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Prognostic value of cardiac biomarkers in COVID-19 infection

Multiple Biomarkers have recently been shown to be elevated in COVID-19, a respiratory infection with multi-organ dysfunction; however, information regarding the prognostic value of cardiac biomarkers as it relates to disease severity and cardiac injury are inconsistent. The goal of this meta-analys...

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Autores principales: Sheth, Aakash, Modi, Malak, Dawson, Desiree’, Dominic, Paari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925599/
https://www.ncbi.nlm.nih.gov/pubmed/33654230
http://dx.doi.org/10.1038/s41598-021-84643-6
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author Sheth, Aakash
Modi, Malak
Dawson, Desiree’
Dominic, Paari
author_facet Sheth, Aakash
Modi, Malak
Dawson, Desiree’
Dominic, Paari
author_sort Sheth, Aakash
collection PubMed
description Multiple Biomarkers have recently been shown to be elevated in COVID-19, a respiratory infection with multi-organ dysfunction; however, information regarding the prognostic value of cardiac biomarkers as it relates to disease severity and cardiac injury are inconsistent. The goal of this meta-analysis was to summarize the evidence regarding the prognostic relevance of cardiac biomarkers from data available in published reports. PubMed, Embase and Web of Science were searched from inception through April 2020 for studies comparing median values of cardiac biomarkers in critically ill versus non-critically ill COVID-19 patients, or patients who died versus those who survived. The weighted mean differences (WMD) and 95% confidence interval (CI) between the groups were calculated for each study and combined using a random effects meta-analysis model. The odds ratio (OR) for mortality based on cardiac injury was combined from studies reporting it. Troponin levels were significantly higher in COVID-19 patients who died or were critically ill versus those who were alive or not critically ill (WMD 0.57, 95% CI 0.43–0.70, p < 0.001). Additionally, BNP levels were also significantly higher in patients who died or were critically ill (WMD 0.45, 95% CI − 0.21–0.69, p < 0.001). Cardiac injury was independently associated with significantly increased odds of mortality (OR 6.641, 95% CI 1.26–35.1, p = 0.03). A significant difference in levels of D-dimer was seen in those who died or were critically ill. CK levels were only significantly higher in those who died versus those who were alive (WMD 0.79, 95% CI 0.25–1.33, p = 0.004). Cardiac biomarkers add prognostic value to the determination of the severity of COVID-19 and can predict mortality.
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spelling pubmed-79255992021-03-04 Prognostic value of cardiac biomarkers in COVID-19 infection Sheth, Aakash Modi, Malak Dawson, Desiree’ Dominic, Paari Sci Rep Article Multiple Biomarkers have recently been shown to be elevated in COVID-19, a respiratory infection with multi-organ dysfunction; however, information regarding the prognostic value of cardiac biomarkers as it relates to disease severity and cardiac injury are inconsistent. The goal of this meta-analysis was to summarize the evidence regarding the prognostic relevance of cardiac biomarkers from data available in published reports. PubMed, Embase and Web of Science were searched from inception through April 2020 for studies comparing median values of cardiac biomarkers in critically ill versus non-critically ill COVID-19 patients, or patients who died versus those who survived. The weighted mean differences (WMD) and 95% confidence interval (CI) between the groups were calculated for each study and combined using a random effects meta-analysis model. The odds ratio (OR) for mortality based on cardiac injury was combined from studies reporting it. Troponin levels were significantly higher in COVID-19 patients who died or were critically ill versus those who were alive or not critically ill (WMD 0.57, 95% CI 0.43–0.70, p < 0.001). Additionally, BNP levels were also significantly higher in patients who died or were critically ill (WMD 0.45, 95% CI − 0.21–0.69, p < 0.001). Cardiac injury was independently associated with significantly increased odds of mortality (OR 6.641, 95% CI 1.26–35.1, p = 0.03). A significant difference in levels of D-dimer was seen in those who died or were critically ill. CK levels were only significantly higher in those who died versus those who were alive (WMD 0.79, 95% CI 0.25–1.33, p = 0.004). Cardiac biomarkers add prognostic value to the determination of the severity of COVID-19 and can predict mortality. Nature Publishing Group UK 2021-03-02 /pmc/articles/PMC7925599/ /pubmed/33654230 http://dx.doi.org/10.1038/s41598-021-84643-6 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Sheth, Aakash
Modi, Malak
Dawson, Desiree’
Dominic, Paari
Prognostic value of cardiac biomarkers in COVID-19 infection
title Prognostic value of cardiac biomarkers in COVID-19 infection
title_full Prognostic value of cardiac biomarkers in COVID-19 infection
title_fullStr Prognostic value of cardiac biomarkers in COVID-19 infection
title_full_unstemmed Prognostic value of cardiac biomarkers in COVID-19 infection
title_short Prognostic value of cardiac biomarkers in COVID-19 infection
title_sort prognostic value of cardiac biomarkers in covid-19 infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925599/
https://www.ncbi.nlm.nih.gov/pubmed/33654230
http://dx.doi.org/10.1038/s41598-021-84643-6
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