The Development of Foveolar-type Gastric Adenocarcinoma during Maintenance Therapy of Vonoprazan for Reflux Esophagitis

We herein report the first case of foveolar-type gastric adenocarcinoma that developed after the initiation of vonoprazan (VPZ). A 51-year-old man had heartburn at the first visit and reflux esophagitis endoscopically, so he started taking VPZ. An approximately 5-mm-sized reddish polyp with a raspbe...

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Autores principales: Saito, Masahiro, Koike, Tomoyuki, Abe, Yasuaki, Nakagawa, Kenichiro, Kanno, Takeshi, Jin, Xiaoyi, Hatta, Waku, Uno, Kaname, Asano, Naoki, Imatani, Akira, Fujishima, Fumiyoshi, Masamune, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925268/
https://www.ncbi.nlm.nih.gov/pubmed/32863366
http://dx.doi.org/10.2169/internalmedicine.5431-20
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author Saito, Masahiro
Koike, Tomoyuki
Abe, Yasuaki
Nakagawa, Kenichiro
Kanno, Takeshi
Jin, Xiaoyi
Hatta, Waku
Uno, Kaname
Asano, Naoki
Imatani, Akira
Fujishima, Fumiyoshi
Masamune, Atsushi
author_facet Saito, Masahiro
Koike, Tomoyuki
Abe, Yasuaki
Nakagawa, Kenichiro
Kanno, Takeshi
Jin, Xiaoyi
Hatta, Waku
Uno, Kaname
Asano, Naoki
Imatani, Akira
Fujishima, Fumiyoshi
Masamune, Atsushi
author_sort Saito, Masahiro
collection PubMed
description We herein report the first case of foveolar-type gastric adenocarcinoma that developed after the initiation of vonoprazan (VPZ). A 51-year-old man had heartburn at the first visit and reflux esophagitis endoscopically, so he started taking VPZ. An approximately 5-mm-sized reddish polyp with a raspberry-like morphology was detected at the anterior wall of the upper body of the stomach 156 weeks after starting maintenance therapy with VPZ 10 mg/day. It was diagnosed as foveolar-type gastric adenocarcinoma based on a biopsy. Another approximately 4-mm-sized foveolar-type gastric adenocarcinoma was also detected at the posterior wall of the middle body of the stomach.
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spelling pubmed-79252682021-03-10 The Development of Foveolar-type Gastric Adenocarcinoma during Maintenance Therapy of Vonoprazan for Reflux Esophagitis Saito, Masahiro Koike, Tomoyuki Abe, Yasuaki Nakagawa, Kenichiro Kanno, Takeshi Jin, Xiaoyi Hatta, Waku Uno, Kaname Asano, Naoki Imatani, Akira Fujishima, Fumiyoshi Masamune, Atsushi Intern Med Case Report We herein report the first case of foveolar-type gastric adenocarcinoma that developed after the initiation of vonoprazan (VPZ). A 51-year-old man had heartburn at the first visit and reflux esophagitis endoscopically, so he started taking VPZ. An approximately 5-mm-sized reddish polyp with a raspberry-like morphology was detected at the anterior wall of the upper body of the stomach 156 weeks after starting maintenance therapy with VPZ 10 mg/day. It was diagnosed as foveolar-type gastric adenocarcinoma based on a biopsy. Another approximately 4-mm-sized foveolar-type gastric adenocarcinoma was also detected at the posterior wall of the middle body of the stomach. The Japanese Society of Internal Medicine 2020-08-29 2021-02-01 /pmc/articles/PMC7925268/ /pubmed/32863366 http://dx.doi.org/10.2169/internalmedicine.5431-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Saito, Masahiro
Koike, Tomoyuki
Abe, Yasuaki
Nakagawa, Kenichiro
Kanno, Takeshi
Jin, Xiaoyi
Hatta, Waku
Uno, Kaname
Asano, Naoki
Imatani, Akira
Fujishima, Fumiyoshi
Masamune, Atsushi
The Development of Foveolar-type Gastric Adenocarcinoma during Maintenance Therapy of Vonoprazan for Reflux Esophagitis
title The Development of Foveolar-type Gastric Adenocarcinoma during Maintenance Therapy of Vonoprazan for Reflux Esophagitis
title_full The Development of Foveolar-type Gastric Adenocarcinoma during Maintenance Therapy of Vonoprazan for Reflux Esophagitis
title_fullStr The Development of Foveolar-type Gastric Adenocarcinoma during Maintenance Therapy of Vonoprazan for Reflux Esophagitis
title_full_unstemmed The Development of Foveolar-type Gastric Adenocarcinoma during Maintenance Therapy of Vonoprazan for Reflux Esophagitis
title_short The Development of Foveolar-type Gastric Adenocarcinoma during Maintenance Therapy of Vonoprazan for Reflux Esophagitis
title_sort development of foveolar-type gastric adenocarcinoma during maintenance therapy of vonoprazan for reflux esophagitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925268/
https://www.ncbi.nlm.nih.gov/pubmed/32863366
http://dx.doi.org/10.2169/internalmedicine.5431-20
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