CDK11 Promotes Cytokine-Induced Apoptosis in Pancreatic Beta Cells Independently of Glucose Concentration and Is Regulated by Inflammation in the NOD Mouse Model

BACKGROUND: Pancreatic islets are exposed to strong pro-apoptotic stimuli: inflammation and hyperglycemia, during the progression of the autoimmune diabetes (T1D). We found that the Cdk11(Cyclin Dependent Kinase 11) is downregulated by inflammation in the T1D prone NOD (non-obese diabetic) mouse mod...

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Detalles Bibliográficos
Autores principales: Sala, Ester, Vived, Celia, Luna, Júlia, Saavedra-Ávila, Noemí Alejandra, Sengupta, Upasana, Castaño, A. Raúl, Villar-Pazos, Sabrina, Haba, Laura, Verdaguer, Joan, Ropero, Ana B., Stratmann, Thomas, Pizarro, Javier, Vázquez-Carrera, Manuel, Nadal, Angel, Lahti, Jill M., Mora, Conchi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923961/
https://www.ncbi.nlm.nih.gov/pubmed/33664748
http://dx.doi.org/10.3389/fimmu.2021.634797

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