A catalog of associations between rare coding variants and COVID-19 outcomes

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease-19 (COVID-19), a respiratory illness that can result in hospitalization or death. We investigated associations between rare genetic variants and seven COVID-19 outcomes in 543,213 individuals, including 8,248 wit...

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Detalles Bibliográficos
Autores principales: Kosmicki, J. A., Horowitz, J. E., Banerjee, N., Lanche, R., Marcketta, A., Maxwell, E., Bai, X., Sun, D., Backman, J. D., Sharma, D., Kang, H. M., O’Dushlaine, C., Yadav, A., Mansfield, A. J., Li, A. H., Watanabe, K., Gurski, L., McCarthy, S. E., Locke, A. E., Khalid, S., O’Keeffe, S., Mbatchou, J., Chazara, O., Huang, Y., Kvikstad, E., O’Neill, A., Nioi, P., Parker, M. M., Petrovski, S., Runz, H., Szustakowski, J. D., Wang, Q., Wong, E., Cordova-Palomera, A., Smith, E. N., Szalma, S., Zheng, X., Esmaeeli, S., Davis, J. W., Lai, Y-P., Chen, X., Justice, A. E., Leader, J. B., Mirshahi, T., Carey, D. J., Verma, A., Sirugo, G., Ritchie, M. D., Rader, D. J., Povysil, G., Goldstein, D. B., Kiryluk, K., Pairo-Castineira, E., Rawlik, K., Pasko, D., Walker, S., Meynert, A., Kousathanas, A., Moutsianas, L., Tenesa, A., Caulfield, M., Scott, R., Wilson, J. F., Baillie, J. K., Butler-Laporte, G., Nakanishi, T., Lathrop, M., Richards, J.B., Jones, M., Balasubramanian, S., Salerno, W., Shuldiner, A. R., Marchini, J., Overton, J. D., Habegger, L., Cantor, M. N., Reid, J. G., Baras, A., Abecasis, G. R., Ferreira, M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924298/
https://www.ncbi.nlm.nih.gov/pubmed/33655273
http://dx.doi.org/10.1101/2020.10.28.20221804
Descripción
Sumario:Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease-19 (COVID-19), a respiratory illness that can result in hospitalization or death. We investigated associations between rare genetic variants and seven COVID-19 outcomes in 543,213 individuals, including 8,248 with COVID-19. After accounting for multiple testing, we did not identify any clear associations with rare variants either exome-wide or when specifically focusing on (i) 14 interferon pathway genes in which rare deleterious variants have been reported in severe COVID-19 patients; (ii) 167 genes located in COVID-19 GWAS risk loci; or (iii) 32 additional genes of immunologic relevance and/or therapeutic potential. Our analyses indicate there are no significant associations with rare protein-coding variants with detectable effect sizes at our current sample sizes. Analyses will be updated as additional data become available, with results publicly browsable at https://rgc-covid19.regeneron.com.

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