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Downregulation of XBP1 protects kidney against ischemia-reperfusion injury via suppressing HRD1-mediated NRF2 ubiquitylation

Ischemia-reperfusion (IR) injury to the renal epithelia is associated with endoplasmic reticulum stress (ERS) and mitochondria dysfunction, which lead to oxidative stress-induced acute kidney injury (AKI). X-box binding protein 1 (XBP1), an ERS response protein, could play a prominent role in IR-ind...

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Detalles Bibliográficos
Autores principales:	Zhang, Ji, Zhang, Jiasi, Ni, Haiqiang, Wang, Yanfeng, Katwal, Gaurav, Zhao, Yuanyuan, Sun, Kailun, Wang, Mengqin, Li, Qingwen, Chen, Gen, Miao, Yun, Gong, Nianqiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925512/ https://www.ncbi.nlm.nih.gov/pubmed/33654072 http://dx.doi.org/10.1038/s41420-021-00425-z

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