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Correlation of the rise and fall in COVID-19 cases with the social isolation index and early outpatient treatment with hydroxychloroquine and chloroquine in the state of Santa Catarina, southern Brazil: A retrospective analysis

BACKGROUND: To contribute to the understanding of the coronavirus disease (COVID-19) pandemic, this study evaluated the correlations of the frequencies of COVID-19 cases, hospitalisations due to COVID-19, and deaths due to COVID-19 with social isolation indices and outpatient prescriptions of hydrox...

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Autor principal: Neves, Fabricio Souza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923871/
https://www.ncbi.nlm.nih.gov/pubmed/33667717
http://dx.doi.org/10.1016/j.tmaid.2021.102005
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author Neves, Fabricio Souza
author_facet Neves, Fabricio Souza
author_sort Neves, Fabricio Souza
collection PubMed
description BACKGROUND: To contribute to the understanding of the coronavirus disease (COVID-19) pandemic, this study evaluated the correlations of the frequencies of COVID-19 cases, hospitalisations due to COVID-19, and deaths due to COVID-19 with social isolation indices and outpatient prescriptions of hydroxychloroquine and chloroquine in the state of Santa Catarina, southern Brazil. METHODS: This was an analytical, observational, retrospective study based on secondary data that were obtained from public Brazilian databases and covered the period from March 1, 2020 to October 31, 2020 (epidemiological weeks 10–44). Data on weekly COVID-19 cases, hospitalisations and deaths due COVID-19, sales of chloroquine and hydroxychloroquine, and social isolation indices were obtained. Associations between the variables were tested using multiple linear regression analysis. RESULTS: In all regions of Santa Catarina, there were almost simultaneous peaks of COVID-19 pandemic in weeks 28–31, followed by a sudden decrease. Social isolation indices were not associated with the outcomes; sales of chloroquine and hydroxychloroquine were significant predictors of all outcomes (p < 0.001). COVID-19 prevalence was significantly different across the state regions when COVID-19 cases started to decline (p < 0.001). DISCUSSION: Collective immunity and social isolation may not have been the only causes for the reduction of the COVID-19 pandemic observed in Santa Catarina. The results of this study were compatible with the hypothesis that early treatment of COVID-19 cases with chloroquine or hydroxychloroquine may contribute to reducing the transmissibility of COVID-19 in the population. This hypothesis needs to be further tested in future studies.
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spelling pubmed-79238712021-03-03 Correlation of the rise and fall in COVID-19 cases with the social isolation index and early outpatient treatment with hydroxychloroquine and chloroquine in the state of Santa Catarina, southern Brazil: A retrospective analysis Neves, Fabricio Souza Travel Med Infect Dis Original Article BACKGROUND: To contribute to the understanding of the coronavirus disease (COVID-19) pandemic, this study evaluated the correlations of the frequencies of COVID-19 cases, hospitalisations due to COVID-19, and deaths due to COVID-19 with social isolation indices and outpatient prescriptions of hydroxychloroquine and chloroquine in the state of Santa Catarina, southern Brazil. METHODS: This was an analytical, observational, retrospective study based on secondary data that were obtained from public Brazilian databases and covered the period from March 1, 2020 to October 31, 2020 (epidemiological weeks 10–44). Data on weekly COVID-19 cases, hospitalisations and deaths due COVID-19, sales of chloroquine and hydroxychloroquine, and social isolation indices were obtained. Associations between the variables were tested using multiple linear regression analysis. RESULTS: In all regions of Santa Catarina, there were almost simultaneous peaks of COVID-19 pandemic in weeks 28–31, followed by a sudden decrease. Social isolation indices were not associated with the outcomes; sales of chloroquine and hydroxychloroquine were significant predictors of all outcomes (p < 0.001). COVID-19 prevalence was significantly different across the state regions when COVID-19 cases started to decline (p < 0.001). DISCUSSION: Collective immunity and social isolation may not have been the only causes for the reduction of the COVID-19 pandemic observed in Santa Catarina. The results of this study were compatible with the hypothesis that early treatment of COVID-19 cases with chloroquine or hydroxychloroquine may contribute to reducing the transmissibility of COVID-19 in the population. This hypothesis needs to be further tested in future studies. Elsevier Ltd. 2021 2021-03-02 /pmc/articles/PMC7923871/ /pubmed/33667717 http://dx.doi.org/10.1016/j.tmaid.2021.102005 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Neves, Fabricio Souza
Correlation of the rise and fall in COVID-19 cases with the social isolation index and early outpatient treatment with hydroxychloroquine and chloroquine in the state of Santa Catarina, southern Brazil: A retrospective analysis
title Correlation of the rise and fall in COVID-19 cases with the social isolation index and early outpatient treatment with hydroxychloroquine and chloroquine in the state of Santa Catarina, southern Brazil: A retrospective analysis
title_full Correlation of the rise and fall in COVID-19 cases with the social isolation index and early outpatient treatment with hydroxychloroquine and chloroquine in the state of Santa Catarina, southern Brazil: A retrospective analysis
title_fullStr Correlation of the rise and fall in COVID-19 cases with the social isolation index and early outpatient treatment with hydroxychloroquine and chloroquine in the state of Santa Catarina, southern Brazil: A retrospective analysis
title_full_unstemmed Correlation of the rise and fall in COVID-19 cases with the social isolation index and early outpatient treatment with hydroxychloroquine and chloroquine in the state of Santa Catarina, southern Brazil: A retrospective analysis
title_short Correlation of the rise and fall in COVID-19 cases with the social isolation index and early outpatient treatment with hydroxychloroquine and chloroquine in the state of Santa Catarina, southern Brazil: A retrospective analysis
title_sort correlation of the rise and fall in covid-19 cases with the social isolation index and early outpatient treatment with hydroxychloroquine and chloroquine in the state of santa catarina, southern brazil: a retrospective analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923871/
https://www.ncbi.nlm.nih.gov/pubmed/33667717
http://dx.doi.org/10.1016/j.tmaid.2021.102005
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