Multiple Malignant Lymphomas of the Bile Duct Developing after Spontaneous Regression of an Autoimmune Pancreatitis-like Mass

We herein report a 67-year-old woman with malignant lymphomas of the bile duct that developed after regression of a pancreatic head mass. Computed tomography suggested the mass was pancreatic head cancer. Endoscopic ultrasonography showed a low-echoic mass with hyperechoic strands resembling autoimm...

Descripción completa

Detalles Bibliográficos
Autores principales: Ohtsubo, Koushiro, Yamashita, Kaname, Yanagimura, Naohiro, Suzuki, Chiaki, Tanimoto, Azusa, Nishiyama, Akihiro, Takeuchi, Shinji, Iwaki, Noriko, Kawano, Mitsuhiro, Izumozaki, Akira, Inoue, Dai, Gabata, Toshifumi, Ikeda, Hiroko, Watanabe, Michio, Yano, Seiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925286/
https://www.ncbi.nlm.nih.gov/pubmed/32863365
http://dx.doi.org/10.2169/internalmedicine.5429-20
_version_ 1783659248826187776
author Ohtsubo, Koushiro
Yamashita, Kaname
Yanagimura, Naohiro
Suzuki, Chiaki
Tanimoto, Azusa
Nishiyama, Akihiro
Takeuchi, Shinji
Iwaki, Noriko
Kawano, Mitsuhiro
Izumozaki, Akira
Inoue, Dai
Gabata, Toshifumi
Ikeda, Hiroko
Watanabe, Michio
Yano, Seiji
author_facet Ohtsubo, Koushiro
Yamashita, Kaname
Yanagimura, Naohiro
Suzuki, Chiaki
Tanimoto, Azusa
Nishiyama, Akihiro
Takeuchi, Shinji
Iwaki, Noriko
Kawano, Mitsuhiro
Izumozaki, Akira
Inoue, Dai
Gabata, Toshifumi
Ikeda, Hiroko
Watanabe, Michio
Yano, Seiji
author_sort Ohtsubo, Koushiro
collection PubMed
description We herein report a 67-year-old woman with malignant lymphomas of the bile duct that developed after regression of a pancreatic head mass. Computed tomography suggested the mass was pancreatic head cancer. Endoscopic ultrasonography showed a low-echoic mass with hyperechoic strands resembling autoimmune pancreatitis. Her serum IgG4 concentration was elevated to 674 mg/dL. After the pancreatic head mass spontaneously diminished, three masses were detected in the common bile duct. A biopsy of the major papilla revealed high-grade B-cell lymphoma with MYC, BCL2 and/or BCL6 rearrangement. Systemic chemotherapy with rituximab plus etoposide, prednisolone, vincristine, cyclophosphamide and doxorubicin resulted in complete remission.
format Online
Article
Text
id pubmed-7925286
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-79252862021-03-10 Multiple Malignant Lymphomas of the Bile Duct Developing after Spontaneous Regression of an Autoimmune Pancreatitis-like Mass Ohtsubo, Koushiro Yamashita, Kaname Yanagimura, Naohiro Suzuki, Chiaki Tanimoto, Azusa Nishiyama, Akihiro Takeuchi, Shinji Iwaki, Noriko Kawano, Mitsuhiro Izumozaki, Akira Inoue, Dai Gabata, Toshifumi Ikeda, Hiroko Watanabe, Michio Yano, Seiji Intern Med Case Report We herein report a 67-year-old woman with malignant lymphomas of the bile duct that developed after regression of a pancreatic head mass. Computed tomography suggested the mass was pancreatic head cancer. Endoscopic ultrasonography showed a low-echoic mass with hyperechoic strands resembling autoimmune pancreatitis. Her serum IgG4 concentration was elevated to 674 mg/dL. After the pancreatic head mass spontaneously diminished, three masses were detected in the common bile duct. A biopsy of the major papilla revealed high-grade B-cell lymphoma with MYC, BCL2 and/or BCL6 rearrangement. Systemic chemotherapy with rituximab plus etoposide, prednisolone, vincristine, cyclophosphamide and doxorubicin resulted in complete remission. The Japanese Society of Internal Medicine 2020-08-29 2021-02-01 /pmc/articles/PMC7925286/ /pubmed/32863365 http://dx.doi.org/10.2169/internalmedicine.5429-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ohtsubo, Koushiro
Yamashita, Kaname
Yanagimura, Naohiro
Suzuki, Chiaki
Tanimoto, Azusa
Nishiyama, Akihiro
Takeuchi, Shinji
Iwaki, Noriko
Kawano, Mitsuhiro
Izumozaki, Akira
Inoue, Dai
Gabata, Toshifumi
Ikeda, Hiroko
Watanabe, Michio
Yano, Seiji
Multiple Malignant Lymphomas of the Bile Duct Developing after Spontaneous Regression of an Autoimmune Pancreatitis-like Mass
title Multiple Malignant Lymphomas of the Bile Duct Developing after Spontaneous Regression of an Autoimmune Pancreatitis-like Mass
title_full Multiple Malignant Lymphomas of the Bile Duct Developing after Spontaneous Regression of an Autoimmune Pancreatitis-like Mass
title_fullStr Multiple Malignant Lymphomas of the Bile Duct Developing after Spontaneous Regression of an Autoimmune Pancreatitis-like Mass
title_full_unstemmed Multiple Malignant Lymphomas of the Bile Duct Developing after Spontaneous Regression of an Autoimmune Pancreatitis-like Mass
title_short Multiple Malignant Lymphomas of the Bile Duct Developing after Spontaneous Regression of an Autoimmune Pancreatitis-like Mass
title_sort multiple malignant lymphomas of the bile duct developing after spontaneous regression of an autoimmune pancreatitis-like mass
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925286/
https://www.ncbi.nlm.nih.gov/pubmed/32863365
http://dx.doi.org/10.2169/internalmedicine.5429-20
work_keys_str_mv AT ohtsubokoushiro multiplemalignantlymphomasofthebileductdevelopingafterspontaneousregressionofanautoimmunepancreatitislikemass
AT yamashitakaname multiplemalignantlymphomasofthebileductdevelopingafterspontaneousregressionofanautoimmunepancreatitislikemass
AT yanagimuranaohiro multiplemalignantlymphomasofthebileductdevelopingafterspontaneousregressionofanautoimmunepancreatitislikemass
AT suzukichiaki multiplemalignantlymphomasofthebileductdevelopingafterspontaneousregressionofanautoimmunepancreatitislikemass
AT tanimotoazusa multiplemalignantlymphomasofthebileductdevelopingafterspontaneousregressionofanautoimmunepancreatitislikemass
AT nishiyamaakihiro multiplemalignantlymphomasofthebileductdevelopingafterspontaneousregressionofanautoimmunepancreatitislikemass
AT takeuchishinji multiplemalignantlymphomasofthebileductdevelopingafterspontaneousregressionofanautoimmunepancreatitislikemass
AT iwakinoriko multiplemalignantlymphomasofthebileductdevelopingafterspontaneousregressionofanautoimmunepancreatitislikemass
AT kawanomitsuhiro multiplemalignantlymphomasofthebileductdevelopingafterspontaneousregressionofanautoimmunepancreatitislikemass
AT izumozakiakira multiplemalignantlymphomasofthebileductdevelopingafterspontaneousregressionofanautoimmunepancreatitislikemass
AT inouedai multiplemalignantlymphomasofthebileductdevelopingafterspontaneousregressionofanautoimmunepancreatitislikemass
AT gabatatoshifumi multiplemalignantlymphomasofthebileductdevelopingafterspontaneousregressionofanautoimmunepancreatitislikemass
AT ikedahiroko multiplemalignantlymphomasofthebileductdevelopingafterspontaneousregressionofanautoimmunepancreatitislikemass
AT watanabemichio multiplemalignantlymphomasofthebileductdevelopingafterspontaneousregressionofanautoimmunepancreatitislikemass
AT yanoseiji multiplemalignantlymphomasofthebileductdevelopingafterspontaneousregressionofanautoimmunepancreatitislikemass

Ejemplares similares