Transcranial Direct Current Stimulation Combined with Botulinum Neurotoxin Type A Injections for Treatment of Upper Limb Intention Tremor in Multiple Sclerosis: A Case Report

Upper limb intention tremor is a common cause of disability in multiple sclerosis (MS). Transcranial direct current stimulation (tDCS) is an emerging form of brain stimulation used to improve sensorimotor impairments in many neurological disorders. Here, we describe a combined therapeutic approach w...

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Autores principales: Facciorusso, Salvatore, Spina, Stefania, Santoro, Luigi, Cinone, Nicoletta, Baricich, Alessio, Ciritella, Chiara, Fiore, Pietro, Santamato, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Single Case − General Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923919/
https://www.ncbi.nlm.nih.gov/pubmed/33708100
http://dx.doi.org/10.1159/000512324
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author Facciorusso, Salvatore
Spina, Stefania
Santoro, Luigi
Cinone, Nicoletta
Baricich, Alessio
Ciritella, Chiara
Fiore, Pietro
Santamato, Andrea
author_facet Facciorusso, Salvatore
Spina, Stefania
Santoro, Luigi
Cinone, Nicoletta
Baricich, Alessio
Ciritella, Chiara
Fiore, Pietro
Santamato, Andrea
author_sort Facciorusso, Salvatore
collection PubMed
description Upper limb intention tremor is a common cause of disability in multiple sclerosis (MS). Transcranial direct current stimulation (tDCS) is an emerging form of brain stimulation used to improve sensorimotor impairments in many neurological disorders. Here, we describe a combined therapeutic approach with botulinum neurotoxin type A (BoNT-A) and tDCS for the treatment of upper limb tremor in a patient with MS. We administered a cathodal tDCS 15 days after the injections of BoNT-A. Both post-injection and post-stimulation evaluation revealed a considerable improvement of the tremor. This approach positively affected the patient's activities of daily living. Our case report shows a safe and beneficial effect of tDCS in the treatment of action tremor in MS especially as a possible adjunctive synergic treatment with BoNT-A injections.
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spelling pubmed-79239192021-03-10 Transcranial Direct Current Stimulation Combined with Botulinum Neurotoxin Type A Injections for Treatment of Upper Limb Intention Tremor in Multiple Sclerosis: A Case Report Facciorusso, Salvatore Spina, Stefania Santoro, Luigi Cinone, Nicoletta Baricich, Alessio Ciritella, Chiara Fiore, Pietro Santamato, Andrea Case Rep Neurol Single Case − General Neurology Upper limb intention tremor is a common cause of disability in multiple sclerosis (MS). Transcranial direct current stimulation (tDCS) is an emerging form of brain stimulation used to improve sensorimotor impairments in many neurological disorders. Here, we describe a combined therapeutic approach with botulinum neurotoxin type A (BoNT-A) and tDCS for the treatment of upper limb tremor in a patient with MS. We administered a cathodal tDCS 15 days after the injections of BoNT-A. Both post-injection and post-stimulation evaluation revealed a considerable improvement of the tremor. This approach positively affected the patient's activities of daily living. Our case report shows a safe and beneficial effect of tDCS in the treatment of action tremor in MS especially as a possible adjunctive synergic treatment with BoNT-A injections. S. Karger AG 2021-02-15 /pmc/articles/PMC7923919/ /pubmed/33708100 http://dx.doi.org/10.1159/000512324 Text en Copyright © 2021 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case − General Neurology
Facciorusso, Salvatore
Spina, Stefania
Santoro, Luigi
Cinone, Nicoletta
Baricich, Alessio
Ciritella, Chiara
Fiore, Pietro
Santamato, Andrea
Transcranial Direct Current Stimulation Combined with Botulinum Neurotoxin Type A Injections for Treatment of Upper Limb Intention Tremor in Multiple Sclerosis: A Case Report
title Transcranial Direct Current Stimulation Combined with Botulinum Neurotoxin Type A Injections for Treatment of Upper Limb Intention Tremor in Multiple Sclerosis: A Case Report
title_full Transcranial Direct Current Stimulation Combined with Botulinum Neurotoxin Type A Injections for Treatment of Upper Limb Intention Tremor in Multiple Sclerosis: A Case Report
title_fullStr Transcranial Direct Current Stimulation Combined with Botulinum Neurotoxin Type A Injections for Treatment of Upper Limb Intention Tremor in Multiple Sclerosis: A Case Report
title_full_unstemmed Transcranial Direct Current Stimulation Combined with Botulinum Neurotoxin Type A Injections for Treatment of Upper Limb Intention Tremor in Multiple Sclerosis: A Case Report
title_short Transcranial Direct Current Stimulation Combined with Botulinum Neurotoxin Type A Injections for Treatment of Upper Limb Intention Tremor in Multiple Sclerosis: A Case Report
title_sort transcranial direct current stimulation combined with botulinum neurotoxin type a injections for treatment of upper limb intention tremor in multiple sclerosis: a case report
topic Single Case − General Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923919/
https://www.ncbi.nlm.nih.gov/pubmed/33708100
http://dx.doi.org/10.1159/000512324
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