Two Sides of a Coin: a Zika Virus Mutation Selected in Pregnant Rhesus Macaques Promotes Fetal Infection in Mice but at a Cost of Reduced Fitness in Nonpregnant Macaques and Diminished Transmissibility by Vectors

Although fetal death is now understood to be a severe outcome of congenital Zika syndrome, the role of viral genetics is still unclear. We sequenced Zika virus (ZIKV) from a rhesus macaque fetus that died after inoculation and identified a single intrahost substitution, M1404I, in the ZIKV polyprote...

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Detalles Bibliográficos
Autores principales: Lemos, Danilo, Stuart, Jackson B., Louie, William, Singapuri, Anil, Ramírez, Ana L., Watanabe, Jennifer, Usachenko, Jodie, Keesler, Rebekah I., Sanchez-San Martin, Claudia, Li, Tony, Martyn, Calla, Oliveira, Glenn, Saraf, Sharada, Grubaugh, Nathan D., Andersen, Kristian G., Thissen, James, Allen, Jonathan, Borucki, Monica, Tsetsarkin, Konstantin A., Pletnev, Alexander G., Chiu, Charles Y., Van Rompay, Koen K. A., Coffey, Lark L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Genetic Diversity and Evolution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925200/
https://www.ncbi.nlm.nih.gov/pubmed/32999034
http://dx.doi.org/10.1128/JVI.01605-20

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