Programmable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins

Many genetic diseases are caused by single-nucleotide polymorphisms. Base editors can correct these mutations at single-nucleotide resolution, but until recently, only allowed for transition edits, addressing four out of twelve possible DNA base substitutions. Here, we develop a class of C:G to G:C...

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Detalles Bibliográficos
Autores principales: Chen, Liwei, Park, Jung Eun, Paa, Peter, Rajakumar, Priscilla D., Prekop, Hong-Ting, Chew, Yi Ting, Manivannan, Swathi N., Chew, Wei Leong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925527/
https://www.ncbi.nlm.nih.gov/pubmed/33654077
http://dx.doi.org/10.1038/s41467-021-21559-9

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