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Efficacy of Oral Vaccine against Classical Swine Fever in Wild Boar and Estimation of the Disease Dynamics in the Quantitative Approach

Classical swine fever virus (CSFV) in the wild boar population has been spreading in Japan, alongside outbreaks on pigs, since classical swine fever (CSF) reemerged in September 2018. The vaccination using oral bait vaccine was initially implemented in Gifu prefecture in March 2019. In the present s...

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Autores principales: Bazarragchaa, Enkhbold, Isoda, Norikazu, Kim, Taksoo, Tetsuo, Madoka, Ito, Satoshi, Matsuno, Keita, Sakoda, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924559/
https://www.ncbi.nlm.nih.gov/pubmed/33672749
http://dx.doi.org/10.3390/v13020319
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author Bazarragchaa, Enkhbold
Isoda, Norikazu
Kim, Taksoo
Tetsuo, Madoka
Ito, Satoshi
Matsuno, Keita
Sakoda, Yoshihiro
author_facet Bazarragchaa, Enkhbold
Isoda, Norikazu
Kim, Taksoo
Tetsuo, Madoka
Ito, Satoshi
Matsuno, Keita
Sakoda, Yoshihiro
author_sort Bazarragchaa, Enkhbold
collection PubMed
description Classical swine fever virus (CSFV) in the wild boar population has been spreading in Japan, alongside outbreaks on pigs, since classical swine fever (CSF) reemerged in September 2018. The vaccination using oral bait vaccine was initially implemented in Gifu prefecture in March 2019. In the present study, antibodies against CSFV in wild boar were assessed in 1443 captured and dead wild boars in Gifu prefecture. After the implementation of oral vaccination, the increase of the proportion of seropositive animals and their titer in wild boars were confirmed. Quantitative analysis of antigen and antibodies against CSFV in wild boar implies potential disease diversity in the wild boar population. Animals with status in high virus replication (Ct < 30) and non- or low-immune response were confirmed and were sustained at a certain level after initial oral vaccination. Through continuous vaccination periods, the increase of seroprevalence among wild boar and the decrease of CSFV-positive animals were observed. The epidemiological analysis based on the quantitative virological outcomes could provide more information on the efficacy of oral vaccination and dynamics of CSF in the wild boar population, which will help to improve the implementation of control measures for CSF in countries such as Japan and neighboring countries.
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spelling pubmed-79245592021-03-03 Efficacy of Oral Vaccine against Classical Swine Fever in Wild Boar and Estimation of the Disease Dynamics in the Quantitative Approach Bazarragchaa, Enkhbold Isoda, Norikazu Kim, Taksoo Tetsuo, Madoka Ito, Satoshi Matsuno, Keita Sakoda, Yoshihiro Viruses Article Classical swine fever virus (CSFV) in the wild boar population has been spreading in Japan, alongside outbreaks on pigs, since classical swine fever (CSF) reemerged in September 2018. The vaccination using oral bait vaccine was initially implemented in Gifu prefecture in March 2019. In the present study, antibodies against CSFV in wild boar were assessed in 1443 captured and dead wild boars in Gifu prefecture. After the implementation of oral vaccination, the increase of the proportion of seropositive animals and their titer in wild boars were confirmed. Quantitative analysis of antigen and antibodies against CSFV in wild boar implies potential disease diversity in the wild boar population. Animals with status in high virus replication (Ct < 30) and non- or low-immune response were confirmed and were sustained at a certain level after initial oral vaccination. Through continuous vaccination periods, the increase of seroprevalence among wild boar and the decrease of CSFV-positive animals were observed. The epidemiological analysis based on the quantitative virological outcomes could provide more information on the efficacy of oral vaccination and dynamics of CSF in the wild boar population, which will help to improve the implementation of control measures for CSF in countries such as Japan and neighboring countries. MDPI 2021-02-20 /pmc/articles/PMC7924559/ /pubmed/33672749 http://dx.doi.org/10.3390/v13020319 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bazarragchaa, Enkhbold
Isoda, Norikazu
Kim, Taksoo
Tetsuo, Madoka
Ito, Satoshi
Matsuno, Keita
Sakoda, Yoshihiro
Efficacy of Oral Vaccine against Classical Swine Fever in Wild Boar and Estimation of the Disease Dynamics in the Quantitative Approach
title Efficacy of Oral Vaccine against Classical Swine Fever in Wild Boar and Estimation of the Disease Dynamics in the Quantitative Approach
title_full Efficacy of Oral Vaccine against Classical Swine Fever in Wild Boar and Estimation of the Disease Dynamics in the Quantitative Approach
title_fullStr Efficacy of Oral Vaccine against Classical Swine Fever in Wild Boar and Estimation of the Disease Dynamics in the Quantitative Approach
title_full_unstemmed Efficacy of Oral Vaccine against Classical Swine Fever in Wild Boar and Estimation of the Disease Dynamics in the Quantitative Approach
title_short Efficacy of Oral Vaccine against Classical Swine Fever in Wild Boar and Estimation of the Disease Dynamics in the Quantitative Approach
title_sort efficacy of oral vaccine against classical swine fever in wild boar and estimation of the disease dynamics in the quantitative approach
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924559/
https://www.ncbi.nlm.nih.gov/pubmed/33672749
http://dx.doi.org/10.3390/v13020319
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