Cargando…

Associations of Circulating Irisin with FNDC5 Expression in Fat and Muscle in Type 1 and Type 2 Diabetic Mice

Irisin is an exercise-induced myokine, suggested to exert beneficial effects on metabolism. However, the studies on the regulation of irisin secretion and the expression of its precursor FNDC5 have shown conflicting data. The discrepancies among previous correlation studies in humans are related to...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Songling, Piao, Lingjuan, Ma, Eun Bi, Ha, Hunjoo, Huh, Joo Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924053/
https://www.ncbi.nlm.nih.gov/pubmed/33672565
http://dx.doi.org/10.3390/biom11020322
_version_ 1783659010351693824
author Jiang, Songling
Piao, Lingjuan
Ma, Eun Bi
Ha, Hunjoo
Huh, Joo Young
author_facet Jiang, Songling
Piao, Lingjuan
Ma, Eun Bi
Ha, Hunjoo
Huh, Joo Young
author_sort Jiang, Songling
collection PubMed
description Irisin is an exercise-induced myokine, suggested to exert beneficial effects on metabolism. However, the studies on the regulation of irisin secretion and the expression of its precursor FNDC5 have shown conflicting data. The discrepancies among previous correlation studies in humans are related to the heterogeneity of the study population. The fact that irisin is not only a myokine but also an adipokine leads to the further complexity of the role of irisin in metabolic regulation. In this study, we examined the regulation of FNDC5 expression and irisin in circulation in both type 1 and type 2 diabetic mice, and their potential relationships with metabolic parameters. In streptozotocin (STZ)-induced type 1 diabetic mice, high-fat diet (HFD)-induced obese mice and db/db mice, the circulating irisin as well as FNDC5 gene expression in subcutaneous fat was downregulated. Muscle FNDC5 expression was only significantly lower in STZ mice, and epididymal fat FNDC5 expression was unaltered. It is interesting to note that plasma irisin levels correlated positively with subcutaneous fat FNDC5 expression, but not epididymal fat or muscle. Moreover, both irisin levels and subcutaneous fat FNDC5 correlated negatively with markers of insulin resistance. These results suggest a regulatory role for subcutaneous fat-derived FNDC5/irisin in metabolic disease.
format Online
Article
Text
id pubmed-7924053
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-79240532021-03-03 Associations of Circulating Irisin with FNDC5 Expression in Fat and Muscle in Type 1 and Type 2 Diabetic Mice Jiang, Songling Piao, Lingjuan Ma, Eun Bi Ha, Hunjoo Huh, Joo Young Biomolecules Article Irisin is an exercise-induced myokine, suggested to exert beneficial effects on metabolism. However, the studies on the regulation of irisin secretion and the expression of its precursor FNDC5 have shown conflicting data. The discrepancies among previous correlation studies in humans are related to the heterogeneity of the study population. The fact that irisin is not only a myokine but also an adipokine leads to the further complexity of the role of irisin in metabolic regulation. In this study, we examined the regulation of FNDC5 expression and irisin in circulation in both type 1 and type 2 diabetic mice, and their potential relationships with metabolic parameters. In streptozotocin (STZ)-induced type 1 diabetic mice, high-fat diet (HFD)-induced obese mice and db/db mice, the circulating irisin as well as FNDC5 gene expression in subcutaneous fat was downregulated. Muscle FNDC5 expression was only significantly lower in STZ mice, and epididymal fat FNDC5 expression was unaltered. It is interesting to note that plasma irisin levels correlated positively with subcutaneous fat FNDC5 expression, but not epididymal fat or muscle. Moreover, both irisin levels and subcutaneous fat FNDC5 correlated negatively with markers of insulin resistance. These results suggest a regulatory role for subcutaneous fat-derived FNDC5/irisin in metabolic disease. MDPI 2021-02-20 /pmc/articles/PMC7924053/ /pubmed/33672565 http://dx.doi.org/10.3390/biom11020322 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jiang, Songling
Piao, Lingjuan
Ma, Eun Bi
Ha, Hunjoo
Huh, Joo Young
Associations of Circulating Irisin with FNDC5 Expression in Fat and Muscle in Type 1 and Type 2 Diabetic Mice
title Associations of Circulating Irisin with FNDC5 Expression in Fat and Muscle in Type 1 and Type 2 Diabetic Mice
title_full Associations of Circulating Irisin with FNDC5 Expression in Fat and Muscle in Type 1 and Type 2 Diabetic Mice
title_fullStr Associations of Circulating Irisin with FNDC5 Expression in Fat and Muscle in Type 1 and Type 2 Diabetic Mice
title_full_unstemmed Associations of Circulating Irisin with FNDC5 Expression in Fat and Muscle in Type 1 and Type 2 Diabetic Mice
title_short Associations of Circulating Irisin with FNDC5 Expression in Fat and Muscle in Type 1 and Type 2 Diabetic Mice
title_sort associations of circulating irisin with fndc5 expression in fat and muscle in type 1 and type 2 diabetic mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924053/
https://www.ncbi.nlm.nih.gov/pubmed/33672565
http://dx.doi.org/10.3390/biom11020322
work_keys_str_mv AT jiangsongling associationsofcirculatingirisinwithfndc5expressioninfatandmuscleintype1andtype2diabeticmice
AT piaolingjuan associationsofcirculatingirisinwithfndc5expressioninfatandmuscleintype1andtype2diabeticmice
AT maeunbi associationsofcirculatingirisinwithfndc5expressioninfatandmuscleintype1andtype2diabeticmice
AT hahunjoo associationsofcirculatingirisinwithfndc5expressioninfatandmuscleintype1andtype2diabeticmice
AT huhjooyoung associationsofcirculatingirisinwithfndc5expressioninfatandmuscleintype1andtype2diabeticmice