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YKL-40 Is Associated With Ultrasound-Determined Carotid Atherosclerotic Plaque Instability
Background and Aims: YKL-40, an inflammatory biomarker, has been reported to be involved in the process and progression of atherosclerosis. Several studies have investigated the association between YKL-40 and plaque and suggested YKL-40 might be a potential biomarker for plaque instability. This stu...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925412/ https://www.ncbi.nlm.nih.gov/pubmed/33679587 http://dx.doi.org/10.3389/fneur.2021.622869 |
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author | Wang, Yu Li, Bohong Jiang, Yong Zhang, Runhua Meng, Xia Zhao, Xingquan Wang, Yongjun Zhao, Xihai Liu, Gaifen |
author_facet | Wang, Yu Li, Bohong Jiang, Yong Zhang, Runhua Meng, Xia Zhao, Xingquan Wang, Yongjun Zhao, Xihai Liu, Gaifen |
author_sort | Wang, Yu |
collection | PubMed |
description | Background and Aims: YKL-40, an inflammatory biomarker, has been reported to be involved in the process and progression of atherosclerosis. Several studies have investigated the association between YKL-40 and plaque and suggested YKL-40 might be a potential biomarker for plaque instability. This study aimed to investigate the association between YKL-40 and carotid plaque instability. Methods: Based on a community-based study in Beijing from February 2014 to May 2016, 1,132 participants with carotid plaques were enrolled in this study. Data on demographics and medical history were collected through face-to-face interviews, and fasting blood samples were collected and stored. We used ultrasound to evaluate the presence of carotid plaque and its instability. The level of YKL-40 was measured by enzyme-linked immunosorbent assay (ELISA). Multivariate logistic regression analysis was performed to investigate the association between YKL-40 level and carotid atherosclerotic plaque instability. Results: The mean age of the 1,132 participants was 58.0 (52.0–64.0) years, and 560 (49.5%) were male. Unstable plaques were detected in 855 (75.53%) participants. YKL-40 level was classified into four groups according to its quartile: quartile 1: <25.47 ng/mL, quartile 2: 25.47–39.53 ng/mL, quartile 3: 39.53–70.55 ng/mL, quartile 4: ≥70.55 ng/mL. After adjusting for age, sex, smoking, alcohol drinking, medical history, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, homocysteine, high-sensitivity C-reactive protein, and plaque thickness, the top quartiles of YKL-40 level were significantly associated with unstable plaque (quartile 3: OR 2.10, 95% CI 1.29–3.40; quartile 4: OR 1.70, 95% CI 1.04–2.80). Conclusion: This study found that YKL-40 was associated with carotid plaque instability determined by ultrasound. Individuals with high YKL-40 may have a higher risk of unstable carotid plaque. |
format | Online Article Text |
id | pubmed-7925412 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79254122021-03-04 YKL-40 Is Associated With Ultrasound-Determined Carotid Atherosclerotic Plaque Instability Wang, Yu Li, Bohong Jiang, Yong Zhang, Runhua Meng, Xia Zhao, Xingquan Wang, Yongjun Zhao, Xihai Liu, Gaifen Front Neurol Neurology Background and Aims: YKL-40, an inflammatory biomarker, has been reported to be involved in the process and progression of atherosclerosis. Several studies have investigated the association between YKL-40 and plaque and suggested YKL-40 might be a potential biomarker for plaque instability. This study aimed to investigate the association between YKL-40 and carotid plaque instability. Methods: Based on a community-based study in Beijing from February 2014 to May 2016, 1,132 participants with carotid plaques were enrolled in this study. Data on demographics and medical history were collected through face-to-face interviews, and fasting blood samples were collected and stored. We used ultrasound to evaluate the presence of carotid plaque and its instability. The level of YKL-40 was measured by enzyme-linked immunosorbent assay (ELISA). Multivariate logistic regression analysis was performed to investigate the association between YKL-40 level and carotid atherosclerotic plaque instability. Results: The mean age of the 1,132 participants was 58.0 (52.0–64.0) years, and 560 (49.5%) were male. Unstable plaques were detected in 855 (75.53%) participants. YKL-40 level was classified into four groups according to its quartile: quartile 1: <25.47 ng/mL, quartile 2: 25.47–39.53 ng/mL, quartile 3: 39.53–70.55 ng/mL, quartile 4: ≥70.55 ng/mL. After adjusting for age, sex, smoking, alcohol drinking, medical history, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, homocysteine, high-sensitivity C-reactive protein, and plaque thickness, the top quartiles of YKL-40 level were significantly associated with unstable plaque (quartile 3: OR 2.10, 95% CI 1.29–3.40; quartile 4: OR 1.70, 95% CI 1.04–2.80). Conclusion: This study found that YKL-40 was associated with carotid plaque instability determined by ultrasound. Individuals with high YKL-40 may have a higher risk of unstable carotid plaque. Frontiers Media S.A. 2021-02-17 /pmc/articles/PMC7925412/ /pubmed/33679587 http://dx.doi.org/10.3389/fneur.2021.622869 Text en Copyright © 2021 Wang, Li, Jiang, Zhang, Meng, Zhao, Wang, Zhao and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Wang, Yu Li, Bohong Jiang, Yong Zhang, Runhua Meng, Xia Zhao, Xingquan Wang, Yongjun Zhao, Xihai Liu, Gaifen YKL-40 Is Associated With Ultrasound-Determined Carotid Atherosclerotic Plaque Instability |
title | YKL-40 Is Associated With Ultrasound-Determined Carotid Atherosclerotic Plaque Instability |
title_full | YKL-40 Is Associated With Ultrasound-Determined Carotid Atherosclerotic Plaque Instability |
title_fullStr | YKL-40 Is Associated With Ultrasound-Determined Carotid Atherosclerotic Plaque Instability |
title_full_unstemmed | YKL-40 Is Associated With Ultrasound-Determined Carotid Atherosclerotic Plaque Instability |
title_short | YKL-40 Is Associated With Ultrasound-Determined Carotid Atherosclerotic Plaque Instability |
title_sort | ykl-40 is associated with ultrasound-determined carotid atherosclerotic plaque instability |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925412/ https://www.ncbi.nlm.nih.gov/pubmed/33679587 http://dx.doi.org/10.3389/fneur.2021.622869 |
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