Cargando…
Efficacy of Oral Vaccine against Classical Swine Fever in Wild Boar and Estimation of the Disease Dynamics in the Quantitative Approach
Classical swine fever virus (CSFV) in the wild boar population has been spreading in Japan, alongside outbreaks on pigs, since classical swine fever (CSF) reemerged in September 2018. The vaccination using oral bait vaccine was initially implemented in Gifu prefecture in March 2019. In the present s...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924559/ https://www.ncbi.nlm.nih.gov/pubmed/33672749 http://dx.doi.org/10.3390/v13020319 |
_version_ | 1783659114526670848 |
---|---|
author | Bazarragchaa, Enkhbold Isoda, Norikazu Kim, Taksoo Tetsuo, Madoka Ito, Satoshi Matsuno, Keita Sakoda, Yoshihiro |
author_facet | Bazarragchaa, Enkhbold Isoda, Norikazu Kim, Taksoo Tetsuo, Madoka Ito, Satoshi Matsuno, Keita Sakoda, Yoshihiro |
author_sort | Bazarragchaa, Enkhbold |
collection | PubMed |
description | Classical swine fever virus (CSFV) in the wild boar population has been spreading in Japan, alongside outbreaks on pigs, since classical swine fever (CSF) reemerged in September 2018. The vaccination using oral bait vaccine was initially implemented in Gifu prefecture in March 2019. In the present study, antibodies against CSFV in wild boar were assessed in 1443 captured and dead wild boars in Gifu prefecture. After the implementation of oral vaccination, the increase of the proportion of seropositive animals and their titer in wild boars were confirmed. Quantitative analysis of antigen and antibodies against CSFV in wild boar implies potential disease diversity in the wild boar population. Animals with status in high virus replication (Ct < 30) and non- or low-immune response were confirmed and were sustained at a certain level after initial oral vaccination. Through continuous vaccination periods, the increase of seroprevalence among wild boar and the decrease of CSFV-positive animals were observed. The epidemiological analysis based on the quantitative virological outcomes could provide more information on the efficacy of oral vaccination and dynamics of CSF in the wild boar population, which will help to improve the implementation of control measures for CSF in countries such as Japan and neighboring countries. |
format | Online Article Text |
id | pubmed-7924559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79245592021-03-03 Efficacy of Oral Vaccine against Classical Swine Fever in Wild Boar and Estimation of the Disease Dynamics in the Quantitative Approach Bazarragchaa, Enkhbold Isoda, Norikazu Kim, Taksoo Tetsuo, Madoka Ito, Satoshi Matsuno, Keita Sakoda, Yoshihiro Viruses Article Classical swine fever virus (CSFV) in the wild boar population has been spreading in Japan, alongside outbreaks on pigs, since classical swine fever (CSF) reemerged in September 2018. The vaccination using oral bait vaccine was initially implemented in Gifu prefecture in March 2019. In the present study, antibodies against CSFV in wild boar were assessed in 1443 captured and dead wild boars in Gifu prefecture. After the implementation of oral vaccination, the increase of the proportion of seropositive animals and their titer in wild boars were confirmed. Quantitative analysis of antigen and antibodies against CSFV in wild boar implies potential disease diversity in the wild boar population. Animals with status in high virus replication (Ct < 30) and non- or low-immune response were confirmed and were sustained at a certain level after initial oral vaccination. Through continuous vaccination periods, the increase of seroprevalence among wild boar and the decrease of CSFV-positive animals were observed. The epidemiological analysis based on the quantitative virological outcomes could provide more information on the efficacy of oral vaccination and dynamics of CSF in the wild boar population, which will help to improve the implementation of control measures for CSF in countries such as Japan and neighboring countries. MDPI 2021-02-20 /pmc/articles/PMC7924559/ /pubmed/33672749 http://dx.doi.org/10.3390/v13020319 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bazarragchaa, Enkhbold Isoda, Norikazu Kim, Taksoo Tetsuo, Madoka Ito, Satoshi Matsuno, Keita Sakoda, Yoshihiro Efficacy of Oral Vaccine against Classical Swine Fever in Wild Boar and Estimation of the Disease Dynamics in the Quantitative Approach |
title | Efficacy of Oral Vaccine against Classical Swine Fever in Wild Boar and Estimation of the Disease Dynamics in the Quantitative Approach |
title_full | Efficacy of Oral Vaccine against Classical Swine Fever in Wild Boar and Estimation of the Disease Dynamics in the Quantitative Approach |
title_fullStr | Efficacy of Oral Vaccine against Classical Swine Fever in Wild Boar and Estimation of the Disease Dynamics in the Quantitative Approach |
title_full_unstemmed | Efficacy of Oral Vaccine against Classical Swine Fever in Wild Boar and Estimation of the Disease Dynamics in the Quantitative Approach |
title_short | Efficacy of Oral Vaccine against Classical Swine Fever in Wild Boar and Estimation of the Disease Dynamics in the Quantitative Approach |
title_sort | efficacy of oral vaccine against classical swine fever in wild boar and estimation of the disease dynamics in the quantitative approach |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924559/ https://www.ncbi.nlm.nih.gov/pubmed/33672749 http://dx.doi.org/10.3390/v13020319 |
work_keys_str_mv | AT bazarragchaaenkhbold efficacyoforalvaccineagainstclassicalswinefeverinwildboarandestimationofthediseasedynamicsinthequantitativeapproach AT isodanorikazu efficacyoforalvaccineagainstclassicalswinefeverinwildboarandestimationofthediseasedynamicsinthequantitativeapproach AT kimtaksoo efficacyoforalvaccineagainstclassicalswinefeverinwildboarandestimationofthediseasedynamicsinthequantitativeapproach AT tetsuomadoka efficacyoforalvaccineagainstclassicalswinefeverinwildboarandestimationofthediseasedynamicsinthequantitativeapproach AT itosatoshi efficacyoforalvaccineagainstclassicalswinefeverinwildboarandestimationofthediseasedynamicsinthequantitativeapproach AT matsunokeita efficacyoforalvaccineagainstclassicalswinefeverinwildboarandestimationofthediseasedynamicsinthequantitativeapproach AT sakodayoshihiro efficacyoforalvaccineagainstclassicalswinefeverinwildboarandestimationofthediseasedynamicsinthequantitativeapproach |