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Identification of a potent antagonist of smoothened in hedgehog signaling

BACKGROUND: Hedgehog signaling is essential to the regulation of embryonic development, tissue homeostasis, and stem cell self-renewal, making it a prime target for developing cancer therapeutics. Given the close link between aberrant Hedgehog signaling and cancers, many small molecular compounds ha...

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Detalles Bibliográficos
Autores principales:	Fan, Junwan, Li, Haowen, Kuang, Lun, Zhao, Zichen, He, Wenyan, Liu, Chen, Wang, Yongjun, Cheng, Steven Y., Chen, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923671/ https://www.ncbi.nlm.nih.gov/pubmed/33653381 http://dx.doi.org/10.1186/s13578-021-00558-9

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