosis

Hemophagocytic lymphohistiocytosis (HLH) is a rare hyperinflammatory syndrome driven by overactive T cells and macrophages that abundantly secrete numerous pro-inflammatory cytokines, including interferon (IFN)-gamma, interleukin (IL)-1-beta, IL-2, IL-6, IL-10, IL-18, and tumor necrosis factor (TNF)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Keenan, Camille, Nichols, Kim E., Albeituni, Sabrin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923355/ https://www.ncbi.nlm.nih.gov/pubmed/33664745 http://dx.doi.org/10.3389/fimmu.2021.614704

Ejemplares similares

Cellular and transcriptional impacts of Janus kinase and/or IFN-gamma inhibition in a mouse model of primary hemophagocytic lymphohistiocytosis
por: Albeituni, Sabrin, et al.
Publicado: (2023)

Dose-escalating ruxolitinib for refractory hemophagocytic lymphohistiocytosis
por: Song, Yue, et al.
Publicado: (2023)

Ruxolitinib, a JAK1/2 Inhibitor, Ameliorates Cytokine Storm in Experimental Models of Hyperinflammation Syndrome
por: Huarte, Eduardo, et al.
Publicado: (2021)

Case report: Ruxolitinib as first-line therapy for secondary hemophagocytic lymphohistiocytosis in patients with AIDS
por: Liu, Xiang, et al.
Publicado: (2022)

Case report: Optimized ruxolitinib-based therapy in an infant with familial hemophagocytic lymphohistiocytosis type 3
por: Niizato, Daiki, et al.
Publicado: (2022)

Insights into the cellular pathophysiology of familial hemophagocytic lymphohistiocytosis
por: Steen, Erica A., et al.
Publicado: (2023)

Digenic Inheritance: Evidence and Gaps in Hemophagocytic Lymphohistiocytosis
por: Steen, Erica A., et al.
Publicado: (2021)

Approaching hemophagocytic lymphohistiocytosis
por: Chinnici, Aurora, et al.
Publicado: (2023)

Ruxolitinib treatment permits lower cumulative glucocorticoid dosing in children with secondary hemophagocytic lymphohistiocytosis
por: Chi, Ying, et al.
Publicado: (2021)

Epstein–Barr Virus and Hemophagocytic Lymphohistiocytosis
por: Marsh, Rebecca A.
Publicado: (2018)

The Immunology of Macrophage Activation Syndrome
por: Crayne, Courtney B., et al.
Publicado: (2019)

How Viruses Contribute to the Pathogenesis of Hemophagocytic Lymphohistiocytosis
por: Brisse, Ellen, et al.
Publicado: (2017)

Successful resolution of hemophagocytic lymphohistiocytosis during the chemotherapy course of acute myelocytic leukemia with ruxolitinib
por: Song, Yue, et al.
Publicado: (2022)

Ruxolitinib as an Effective Treatment for Hemophagocytic Lymphohistiocytosis Secondary to SARS-Cov-2 Infection: A Case Report
por: Wang, Lina, et al.
Publicado: (2023)

Hemophagocytic Lymphohistiocytosis Following COVID-19 Infection
por: Molina, Guarina, et al.
Publicado: (2023)

Severe COVID-19-Induced Hemophagocytic Lymphohistiocytosis
por: Khan, Shahkar, et al.
Publicado: (2023)

Graded Defects in Cytotoxicity Determine Severity of Hemophagocytic Lymphohistiocytosis in Humans and Mice
por: Jessen, Birthe, et al.
Publicado: (2013)

Hemophagocytic Lymphohistiocytosis
por: Kaçar, Ayşe Gonca, et al.
Publicado: (2022)

A pilot study of ruxolitinib as a front-line therapy for 12 children with secondary hemophagocytic lymphohistiocytosis
por: Zhang, Qing, et al.
Publicado: (2020)

Ruxolitinib treatment for bronchiolitis obliterans syndrome following hematopoietic stem cell transplant in a patient with primary hemophagocytic lymphohistiocytosis
por: Meng, Guang-Qiang, et al.
Publicado: (2021)

Hemophagocytic lymphohistiocytosis in adults
por: Lee, Hyun Jeong, et al.
Publicado: (2014)

Hemophagocytic Lymphohistiocytosis Associated to Klebsiella pneumoniae Infection: A Case Report
por: Zhang, Zhiyu, et al.
Publicado: (2021)

FHLdb: A Comprehensive Database on the Molecular Basis of Familial Hemophagocytic Lymphohistiocytosis
por: Viñas-Giménez, Laura, et al.
Publicado: (2020)

A predictive model for identifying secondary underlying diseases of hemophagocytic lymphohistiocytosis
por: Gao, Wei-bo, et al.
Publicado: (2023)

Ruxolitinib as Adjunctive Therapy for Hemophagocytic LymPhohistiocytosis after Liver Transplantation: A Case Report and Literature Review
por: He, Kang, et al.
Publicado: (2022)

The Treatment Based on Ruxolitinib and Amphotericin B is Effective for Relapsed Leishmaniasis-Related Hemophagocytic Lymphohistiocytosis: A Case Report and Literature Review
por: Cui, Tingting, et al.
Publicado: (2022)

Simple Evaluation of Clinical Situation and Subtypes of Pediatric Hemophagocytic Lymphohistiocytosis by Cytokine Patterns
por: Xu, Xiao-Jun, et al.
Publicado: (2022)

A prediction model for acute kidney injury in adult patients with hemophagocytic lymphohistiocytosis
por: Wang, Siwen, et al.
Publicado: (2022)

Hemophagocytic lymphohistiocytosis in adults
por: Machaczka, Maciej
Publicado: (2013)

Hemophagocytic Lymphohistiocytosis in Dermatomyositis
por: Liao, Hsien-Tzung, et al.
Publicado: (2019)

Hemophagocytic Lymphohistiocytosis Syndromes
por: Standage, Stephen W., et al.
Publicado: (2014)

Hemophagocytic Lymphohistiocytosis in Children: Pathogenesis and Treatment
por: Ishii, Eiichi
Publicado: (2016)

The Spectrum of Clinical, Immunological, and Molecular Findings in Familial Hemophagocytic Lymphohistiocytosis: Experience From India
por: Shabrish, Snehal, et al.
Publicado: (2021)

Elevated Granzyme B in Cytotoxic Lymphocytes is a Signature of Immune Activation in Hemophagocytic Lymphohistiocytosis
por: Mellor-Heineke, Sabine, et al.
Publicado: (2013)

Familial Hemophagocytic Lymphohistiocytosis: When Rare Diseases Shed Light on Immune System Functioning
por: Sieni, Elena, et al.
Publicado: (2014)

Pathogenic Gene Mutations or Variants Identified by Targeted Gene Sequencing in Adults With Hemophagocytic Lymphohistiocytosis
por: Miao, Yi, et al.
Publicado: (2019)

Cell Versus Cytokine – Directed Therapies for Hemophagocytic Lymphohistiocytosis (HLH) in Inborn Errors of Immunity
por: Wegehaupt, Oliver, et al.
Publicado: (2020)

The Outcome of Induction Therapy for EBV-Related Hemophagocytic Lymphohistiocytosis: A Model for Risk Stratification
por: Cui, Tingting, et al.
Publicado: (2022)

Case report: Hemophagocytic lymphohistiocytosis in a child with primary immunodeficiency infected with Talaromyces marneffei
por: Yan, Huimin, et al.
Publicado: (2022)

Imaging characteristics of hemophagocytic lymphohistiocytosis
por: Fitzgerald, Nancy E., et al.
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_5ksko8or8fk5pg0nbp62vea70l