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Molecular Epidemiology of Aspergillus fumigatus in Chronic Pulmonary Aspergillosis Patients
Molecular fungal genotyping techniques developed and employed for epidemiological studies have understandably concentrated on establishing the genetic diversity of Aspergillus fumigatus in invasive aspergillosis due to its severity, the urgency for treatment, and the need to demonstrate possible sou...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924367/ https://www.ncbi.nlm.nih.gov/pubmed/33672698 http://dx.doi.org/10.3390/jof7020152 |
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author | van der Torre, Mireille H. Shen, Hongwei Rautemaa-Richardson, Riina Richardson, Malcolm D. Novak-Frazer, Lilyann |
author_facet | van der Torre, Mireille H. Shen, Hongwei Rautemaa-Richardson, Riina Richardson, Malcolm D. Novak-Frazer, Lilyann |
author_sort | van der Torre, Mireille H. |
collection | PubMed |
description | Molecular fungal genotyping techniques developed and employed for epidemiological studies have understandably concentrated on establishing the genetic diversity of Aspergillus fumigatus in invasive aspergillosis due to its severity, the urgency for treatment, and the need to demonstrate possible sources. Some early studies suggested that these strains were phenotypically, if not genotypically, different from others. However, with improved discrimination and evaluations, incorporating environmental as well as clinical isolates from other Aspergillus conditions (e.g., chronic pulmonary aspergillosis and cystic fibrosis), this premise is no longer upheld. Moreover, with the onset of increased global triazole resistance, there has been a concerted effort to incorporate resistance profiling into genotyping studies and the realisation that the wider population of non-immunocompromised aspergillosis patients are at risk. This review summarises the developments in molecular genotyping studies that incorporate resistance profiling with attention to chronic pulmonary aspergillosis and an example of our UK experience. |
format | Online Article Text |
id | pubmed-7924367 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79243672021-03-03 Molecular Epidemiology of Aspergillus fumigatus in Chronic Pulmonary Aspergillosis Patients van der Torre, Mireille H. Shen, Hongwei Rautemaa-Richardson, Riina Richardson, Malcolm D. Novak-Frazer, Lilyann J Fungi (Basel) Review Molecular fungal genotyping techniques developed and employed for epidemiological studies have understandably concentrated on establishing the genetic diversity of Aspergillus fumigatus in invasive aspergillosis due to its severity, the urgency for treatment, and the need to demonstrate possible sources. Some early studies suggested that these strains were phenotypically, if not genotypically, different from others. However, with improved discrimination and evaluations, incorporating environmental as well as clinical isolates from other Aspergillus conditions (e.g., chronic pulmonary aspergillosis and cystic fibrosis), this premise is no longer upheld. Moreover, with the onset of increased global triazole resistance, there has been a concerted effort to incorporate resistance profiling into genotyping studies and the realisation that the wider population of non-immunocompromised aspergillosis patients are at risk. This review summarises the developments in molecular genotyping studies that incorporate resistance profiling with attention to chronic pulmonary aspergillosis and an example of our UK experience. MDPI 2021-02-20 /pmc/articles/PMC7924367/ /pubmed/33672698 http://dx.doi.org/10.3390/jof7020152 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review van der Torre, Mireille H. Shen, Hongwei Rautemaa-Richardson, Riina Richardson, Malcolm D. Novak-Frazer, Lilyann Molecular Epidemiology of Aspergillus fumigatus in Chronic Pulmonary Aspergillosis Patients |
title | Molecular Epidemiology of Aspergillus fumigatus in Chronic Pulmonary Aspergillosis Patients |
title_full | Molecular Epidemiology of Aspergillus fumigatus in Chronic Pulmonary Aspergillosis Patients |
title_fullStr | Molecular Epidemiology of Aspergillus fumigatus in Chronic Pulmonary Aspergillosis Patients |
title_full_unstemmed | Molecular Epidemiology of Aspergillus fumigatus in Chronic Pulmonary Aspergillosis Patients |
title_short | Molecular Epidemiology of Aspergillus fumigatus in Chronic Pulmonary Aspergillosis Patients |
title_sort | molecular epidemiology of aspergillus fumigatus in chronic pulmonary aspergillosis patients |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924367/ https://www.ncbi.nlm.nih.gov/pubmed/33672698 http://dx.doi.org/10.3390/jof7020152 |
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