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Role of Antimicrobial Susceptibility Testing before First-Line Treatment Containing Clarithromycin for Helicobacter pylori Eradication in the Clinical Setting

Background: Checking Helicobacter pylori susceptibility tests in the clinical setting before first-line treatment is considered difficult. We compared susceptibility-guided therapy (SGT) with empirical therapy (ET) as a first-line treatment containing clarithromycin and investigated the eradication...

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Autores principales: Kang, Seokin, Kim, Yuri, Ahn, Ji Yong, Jung, Hwoon-Yong, Kim, Nayoung, Na, Hee Kyong, Lee, Jeong Hoon, Jung, Kee Wook, Kim, Do Hoon, Choi, Kee Don, Song, Ho June, Lee, Gin Hyug
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924850/
https://www.ncbi.nlm.nih.gov/pubmed/33669969
http://dx.doi.org/10.3390/antibiotics10020214
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author Kang, Seokin
Kim, Yuri
Ahn, Ji Yong
Jung, Hwoon-Yong
Kim, Nayoung
Na, Hee Kyong
Lee, Jeong Hoon
Jung, Kee Wook
Kim, Do Hoon
Choi, Kee Don
Song, Ho June
Lee, Gin Hyug
author_facet Kang, Seokin
Kim, Yuri
Ahn, Ji Yong
Jung, Hwoon-Yong
Kim, Nayoung
Na, Hee Kyong
Lee, Jeong Hoon
Jung, Kee Wook
Kim, Do Hoon
Choi, Kee Don
Song, Ho June
Lee, Gin Hyug
author_sort Kang, Seokin
collection PubMed
description Background: Checking Helicobacter pylori susceptibility tests in the clinical setting before first-line treatment is considered difficult. We compared susceptibility-guided therapy (SGT) with empirical therapy (ET) as a first-line treatment containing clarithromycin and investigated the eradication rate using antimicrobial susceptibility testing (AST). Methods: 257 patients with H. pylori infection, with AST, performed before the eradication of clarithromycin-containing regimens were enrolled and divided into two groups: the SGT and ET groups. Results: Eradication rates in the SGT and ET groups were 85.4% and 58.4% (P < 0.01), respectively. In triple therapy (TT), eradication rates of the SGT and ET groups were 85.1% and 56.6% (P < 0.01), respectively. In sequential therapy (SET), eradication rates of the SGT and ET groups were 86.2% and 65.6% (P = 0.06), respectively. According to AST, TT had an eradication rate of 84.6% with strains susceptible to clarithromycin and amoxicillin and 11.1% with strains resistant to both. SET had an eradication rate of 89.5% with strains susceptible to clarithromycin, amoxicillin, and metronidazole, whereas it was 0% with strains resistant to clarithromycin and metronidazole. Conclusions: SGT as first-line treatment improved eradication rates of TT and SET by 28.5 (P < 0.01) and 20.6 (P = 0.06) percent points, respectively, compared with ET.
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spelling pubmed-79248502021-03-03 Role of Antimicrobial Susceptibility Testing before First-Line Treatment Containing Clarithromycin for Helicobacter pylori Eradication in the Clinical Setting Kang, Seokin Kim, Yuri Ahn, Ji Yong Jung, Hwoon-Yong Kim, Nayoung Na, Hee Kyong Lee, Jeong Hoon Jung, Kee Wook Kim, Do Hoon Choi, Kee Don Song, Ho June Lee, Gin Hyug Antibiotics (Basel) Article Background: Checking Helicobacter pylori susceptibility tests in the clinical setting before first-line treatment is considered difficult. We compared susceptibility-guided therapy (SGT) with empirical therapy (ET) as a first-line treatment containing clarithromycin and investigated the eradication rate using antimicrobial susceptibility testing (AST). Methods: 257 patients with H. pylori infection, with AST, performed before the eradication of clarithromycin-containing regimens were enrolled and divided into two groups: the SGT and ET groups. Results: Eradication rates in the SGT and ET groups were 85.4% and 58.4% (P < 0.01), respectively. In triple therapy (TT), eradication rates of the SGT and ET groups were 85.1% and 56.6% (P < 0.01), respectively. In sequential therapy (SET), eradication rates of the SGT and ET groups were 86.2% and 65.6% (P = 0.06), respectively. According to AST, TT had an eradication rate of 84.6% with strains susceptible to clarithromycin and amoxicillin and 11.1% with strains resistant to both. SET had an eradication rate of 89.5% with strains susceptible to clarithromycin, amoxicillin, and metronidazole, whereas it was 0% with strains resistant to clarithromycin and metronidazole. Conclusions: SGT as first-line treatment improved eradication rates of TT and SET by 28.5 (P < 0.01) and 20.6 (P = 0.06) percent points, respectively, compared with ET. MDPI 2021-02-21 /pmc/articles/PMC7924850/ /pubmed/33669969 http://dx.doi.org/10.3390/antibiotics10020214 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kang, Seokin
Kim, Yuri
Ahn, Ji Yong
Jung, Hwoon-Yong
Kim, Nayoung
Na, Hee Kyong
Lee, Jeong Hoon
Jung, Kee Wook
Kim, Do Hoon
Choi, Kee Don
Song, Ho June
Lee, Gin Hyug
Role of Antimicrobial Susceptibility Testing before First-Line Treatment Containing Clarithromycin for Helicobacter pylori Eradication in the Clinical Setting
title Role of Antimicrobial Susceptibility Testing before First-Line Treatment Containing Clarithromycin for Helicobacter pylori Eradication in the Clinical Setting
title_full Role of Antimicrobial Susceptibility Testing before First-Line Treatment Containing Clarithromycin for Helicobacter pylori Eradication in the Clinical Setting
title_fullStr Role of Antimicrobial Susceptibility Testing before First-Line Treatment Containing Clarithromycin for Helicobacter pylori Eradication in the Clinical Setting
title_full_unstemmed Role of Antimicrobial Susceptibility Testing before First-Line Treatment Containing Clarithromycin for Helicobacter pylori Eradication in the Clinical Setting
title_short Role of Antimicrobial Susceptibility Testing before First-Line Treatment Containing Clarithromycin for Helicobacter pylori Eradication in the Clinical Setting
title_sort role of antimicrobial susceptibility testing before first-line treatment containing clarithromycin for helicobacter pylori eradication in the clinical setting
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924850/
https://www.ncbi.nlm.nih.gov/pubmed/33669969
http://dx.doi.org/10.3390/antibiotics10020214
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