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Rheological and Microstructural Evaluation of Collagen-Based Scaffolds Crosslinked with Fructose
In recent years, tissue engineering research has led to the development of this field by designing scaffolds with better properties that can fulfill its purpose of better and faster tissue regeneration, consequently improving people’s quality of life. Scaffolds are matrices, predominantly composed o...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923766/ https://www.ncbi.nlm.nih.gov/pubmed/33672532 http://dx.doi.org/10.3390/polym13040632 |
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author | Sánchez-Cid, Pablo Jiménez‑Rosado, Mercedes Perez-Puyana, Victor Guerrero, Antonio Romero, Alberto |
author_facet | Sánchez-Cid, Pablo Jiménez‑Rosado, Mercedes Perez-Puyana, Victor Guerrero, Antonio Romero, Alberto |
author_sort | Sánchez-Cid, Pablo |
collection | PubMed |
description | In recent years, tissue engineering research has led to the development of this field by designing scaffolds with better properties that can fulfill its purpose of better and faster tissue regeneration, consequently improving people’s quality of life. Scaffolds are matrices, predominantly composed of polymeric materials, whose main function is to offer support for cell adhesion and subsequent growth, leading to the regeneration of the damaged tissue. The widely used biopolymer in tissue engineering is collagen, which is the most abundant protein in animals. Its use is due to its structure, biocompatibility, ease of modification, and processability. In this work, collagen-based scaffolds were developed with different concentrations and processing techniques, by obtaining hydrogels and aerogels that were characterized with an emphasis on their morphology and mechanical properties. Moreover, fructose was added in some cases as a chemical crosslinking agent to study its influence on the scaffolds’ properties. The obtained results revealed that the scaffolds with higher collagen concentrations were more rigid and deformable. Comparing both systems, the aerogels were more rigid, although the hydrogels were more deformable and had higher pore size homogeneity. Fructose addition produced a slight increase in the critical strain, together with an increase in the elastic modulus. |
format | Online Article Text |
id | pubmed-7923766 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79237662021-03-03 Rheological and Microstructural Evaluation of Collagen-Based Scaffolds Crosslinked with Fructose Sánchez-Cid, Pablo Jiménez‑Rosado, Mercedes Perez-Puyana, Victor Guerrero, Antonio Romero, Alberto Polymers (Basel) Article In recent years, tissue engineering research has led to the development of this field by designing scaffolds with better properties that can fulfill its purpose of better and faster tissue regeneration, consequently improving people’s quality of life. Scaffolds are matrices, predominantly composed of polymeric materials, whose main function is to offer support for cell adhesion and subsequent growth, leading to the regeneration of the damaged tissue. The widely used biopolymer in tissue engineering is collagen, which is the most abundant protein in animals. Its use is due to its structure, biocompatibility, ease of modification, and processability. In this work, collagen-based scaffolds were developed with different concentrations and processing techniques, by obtaining hydrogels and aerogels that were characterized with an emphasis on their morphology and mechanical properties. Moreover, fructose was added in some cases as a chemical crosslinking agent to study its influence on the scaffolds’ properties. The obtained results revealed that the scaffolds with higher collagen concentrations were more rigid and deformable. Comparing both systems, the aerogels were more rigid, although the hydrogels were more deformable and had higher pore size homogeneity. Fructose addition produced a slight increase in the critical strain, together with an increase in the elastic modulus. MDPI 2021-02-20 /pmc/articles/PMC7923766/ /pubmed/33672532 http://dx.doi.org/10.3390/polym13040632 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sánchez-Cid, Pablo Jiménez‑Rosado, Mercedes Perez-Puyana, Victor Guerrero, Antonio Romero, Alberto Rheological and Microstructural Evaluation of Collagen-Based Scaffolds Crosslinked with Fructose |
title | Rheological and Microstructural Evaluation of Collagen-Based Scaffolds Crosslinked with Fructose |
title_full | Rheological and Microstructural Evaluation of Collagen-Based Scaffolds Crosslinked with Fructose |
title_fullStr | Rheological and Microstructural Evaluation of Collagen-Based Scaffolds Crosslinked with Fructose |
title_full_unstemmed | Rheological and Microstructural Evaluation of Collagen-Based Scaffolds Crosslinked with Fructose |
title_short | Rheological and Microstructural Evaluation of Collagen-Based Scaffolds Crosslinked with Fructose |
title_sort | rheological and microstructural evaluation of collagen-based scaffolds crosslinked with fructose |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923766/ https://www.ncbi.nlm.nih.gov/pubmed/33672532 http://dx.doi.org/10.3390/polym13040632 |
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