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Analysis of segmentation ontology reveals the similarities and differences in connectivity onto L2/3 neurons in mouse V1

Quantitatively comparing brain-wide connectivity of different types of neuron is of vital importance in understanding the function of the mammalian cortex. Here we have designed an analytical approach to examine and compare datasets from hierarchical segmentation ontologies, and applied it to long-r...

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Autores principales: Brown, Alexander P. Y., Cossell, Lee, Strom, Molly, Tyson, Adam L., Vélez-Fort, Mateo, Margrie, Troy W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925549/
https://www.ncbi.nlm.nih.gov/pubmed/33654118
http://dx.doi.org/10.1038/s41598-021-82353-7
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author Brown, Alexander P. Y.
Cossell, Lee
Strom, Molly
Tyson, Adam L.
Vélez-Fort, Mateo
Margrie, Troy W.
author_facet Brown, Alexander P. Y.
Cossell, Lee
Strom, Molly
Tyson, Adam L.
Vélez-Fort, Mateo
Margrie, Troy W.
author_sort Brown, Alexander P. Y.
collection PubMed
description Quantitatively comparing brain-wide connectivity of different types of neuron is of vital importance in understanding the function of the mammalian cortex. Here we have designed an analytical approach to examine and compare datasets from hierarchical segmentation ontologies, and applied it to long-range presynaptic connectivity onto excitatory and inhibitory neurons, mainly located in layer 2/3 (L2/3), of mouse primary visual cortex (V1). We find that the origins of long-range connections onto these two general cell classes—as well as their proportions—are quite similar, in contrast to the inputs on to a cell type in L6. These anatomical data suggest that distal inputs received by the general excitatory and inhibitory classes of neuron in L2/3 overlap considerably.
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spelling pubmed-79255492021-03-04 Analysis of segmentation ontology reveals the similarities and differences in connectivity onto L2/3 neurons in mouse V1 Brown, Alexander P. Y. Cossell, Lee Strom, Molly Tyson, Adam L. Vélez-Fort, Mateo Margrie, Troy W. Sci Rep Article Quantitatively comparing brain-wide connectivity of different types of neuron is of vital importance in understanding the function of the mammalian cortex. Here we have designed an analytical approach to examine and compare datasets from hierarchical segmentation ontologies, and applied it to long-range presynaptic connectivity onto excitatory and inhibitory neurons, mainly located in layer 2/3 (L2/3), of mouse primary visual cortex (V1). We find that the origins of long-range connections onto these two general cell classes—as well as their proportions—are quite similar, in contrast to the inputs on to a cell type in L6. These anatomical data suggest that distal inputs received by the general excitatory and inhibitory classes of neuron in L2/3 overlap considerably. Nature Publishing Group UK 2021-03-02 /pmc/articles/PMC7925549/ /pubmed/33654118 http://dx.doi.org/10.1038/s41598-021-82353-7 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Brown, Alexander P. Y.
Cossell, Lee
Strom, Molly
Tyson, Adam L.
Vélez-Fort, Mateo
Margrie, Troy W.
Analysis of segmentation ontology reveals the similarities and differences in connectivity onto L2/3 neurons in mouse V1
title Analysis of segmentation ontology reveals the similarities and differences in connectivity onto L2/3 neurons in mouse V1
title_full Analysis of segmentation ontology reveals the similarities and differences in connectivity onto L2/3 neurons in mouse V1
title_fullStr Analysis of segmentation ontology reveals the similarities and differences in connectivity onto L2/3 neurons in mouse V1
title_full_unstemmed Analysis of segmentation ontology reveals the similarities and differences in connectivity onto L2/3 neurons in mouse V1
title_short Analysis of segmentation ontology reveals the similarities and differences in connectivity onto L2/3 neurons in mouse V1
title_sort analysis of segmentation ontology reveals the similarities and differences in connectivity onto l2/3 neurons in mouse v1
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925549/
https://www.ncbi.nlm.nih.gov/pubmed/33654118
http://dx.doi.org/10.1038/s41598-021-82353-7
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