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Serum KL-6 Could Represent a Reliable Indicator of Unfavourable Outcome in Patients with COVID-19 Pneumonia
KL-6 is a sialoglycoprotein antigen which proved elevated in the serum of patients with different interstitial lung diseases, especially in those with a poorer outcome. Given that interstitial pneumonia is the most common presentation of SARS-CoV2 infection, we evaluated the prognostic role of KL-6...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924557/ https://www.ncbi.nlm.nih.gov/pubmed/33672761 http://dx.doi.org/10.3390/ijerph18042078 |
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author | Scotto, Riccardo Pinchera, Biagio Perna, Francesco Atripaldi, Lidia Giaccone, Agnese Sequino, Davide Zappulo, Emanuela Sardanelli, Alessia Schiano Moriello, Nicola Stanziola, Anna Bocchino, Marialuisa Gentile, Ivan Sanduzzi, Alessandro |
author_facet | Scotto, Riccardo Pinchera, Biagio Perna, Francesco Atripaldi, Lidia Giaccone, Agnese Sequino, Davide Zappulo, Emanuela Sardanelli, Alessia Schiano Moriello, Nicola Stanziola, Anna Bocchino, Marialuisa Gentile, Ivan Sanduzzi, Alessandro |
author_sort | Scotto, Riccardo |
collection | PubMed |
description | KL-6 is a sialoglycoprotein antigen which proved elevated in the serum of patients with different interstitial lung diseases, especially in those with a poorer outcome. Given that interstitial pneumonia is the most common presentation of SARS-CoV2 infection, we evaluated the prognostic role of KL-6 in patients with COVID-19 pneumonia. Patients with COVID-19 pneumonia were prospectively enrolled. Blood samples were collected at the time of enrolment (TOE) and on day 7 (T1). Serum KL-6 concentrations were measured by chemiluminescence enzyme immunoassay using a KL-6 antibody kit (LUMIPULSE G1200, Fujirebio) and the cut-off value was set at >1000 U/mL. Fifteen out of 34 enrolled patients (44.1%) died. Patients with unfavourable outcome showed significantly lower P/F ratio and higher IL-6 values and plasmatic concentrations of KL-6 at TOE compared with those who survived (median KL-6: 1188 U/mL vs. 260 U/mL, p < 0.001). KL-6 > 1000 U/mL resulted independently associated with death (aOR: 11.29, p < 0.05) with a positive predictive value of 83.3%. Our results suggest that KL-6 is a reliable indicator of pulmonary function and unfavourable outcome in patients with COVID-19 pneumonia. A KL-6 value > 1000 U/mL resulted independently associated with death and showed good accuracy in predicting a poorer outcome. KL-6 may thus represent a quick, inexpensive, and sensitive parameter to stratify the risk of severe respiratory failure and death. |
format | Online Article Text |
id | pubmed-7924557 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79245572021-03-03 Serum KL-6 Could Represent a Reliable Indicator of Unfavourable Outcome in Patients with COVID-19 Pneumonia Scotto, Riccardo Pinchera, Biagio Perna, Francesco Atripaldi, Lidia Giaccone, Agnese Sequino, Davide Zappulo, Emanuela Sardanelli, Alessia Schiano Moriello, Nicola Stanziola, Anna Bocchino, Marialuisa Gentile, Ivan Sanduzzi, Alessandro Int J Environ Res Public Health Article KL-6 is a sialoglycoprotein antigen which proved elevated in the serum of patients with different interstitial lung diseases, especially in those with a poorer outcome. Given that interstitial pneumonia is the most common presentation of SARS-CoV2 infection, we evaluated the prognostic role of KL-6 in patients with COVID-19 pneumonia. Patients with COVID-19 pneumonia were prospectively enrolled. Blood samples were collected at the time of enrolment (TOE) and on day 7 (T1). Serum KL-6 concentrations were measured by chemiluminescence enzyme immunoassay using a KL-6 antibody kit (LUMIPULSE G1200, Fujirebio) and the cut-off value was set at >1000 U/mL. Fifteen out of 34 enrolled patients (44.1%) died. Patients with unfavourable outcome showed significantly lower P/F ratio and higher IL-6 values and plasmatic concentrations of KL-6 at TOE compared with those who survived (median KL-6: 1188 U/mL vs. 260 U/mL, p < 0.001). KL-6 > 1000 U/mL resulted independently associated with death (aOR: 11.29, p < 0.05) with a positive predictive value of 83.3%. Our results suggest that KL-6 is a reliable indicator of pulmonary function and unfavourable outcome in patients with COVID-19 pneumonia. A KL-6 value > 1000 U/mL resulted independently associated with death and showed good accuracy in predicting a poorer outcome. KL-6 may thus represent a quick, inexpensive, and sensitive parameter to stratify the risk of severe respiratory failure and death. MDPI 2021-02-20 2021-02 /pmc/articles/PMC7924557/ /pubmed/33672761 http://dx.doi.org/10.3390/ijerph18042078 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Scotto, Riccardo Pinchera, Biagio Perna, Francesco Atripaldi, Lidia Giaccone, Agnese Sequino, Davide Zappulo, Emanuela Sardanelli, Alessia Schiano Moriello, Nicola Stanziola, Anna Bocchino, Marialuisa Gentile, Ivan Sanduzzi, Alessandro Serum KL-6 Could Represent a Reliable Indicator of Unfavourable Outcome in Patients with COVID-19 Pneumonia |
title | Serum KL-6 Could Represent a Reliable Indicator of Unfavourable Outcome in Patients with COVID-19 Pneumonia |
title_full | Serum KL-6 Could Represent a Reliable Indicator of Unfavourable Outcome in Patients with COVID-19 Pneumonia |
title_fullStr | Serum KL-6 Could Represent a Reliable Indicator of Unfavourable Outcome in Patients with COVID-19 Pneumonia |
title_full_unstemmed | Serum KL-6 Could Represent a Reliable Indicator of Unfavourable Outcome in Patients with COVID-19 Pneumonia |
title_short | Serum KL-6 Could Represent a Reliable Indicator of Unfavourable Outcome in Patients with COVID-19 Pneumonia |
title_sort | serum kl-6 could represent a reliable indicator of unfavourable outcome in patients with covid-19 pneumonia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924557/ https://www.ncbi.nlm.nih.gov/pubmed/33672761 http://dx.doi.org/10.3390/ijerph18042078 |
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