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Molecular Epidemiology of Aspergillus fumigatus in Chronic Pulmonary Aspergillosis Patients

Molecular fungal genotyping techniques developed and employed for epidemiological studies have understandably concentrated on establishing the genetic diversity of Aspergillus fumigatus in invasive aspergillosis due to its severity, the urgency for treatment, and the need to demonstrate possible sou...

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Autores principales: van der Torre, Mireille H., Shen, Hongwei, Rautemaa-Richardson, Riina, Richardson, Malcolm D., Novak-Frazer, Lilyann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924367/
https://www.ncbi.nlm.nih.gov/pubmed/33672698
http://dx.doi.org/10.3390/jof7020152
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author van der Torre, Mireille H.
Shen, Hongwei
Rautemaa-Richardson, Riina
Richardson, Malcolm D.
Novak-Frazer, Lilyann
author_facet van der Torre, Mireille H.
Shen, Hongwei
Rautemaa-Richardson, Riina
Richardson, Malcolm D.
Novak-Frazer, Lilyann
author_sort van der Torre, Mireille H.
collection PubMed
description Molecular fungal genotyping techniques developed and employed for epidemiological studies have understandably concentrated on establishing the genetic diversity of Aspergillus fumigatus in invasive aspergillosis due to its severity, the urgency for treatment, and the need to demonstrate possible sources. Some early studies suggested that these strains were phenotypically, if not genotypically, different from others. However, with improved discrimination and evaluations, incorporating environmental as well as clinical isolates from other Aspergillus conditions (e.g., chronic pulmonary aspergillosis and cystic fibrosis), this premise is no longer upheld. Moreover, with the onset of increased global triazole resistance, there has been a concerted effort to incorporate resistance profiling into genotyping studies and the realisation that the wider population of non-immunocompromised aspergillosis patients are at risk. This review summarises the developments in molecular genotyping studies that incorporate resistance profiling with attention to chronic pulmonary aspergillosis and an example of our UK experience.
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spelling pubmed-79243672021-03-03 Molecular Epidemiology of Aspergillus fumigatus in Chronic Pulmonary Aspergillosis Patients van der Torre, Mireille H. Shen, Hongwei Rautemaa-Richardson, Riina Richardson, Malcolm D. Novak-Frazer, Lilyann J Fungi (Basel) Review Molecular fungal genotyping techniques developed and employed for epidemiological studies have understandably concentrated on establishing the genetic diversity of Aspergillus fumigatus in invasive aspergillosis due to its severity, the urgency for treatment, and the need to demonstrate possible sources. Some early studies suggested that these strains were phenotypically, if not genotypically, different from others. However, with improved discrimination and evaluations, incorporating environmental as well as clinical isolates from other Aspergillus conditions (e.g., chronic pulmonary aspergillosis and cystic fibrosis), this premise is no longer upheld. Moreover, with the onset of increased global triazole resistance, there has been a concerted effort to incorporate resistance profiling into genotyping studies and the realisation that the wider population of non-immunocompromised aspergillosis patients are at risk. This review summarises the developments in molecular genotyping studies that incorporate resistance profiling with attention to chronic pulmonary aspergillosis and an example of our UK experience. MDPI 2021-02-20 /pmc/articles/PMC7924367/ /pubmed/33672698 http://dx.doi.org/10.3390/jof7020152 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
van der Torre, Mireille H.
Shen, Hongwei
Rautemaa-Richardson, Riina
Richardson, Malcolm D.
Novak-Frazer, Lilyann
Molecular Epidemiology of Aspergillus fumigatus in Chronic Pulmonary Aspergillosis Patients
title Molecular Epidemiology of Aspergillus fumigatus in Chronic Pulmonary Aspergillosis Patients
title_full Molecular Epidemiology of Aspergillus fumigatus in Chronic Pulmonary Aspergillosis Patients
title_fullStr Molecular Epidemiology of Aspergillus fumigatus in Chronic Pulmonary Aspergillosis Patients
title_full_unstemmed Molecular Epidemiology of Aspergillus fumigatus in Chronic Pulmonary Aspergillosis Patients
title_short Molecular Epidemiology of Aspergillus fumigatus in Chronic Pulmonary Aspergillosis Patients
title_sort molecular epidemiology of aspergillus fumigatus in chronic pulmonary aspergillosis patients
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924367/
https://www.ncbi.nlm.nih.gov/pubmed/33672698
http://dx.doi.org/10.3390/jof7020152
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