Cargando…
Analysis of absolute lymphocyte count in patients with COVID-19
INTRODUCTION: Symptoms of COVID-19 vary in severity and presentation. When admitting patients to the hospital, it is desirable to isolate patients with COVID-19 from those without the disease. However, reliably identifying patients with COVID-19 in the emergency department before hospital admission...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923864/ https://www.ncbi.nlm.nih.gov/pubmed/33706251 http://dx.doi.org/10.1016/j.ajem.2021.02.054 |
_version_ | 1783658981530533888 |
---|---|
author | Illg, Zachary Muller, Gregory Mueller, Matthew Nippert, Justin Allen, Brian |
author_facet | Illg, Zachary Muller, Gregory Mueller, Matthew Nippert, Justin Allen, Brian |
author_sort | Illg, Zachary |
collection | PubMed |
description | INTRODUCTION: Symptoms of COVID-19 vary in severity and presentation. When admitting patients to the hospital, it is desirable to isolate patients with COVID-19 from those without the disease. However, reliably identifying patients with COVID-19 in the emergency department before hospital admission is often limited by the speed and availability of testing. Previous studies determined a low lymphocyte count is commonly found in patients with COVID-19. We sought to explore the sensitivity of absolute lymphocyte count in patients presenting to the emergency department requiring subsequent hospitalization who were found to have COVID-19. METHODS: A retrospective chart review was performed on 312 patients with laboratory-confirmed COVID-19 who were admitted to the hospital from the emergency department. The absolute lymphocyte count for these patients was used to calculate sensitivities at various cut-off values. The relationships between absolute lymphocyte count and variables, including age, sex, need for intubation, and mortality, were also explored. RESULTS: Cut-off values for absolute lymphocyte count ranged from 1.1 K/uL to 2.0 K/uL, with sensitivities of 72% and 94%, respectively. Additionally, lower mean absolute lymphocyte counts were identified in males, patients who required intubation, and patients who died. CONCLUSION: Knowing the sensitivity of absolute lymphocyte count in patients with COVID-19 may help identify patients who are unlikely to have the disease. Additionally, absolute lymphocyte count can be used as a marker of disease severity in patients with COVID-19. |
format | Online Article Text |
id | pubmed-7923864 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79238642021-03-03 Analysis of absolute lymphocyte count in patients with COVID-19 Illg, Zachary Muller, Gregory Mueller, Matthew Nippert, Justin Allen, Brian Am J Emerg Med Article INTRODUCTION: Symptoms of COVID-19 vary in severity and presentation. When admitting patients to the hospital, it is desirable to isolate patients with COVID-19 from those without the disease. However, reliably identifying patients with COVID-19 in the emergency department before hospital admission is often limited by the speed and availability of testing. Previous studies determined a low lymphocyte count is commonly found in patients with COVID-19. We sought to explore the sensitivity of absolute lymphocyte count in patients presenting to the emergency department requiring subsequent hospitalization who were found to have COVID-19. METHODS: A retrospective chart review was performed on 312 patients with laboratory-confirmed COVID-19 who were admitted to the hospital from the emergency department. The absolute lymphocyte count for these patients was used to calculate sensitivities at various cut-off values. The relationships between absolute lymphocyte count and variables, including age, sex, need for intubation, and mortality, were also explored. RESULTS: Cut-off values for absolute lymphocyte count ranged from 1.1 K/uL to 2.0 K/uL, with sensitivities of 72% and 94%, respectively. Additionally, lower mean absolute lymphocyte counts were identified in males, patients who required intubation, and patients who died. CONCLUSION: Knowing the sensitivity of absolute lymphocyte count in patients with COVID-19 may help identify patients who are unlikely to have the disease. Additionally, absolute lymphocyte count can be used as a marker of disease severity in patients with COVID-19. Elsevier Inc. 2021-08 2021-03-02 /pmc/articles/PMC7923864/ /pubmed/33706251 http://dx.doi.org/10.1016/j.ajem.2021.02.054 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Illg, Zachary Muller, Gregory Mueller, Matthew Nippert, Justin Allen, Brian Analysis of absolute lymphocyte count in patients with COVID-19 |
title | Analysis of absolute lymphocyte count in patients with COVID-19 |
title_full | Analysis of absolute lymphocyte count in patients with COVID-19 |
title_fullStr | Analysis of absolute lymphocyte count in patients with COVID-19 |
title_full_unstemmed | Analysis of absolute lymphocyte count in patients with COVID-19 |
title_short | Analysis of absolute lymphocyte count in patients with COVID-19 |
title_sort | analysis of absolute lymphocyte count in patients with covid-19 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923864/ https://www.ncbi.nlm.nih.gov/pubmed/33706251 http://dx.doi.org/10.1016/j.ajem.2021.02.054 |
work_keys_str_mv | AT illgzachary analysisofabsolutelymphocytecountinpatientswithcovid19 AT mullergregory analysisofabsolutelymphocytecountinpatientswithcovid19 AT muellermatthew analysisofabsolutelymphocytecountinpatientswithcovid19 AT nippertjustin analysisofabsolutelymphocytecountinpatientswithcovid19 AT allenbrian analysisofabsolutelymphocytecountinpatientswithcovid19 |