Inhibition of RAF dimers: it takes two to tango

The RAS-regulated RAF–MEK1/2–ERK1/2 pathway promotes cell proliferation and survival and RAS and BRAF proteins are commonly mutated in cancer. This has fuelled the development of small molecule kinase inhibitors including ATP-competitive RAF inhibitors. Type I and type I½ ATP-competitive RAF inhibit...

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Detalles Bibliográficos
Autores principales: Cook, Frazer A., Cook, Simon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924995/
https://www.ncbi.nlm.nih.gov/pubmed/33367512
http://dx.doi.org/10.1042/BST20200485

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