Cargando…

Compilation of longitudinal microbiota data and hospitalome from hematopoietic cell transplantation patients

The impact of the gut microbiota in human health is affected by several factors including its composition, drug administrations, therapeutic interventions and underlying diseases. Unfortunately, many human microbiota datasets available publicly were collected to study the impact of single variables,...

Descripción completa

Detalles Bibliográficos
Autores principales: Liao, Chen, Taylor, Bradford P., Ceccarani, Camilla, Fontana, Emily, Amoretti, Luigi A., Wright, Roberta J., Gomes, Antonio L. C., Peled, Jonathan U., Taur, Ying, Perales, Miguel-Angel, van den Brink, Marcel R. M., Littmann, Eric, Pamer, Eric G., Schluter, Jonas, Xavier, Joao B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925583/
https://www.ncbi.nlm.nih.gov/pubmed/33654104
http://dx.doi.org/10.1038/s41597-021-00860-8
_version_ 1783659300190683136
author Liao, Chen
Taylor, Bradford P.
Ceccarani, Camilla
Fontana, Emily
Amoretti, Luigi A.
Wright, Roberta J.
Gomes, Antonio L. C.
Peled, Jonathan U.
Taur, Ying
Perales, Miguel-Angel
van den Brink, Marcel R. M.
Littmann, Eric
Pamer, Eric G.
Schluter, Jonas
Xavier, Joao B.
author_facet Liao, Chen
Taylor, Bradford P.
Ceccarani, Camilla
Fontana, Emily
Amoretti, Luigi A.
Wright, Roberta J.
Gomes, Antonio L. C.
Peled, Jonathan U.
Taur, Ying
Perales, Miguel-Angel
van den Brink, Marcel R. M.
Littmann, Eric
Pamer, Eric G.
Schluter, Jonas
Xavier, Joao B.
author_sort Liao, Chen
collection PubMed
description The impact of the gut microbiota in human health is affected by several factors including its composition, drug administrations, therapeutic interventions and underlying diseases. Unfortunately, many human microbiota datasets available publicly were collected to study the impact of single variables, and typically consist of outpatients in cross-sectional studies, have small sample numbers and/or lack metadata to account for confounders. These limitations can complicate reusing the data for questions outside their original focus. Here, we provide comprehensive longitudinal patient dataset that overcomes those limitations: a collection of fecal microbiota compositions (>10,000 microbiota samples from >1,000 patients) and a rich description of the “hospitalome” experienced by the hosts, i.e., their drug exposures and other metadata from patients with cancer, hospitalized to receive allogeneic hematopoietic cell transplantation (allo-HCT) at a large cancer center in the United States. We present five examples of how to apply these data to address clinical and scientific questions on host-associated microbial communities.
format Online
Article
Text
id pubmed-7925583
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-79255832021-03-19 Compilation of longitudinal microbiota data and hospitalome from hematopoietic cell transplantation patients Liao, Chen Taylor, Bradford P. Ceccarani, Camilla Fontana, Emily Amoretti, Luigi A. Wright, Roberta J. Gomes, Antonio L. C. Peled, Jonathan U. Taur, Ying Perales, Miguel-Angel van den Brink, Marcel R. M. Littmann, Eric Pamer, Eric G. Schluter, Jonas Xavier, Joao B. Sci Data Data Descriptor The impact of the gut microbiota in human health is affected by several factors including its composition, drug administrations, therapeutic interventions and underlying diseases. Unfortunately, many human microbiota datasets available publicly were collected to study the impact of single variables, and typically consist of outpatients in cross-sectional studies, have small sample numbers and/or lack metadata to account for confounders. These limitations can complicate reusing the data for questions outside their original focus. Here, we provide comprehensive longitudinal patient dataset that overcomes those limitations: a collection of fecal microbiota compositions (>10,000 microbiota samples from >1,000 patients) and a rich description of the “hospitalome” experienced by the hosts, i.e., their drug exposures and other metadata from patients with cancer, hospitalized to receive allogeneic hematopoietic cell transplantation (allo-HCT) at a large cancer center in the United States. We present five examples of how to apply these data to address clinical and scientific questions on host-associated microbial communities. Nature Publishing Group UK 2021-03-02 /pmc/articles/PMC7925583/ /pubmed/33654104 http://dx.doi.org/10.1038/s41597-021-00860-8 Text en © The Author(s) 2021, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) applies to the metadata files associated with this article.
spellingShingle Data Descriptor
Liao, Chen
Taylor, Bradford P.
Ceccarani, Camilla
Fontana, Emily
Amoretti, Luigi A.
Wright, Roberta J.
Gomes, Antonio L. C.
Peled, Jonathan U.
Taur, Ying
Perales, Miguel-Angel
van den Brink, Marcel R. M.
Littmann, Eric
Pamer, Eric G.
Schluter, Jonas
Xavier, Joao B.
Compilation of longitudinal microbiota data and hospitalome from hematopoietic cell transplantation patients
title Compilation of longitudinal microbiota data and hospitalome from hematopoietic cell transplantation patients
title_full Compilation of longitudinal microbiota data and hospitalome from hematopoietic cell transplantation patients
title_fullStr Compilation of longitudinal microbiota data and hospitalome from hematopoietic cell transplantation patients
title_full_unstemmed Compilation of longitudinal microbiota data and hospitalome from hematopoietic cell transplantation patients
title_short Compilation of longitudinal microbiota data and hospitalome from hematopoietic cell transplantation patients
title_sort compilation of longitudinal microbiota data and hospitalome from hematopoietic cell transplantation patients
topic Data Descriptor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925583/
https://www.ncbi.nlm.nih.gov/pubmed/33654104
http://dx.doi.org/10.1038/s41597-021-00860-8
work_keys_str_mv AT liaochen compilationoflongitudinalmicrobiotadataandhospitalomefromhematopoieticcelltransplantationpatients
AT taylorbradfordp compilationoflongitudinalmicrobiotadataandhospitalomefromhematopoieticcelltransplantationpatients
AT ceccaranicamilla compilationoflongitudinalmicrobiotadataandhospitalomefromhematopoieticcelltransplantationpatients
AT fontanaemily compilationoflongitudinalmicrobiotadataandhospitalomefromhematopoieticcelltransplantationpatients
AT amorettiluigia compilationoflongitudinalmicrobiotadataandhospitalomefromhematopoieticcelltransplantationpatients
AT wrightrobertaj compilationoflongitudinalmicrobiotadataandhospitalomefromhematopoieticcelltransplantationpatients
AT gomesantoniolc compilationoflongitudinalmicrobiotadataandhospitalomefromhematopoieticcelltransplantationpatients
AT peledjonathanu compilationoflongitudinalmicrobiotadataandhospitalomefromhematopoieticcelltransplantationpatients
AT taurying compilationoflongitudinalmicrobiotadataandhospitalomefromhematopoieticcelltransplantationpatients
AT peralesmiguelangel compilationoflongitudinalmicrobiotadataandhospitalomefromhematopoieticcelltransplantationpatients
AT vandenbrinkmarcelrm compilationoflongitudinalmicrobiotadataandhospitalomefromhematopoieticcelltransplantationpatients
AT littmanneric compilationoflongitudinalmicrobiotadataandhospitalomefromhematopoieticcelltransplantationpatients
AT pamerericg compilationoflongitudinalmicrobiotadataandhospitalomefromhematopoieticcelltransplantationpatients
AT schluterjonas compilationoflongitudinalmicrobiotadataandhospitalomefromhematopoieticcelltransplantationpatients
AT xavierjoaob compilationoflongitudinalmicrobiotadataandhospitalomefromhematopoieticcelltransplantationpatients