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RIdeogram: drawing SVG graphics to visualize and map genome-wide data on the idiograms

BACKGROUND: Owing to the rapid advances in DNA sequencing technologies, whole genome from more and more species are becoming available at increasing pace. For whole-genome analysis, idiograms provide a very popular, intuitive and effective way to map and visualize the genome-wide information, such a...

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Autores principales: Hao, Zhaodong, Lv, Dekang, Ge, Ying, Shi, Jisen, Weijers, Dolf, Yu, Guangchuang, Chen, Jinhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924719/
https://www.ncbi.nlm.nih.gov/pubmed/33816903
http://dx.doi.org/10.7717/peerj-cs.251
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author Hao, Zhaodong
Lv, Dekang
Ge, Ying
Shi, Jisen
Weijers, Dolf
Yu, Guangchuang
Chen, Jinhui
author_facet Hao, Zhaodong
Lv, Dekang
Ge, Ying
Shi, Jisen
Weijers, Dolf
Yu, Guangchuang
Chen, Jinhui
author_sort Hao, Zhaodong
collection PubMed
description BACKGROUND: Owing to the rapid advances in DNA sequencing technologies, whole genome from more and more species are becoming available at increasing pace. For whole-genome analysis, idiograms provide a very popular, intuitive and effective way to map and visualize the genome-wide information, such as GC content, gene and repeat density, DNA methylation distribution, genomic synteny, etc. However, most available software programs and web servers are available only for a few model species, such as human, mouse and fly, or have limited application scenarios. As more and more non-model species are sequenced with chromosome-level assembly being available, tools that can generate idiograms for a broad range of species and be capable of visualizing more data types are needed to help better understanding fundamental genome characteristics. RESULTS: The R package RIdeogram allows users to build high-quality idiograms of any species of interest. It can map continuous and discrete genome-wide data on the idiograms and visualize them in a heat map and track labels, respectively. CONCLUSION: The visualization of genome-wide data mapping and comparison allow users to quickly establish a clear impression of the chromosomal distribution pattern, thus making RIdeogram a useful tool for any researchers working with omics.
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spelling pubmed-79247192021-04-02 RIdeogram: drawing SVG graphics to visualize and map genome-wide data on the idiograms Hao, Zhaodong Lv, Dekang Ge, Ying Shi, Jisen Weijers, Dolf Yu, Guangchuang Chen, Jinhui PeerJ Comput Sci Bioinformatics BACKGROUND: Owing to the rapid advances in DNA sequencing technologies, whole genome from more and more species are becoming available at increasing pace. For whole-genome analysis, idiograms provide a very popular, intuitive and effective way to map and visualize the genome-wide information, such as GC content, gene and repeat density, DNA methylation distribution, genomic synteny, etc. However, most available software programs and web servers are available only for a few model species, such as human, mouse and fly, or have limited application scenarios. As more and more non-model species are sequenced with chromosome-level assembly being available, tools that can generate idiograms for a broad range of species and be capable of visualizing more data types are needed to help better understanding fundamental genome characteristics. RESULTS: The R package RIdeogram allows users to build high-quality idiograms of any species of interest. It can map continuous and discrete genome-wide data on the idiograms and visualize them in a heat map and track labels, respectively. CONCLUSION: The visualization of genome-wide data mapping and comparison allow users to quickly establish a clear impression of the chromosomal distribution pattern, thus making RIdeogram a useful tool for any researchers working with omics. PeerJ Inc. 2020-01-20 /pmc/articles/PMC7924719/ /pubmed/33816903 http://dx.doi.org/10.7717/peerj-cs.251 Text en ©2020 Hao et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ Computer Science) and either DOI or URL of the article must be cited.
spellingShingle Bioinformatics
Hao, Zhaodong
Lv, Dekang
Ge, Ying
Shi, Jisen
Weijers, Dolf
Yu, Guangchuang
Chen, Jinhui
RIdeogram: drawing SVG graphics to visualize and map genome-wide data on the idiograms
title RIdeogram: drawing SVG graphics to visualize and map genome-wide data on the idiograms
title_full RIdeogram: drawing SVG graphics to visualize and map genome-wide data on the idiograms
title_fullStr RIdeogram: drawing SVG graphics to visualize and map genome-wide data on the idiograms
title_full_unstemmed RIdeogram: drawing SVG graphics to visualize and map genome-wide data on the idiograms
title_short RIdeogram: drawing SVG graphics to visualize and map genome-wide data on the idiograms
title_sort rideogram: drawing svg graphics to visualize and map genome-wide data on the idiograms
topic Bioinformatics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924719/
https://www.ncbi.nlm.nih.gov/pubmed/33816903
http://dx.doi.org/10.7717/peerj-cs.251
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