An Update on the Molecular Pathology of Metaplastic Breast Cancer

Metaplastic breast cancer (MpBC) is a fascinating morphologic sub-type of breast cancer, characterised by intra-tumoural heterogeneity. By definition, these tumors show regions of metaplasia that can present as spindle, squamous, chondroid or even osseous differentiation. MpBC are typically triple-n...

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Detalles Bibliográficos
Autores principales: McCart Reed, Amy E, Kalaw, Emarene M, Lakhani, Sunil R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924111/
https://www.ncbi.nlm.nih.gov/pubmed/33664587
http://dx.doi.org/10.2147/BCTT.S296784
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author McCart Reed, Amy E
Kalaw, Emarene M
Lakhani, Sunil R
author_facet McCart Reed, Amy E
Kalaw, Emarene M
Lakhani, Sunil R
author_sort McCart Reed, Amy E
collection PubMed
description Metaplastic breast cancer (MpBC) is a fascinating morphologic sub-type of breast cancer, characterised by intra-tumoural heterogeneity. By definition, these tumors show regions of metaplasia that can present as spindle, squamous, chondroid or even osseous differentiation. MpBC are typically triple-negative, and are therefore not targetable with hormone therapy or anti-HER2 therapies, leaving only chemotherapeutics for management. MpBC are known for their aggressive course and poor response to chemotherapy. We review herein the pathology and molecular landscape of MpBC and discuss opportunities for targetted therapies as well as immunotherapies.
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spelling pubmed-79241112021-03-03 An Update on the Molecular Pathology of Metaplastic Breast Cancer McCart Reed, Amy E Kalaw, Emarene M Lakhani, Sunil R Breast Cancer (Dove Med Press) Review Metaplastic breast cancer (MpBC) is a fascinating morphologic sub-type of breast cancer, characterised by intra-tumoural heterogeneity. By definition, these tumors show regions of metaplasia that can present as spindle, squamous, chondroid or even osseous differentiation. MpBC are typically triple-negative, and are therefore not targetable with hormone therapy or anti-HER2 therapies, leaving only chemotherapeutics for management. MpBC are known for their aggressive course and poor response to chemotherapy. We review herein the pathology and molecular landscape of MpBC and discuss opportunities for targetted therapies as well as immunotherapies. Dove 2021-02-26 /pmc/articles/PMC7924111/ /pubmed/33664587 http://dx.doi.org/10.2147/BCTT.S296784 Text en © 2021 McCart Reed et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
McCart Reed, Amy E
Kalaw, Emarene M
Lakhani, Sunil R
An Update on the Molecular Pathology of Metaplastic Breast Cancer
title An Update on the Molecular Pathology of Metaplastic Breast Cancer
title_full An Update on the Molecular Pathology of Metaplastic Breast Cancer
title_fullStr An Update on the Molecular Pathology of Metaplastic Breast Cancer
title_full_unstemmed An Update on the Molecular Pathology of Metaplastic Breast Cancer
title_short An Update on the Molecular Pathology of Metaplastic Breast Cancer
title_sort update on the molecular pathology of metaplastic breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924111/
https://www.ncbi.nlm.nih.gov/pubmed/33664587
http://dx.doi.org/10.2147/BCTT.S296784
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