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Thrombocytopenia in Virus Infections
Thrombocytopenia, which signifies a low platelet count usually below 150 × 10(9)/L, is a common finding following or during many viral infections. In clinical medicine, mild thrombocytopenia, combined with lymphopenia in a patient with signs and symptoms of an infectious disease, raises the suspicio...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924611/ https://www.ncbi.nlm.nih.gov/pubmed/33672766 http://dx.doi.org/10.3390/jcm10040877 |
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author | Raadsen, Matthijs Du Toit, Justin Langerak, Thomas van Bussel, Bas van Gorp, Eric Goeijenbier, Marco |
author_facet | Raadsen, Matthijs Du Toit, Justin Langerak, Thomas van Bussel, Bas van Gorp, Eric Goeijenbier, Marco |
author_sort | Raadsen, Matthijs |
collection | PubMed |
description | Thrombocytopenia, which signifies a low platelet count usually below 150 × 10(9)/L, is a common finding following or during many viral infections. In clinical medicine, mild thrombocytopenia, combined with lymphopenia in a patient with signs and symptoms of an infectious disease, raises the suspicion of a viral infection. This phenomenon is classically attributed to platelet consumption due to inflammation-induced coagulation, sequestration from the circulation by phagocytosis and hypersplenism, and impaired platelet production due to defective megakaryopoiesis or cytokine-induced myelosuppression. All these mechanisms, while plausible and supported by substantial evidence, regard platelets as passive bystanders during viral infection. However, platelets are increasingly recognized as active players in the (antiviral) immune response and have been shown to interact with cells of the innate and adaptive immune system as well as directly with viruses. These findings can be of interest both for understanding the pathogenesis of viral infectious diseases and predicting outcome. In this review, we will summarize and discuss the literature currently available on various mechanisms within the relationship between thrombocytopenia and virus infections. |
format | Online Article Text |
id | pubmed-7924611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79246112021-03-03 Thrombocytopenia in Virus Infections Raadsen, Matthijs Du Toit, Justin Langerak, Thomas van Bussel, Bas van Gorp, Eric Goeijenbier, Marco J Clin Med Review Thrombocytopenia, which signifies a low platelet count usually below 150 × 10(9)/L, is a common finding following or during many viral infections. In clinical medicine, mild thrombocytopenia, combined with lymphopenia in a patient with signs and symptoms of an infectious disease, raises the suspicion of a viral infection. This phenomenon is classically attributed to platelet consumption due to inflammation-induced coagulation, sequestration from the circulation by phagocytosis and hypersplenism, and impaired platelet production due to defective megakaryopoiesis or cytokine-induced myelosuppression. All these mechanisms, while plausible and supported by substantial evidence, regard platelets as passive bystanders during viral infection. However, platelets are increasingly recognized as active players in the (antiviral) immune response and have been shown to interact with cells of the innate and adaptive immune system as well as directly with viruses. These findings can be of interest both for understanding the pathogenesis of viral infectious diseases and predicting outcome. In this review, we will summarize and discuss the literature currently available on various mechanisms within the relationship between thrombocytopenia and virus infections. MDPI 2021-02-20 /pmc/articles/PMC7924611/ /pubmed/33672766 http://dx.doi.org/10.3390/jcm10040877 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Raadsen, Matthijs Du Toit, Justin Langerak, Thomas van Bussel, Bas van Gorp, Eric Goeijenbier, Marco Thrombocytopenia in Virus Infections |
title | Thrombocytopenia in Virus Infections |
title_full | Thrombocytopenia in Virus Infections |
title_fullStr | Thrombocytopenia in Virus Infections |
title_full_unstemmed | Thrombocytopenia in Virus Infections |
title_short | Thrombocytopenia in Virus Infections |
title_sort | thrombocytopenia in virus infections |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924611/ https://www.ncbi.nlm.nih.gov/pubmed/33672766 http://dx.doi.org/10.3390/jcm10040877 |
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