Insights on Droplet Digital PCR–Based Cellular Kinetics and Biodistribution Assay Support for CAR-T Cell Therapy

Characterizing in vivo cellular kinetics and biodistribution of chimeric antigen receptor T (CAR-T) cells is critical for toxicity assessment, nonclinical and clinical efficacy studies. To date, the standardized assay to characterize CAR-T cell distribution, expansion, contraction, and persistence p...

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Detalles Bibliográficos
Autores principales: Sugimoto, Hiroshi, Chen, Susan, Minembe, Jean-Pierre, Chouitar, Johara, He, Xingyue, Wang, Haiqing, Fang, Xiaodong, Qian, Mark G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925486/
https://www.ncbi.nlm.nih.gov/pubmed/33655393
http://dx.doi.org/10.1208/s12248-021-00560-6

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