Drug-induced Hypersensitivity Syndrome by EGFR-TKI in a Patient with Lung Cancer

An 83-years-old woman diagnosed with advanced Epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma was administered afatinib as a first-line treatment. On Day 17, the patient presented with grade 3 diarrhea and a blood test analysis showed an increased inflammatory response. Afatinib t...

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Detalles Bibliográficos
Autores principales: Oyama, Baku, Morikawa, Kei, Sakaguchi, Tadashi, Tsunoda, Akihito, Kida, Hirotaka, Inoue, Takeo, Mineshita, Masamichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925278/
https://www.ncbi.nlm.nih.gov/pubmed/33518612
http://dx.doi.org/10.2169/internalmedicine.4237-19
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author Oyama, Baku
Morikawa, Kei
Sakaguchi, Tadashi
Tsunoda, Akihito
Kida, Hirotaka
Inoue, Takeo
Mineshita, Masamichi
author_facet Oyama, Baku
Morikawa, Kei
Sakaguchi, Tadashi
Tsunoda, Akihito
Kida, Hirotaka
Inoue, Takeo
Mineshita, Masamichi
author_sort Oyama, Baku
collection PubMed
description An 83-years-old woman diagnosed with advanced Epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma was administered afatinib as a first-line treatment. On Day 17, the patient presented with grade 3 diarrhea and a blood test analysis showed an increased inflammatory response. Afatinib treatment was discontinued on the same day. On Day 26, the patient displayed blepharedema and multiple irregular erythema covering her entire body. Drug-induced hypersensitivity syndrome (DIHS) was suspected, and the systemic administration of 30 mg/day prednisolone was administered. The symptoms subsided thereafter. A blood test analysis 3 weeks after onset revealed a reactivation of Human herpesvirus 6 (HHV-6) and a diagnosis of DIHS due to afatinib therapy was confirmed.
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spelling pubmed-79252782021-03-10 Drug-induced Hypersensitivity Syndrome by EGFR-TKI in a Patient with Lung Cancer Oyama, Baku Morikawa, Kei Sakaguchi, Tadashi Tsunoda, Akihito Kida, Hirotaka Inoue, Takeo Mineshita, Masamichi Intern Med Case Report An 83-years-old woman diagnosed with advanced Epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma was administered afatinib as a first-line treatment. On Day 17, the patient presented with grade 3 diarrhea and a blood test analysis showed an increased inflammatory response. Afatinib treatment was discontinued on the same day. On Day 26, the patient displayed blepharedema and multiple irregular erythema covering her entire body. Drug-induced hypersensitivity syndrome (DIHS) was suspected, and the systemic administration of 30 mg/day prednisolone was administered. The symptoms subsided thereafter. A blood test analysis 3 weeks after onset revealed a reactivation of Human herpesvirus 6 (HHV-6) and a diagnosis of DIHS due to afatinib therapy was confirmed. The Japanese Society of Internal Medicine 2021-02-01 2021-02-01 /pmc/articles/PMC7925278/ /pubmed/33518612 http://dx.doi.org/10.2169/internalmedicine.4237-19 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Oyama, Baku
Morikawa, Kei
Sakaguchi, Tadashi
Tsunoda, Akihito
Kida, Hirotaka
Inoue, Takeo
Mineshita, Masamichi
Drug-induced Hypersensitivity Syndrome by EGFR-TKI in a Patient with Lung Cancer
title Drug-induced Hypersensitivity Syndrome by EGFR-TKI in a Patient with Lung Cancer
title_full Drug-induced Hypersensitivity Syndrome by EGFR-TKI in a Patient with Lung Cancer
title_fullStr Drug-induced Hypersensitivity Syndrome by EGFR-TKI in a Patient with Lung Cancer
title_full_unstemmed Drug-induced Hypersensitivity Syndrome by EGFR-TKI in a Patient with Lung Cancer
title_short Drug-induced Hypersensitivity Syndrome by EGFR-TKI in a Patient with Lung Cancer
title_sort drug-induced hypersensitivity syndrome by egfr-tki in a patient with lung cancer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925278/
https://www.ncbi.nlm.nih.gov/pubmed/33518612
http://dx.doi.org/10.2169/internalmedicine.4237-19
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