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Mapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum

Falciparum malaria is clinically heterogeneous and the relative contribution of parasite and host in shaping disease severity remains unclear. We explored the interaction between inflammation and parasite variant surface antigen (VSA) expression, asking whether this relationship underpins the variat...

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Detalles Bibliográficos
Autores principales: Milne, Kathryn, Ivens, Alasdair, Reid, Adam J, Lotkowska, Magda E, O'Toole, Aine, Sankaranarayanan, Geetha, Munoz Sandoval, Diana, Nahrendorf, Wiebke, Regnault, Clement, Edwards, Nick J, Silk, Sarah E, Payne, Ruth O, Minassian, Angela M, Venkatraman, Navin, Sanders, Mandy J, Hill, Adrian VS, Barrett, Michael, Berriman, Matthew, Draper, Simon J, Rowe, J Alexandra, Spence, Philip J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924948/
https://www.ncbi.nlm.nih.gov/pubmed/33648633
http://dx.doi.org/10.7554/eLife.62800