The Cytokine Expression in Patients with Cardiac Complication after Immune Checkpoint Inhibitor Therapy

We herein report the cytokine expression at different stages for three patients who developed cardiac complications after immune checkpoint inhibitor (ICI) therapy. Case 1 with biopsy-proven myocarditis showed increased levels of interleukin (IL)-8, monocyte chemotactic and activating factor, and gr...

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Detalles Bibliográficos
Autores principales: Tsuruda, Toshihiro, Yoshikawa, Naoki, Kai, Motoaki, Yamaguchi, Masashi, Toida, Reiko, Kodama, Tsuyoshi, Kajihara, Kei, Kawabata, Takayuki, Nakamura, Takeshi, Sakata, Koji, Hatakeyama, Kinta, Gi, Toshihiro, Asada, Yujiro, Tono, Tetsuya, Kitamura, Kazuo, Ikeda, Ryuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925267/
https://www.ncbi.nlm.nih.gov/pubmed/32963156
http://dx.doi.org/10.2169/internalmedicine.5317-20
Descripción
Sumario:We herein report the cytokine expression at different stages for three patients who developed cardiac complications after immune checkpoint inhibitor (ICI) therapy. Case 1 with biopsy-proven myocarditis showed increased levels of interleukin (IL)-8, monocyte chemotactic and activating factor, and granulocyte macrophage colony-stimulating factor (GM-CSF) when he developed Takotsubo cardiomyopathy. Case 2 with subclinical myocarditis showed predominant activation of IL-8 during the progressive clinical course. Case 3 with cytokine-releasing syndrome showed substantial activations of IL-6, IL-8, GM-CSF, and interferon-γ. Our data suggest the development of unique cytokine activation in individual patients with cardiac complications after ICI therapy.

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