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HIV-1 Vpr activates host CRL4-DCAF1 E3 ligase to degrade histone deacetylase SIRT7

BACKGROUND: Vpr is a virion-associated protein that is encoded by lentiviruses and serves to counteract intrinsic immunity factors that restrict infection. HIV-1 Vpr mediates proteasome-dependent degradation of several DNA repair/modification proteins. Mechanistically, Vpr directly recruits cellular...

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Detalles Bibliográficos
Autores principales:	Zhou, Xiaohong, Monnie, Christina, DeLucia, Maria, Ahn, Jinwoo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923639/ https://www.ncbi.nlm.nih.gov/pubmed/33648539 http://dx.doi.org/10.1186/s12985-021-01514-2

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