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Geographical distribution and regional differences in 532 clinical isolates of rapidly growing mycobacterial species in Japan

Infectious diseases caused by nontuberculous mycobacteria (NTM) are increasingly becoming a major global problem. Additionally, Mycobacteroides abscessus subsp. abscessus (MAB) infections are refractory to macrolides. This study was conducted to investigate the epidemiology of rapidly growing mycoba...

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Autores principales: Kamada, Keisuke, Yoshida, Atsushi, Iguchi, Shigekazu, Arai, Yuko, Uzawa, Yutaka, Konno, Satoshi, Shimojima, Masahiro, Kikuchi, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925662/
https://www.ncbi.nlm.nih.gov/pubmed/33654194
http://dx.doi.org/10.1038/s41598-021-84537-7
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author Kamada, Keisuke
Yoshida, Atsushi
Iguchi, Shigekazu
Arai, Yuko
Uzawa, Yutaka
Konno, Satoshi
Shimojima, Masahiro
Kikuchi, Ken
author_facet Kamada, Keisuke
Yoshida, Atsushi
Iguchi, Shigekazu
Arai, Yuko
Uzawa, Yutaka
Konno, Satoshi
Shimojima, Masahiro
Kikuchi, Ken
author_sort Kamada, Keisuke
collection PubMed
description Infectious diseases caused by nontuberculous mycobacteria (NTM) are increasingly becoming a major global problem. Additionally, Mycobacteroides abscessus subsp. abscessus (MAB) infections are refractory to macrolides. This study was conducted to investigate the epidemiology of rapidly growing mycobacteria (RGM) species isolated from clinical specimens in Japan and assess differences in the regional distribution of lower respiratory specimens (LRS)- and non-lower respiratory specimens (NLRS)-derived species. 532 strains (427 LRS, 92 NLRS and 15 unknown specimens) were isolated in nine areas of Japan. We collected 418 specimens from Bio Medical Laboratories (BML), Inc., and 114 specimens from 45 hospitals in Japan. Their epidemiological differences were examined according to the specimen type, region, and climate. Fifteen species were identified. The proportion of M. abscessus group (MAG) strains was significantly lower in NLRS than in LRS (35.9% vs. 68.4%). The proportion of MAG strains was higher in northern Japan than in other regions (83.7% vs. 60.5%). Variations in strain abundance among RGM species was evident in regions with a mean annual temperature below 15 °C. We conclude that the proportions of MAG strains differed between NLRS and LRS in Japan. In addition, the mean annual temperature likely influenced the distribution of RGM species.
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spelling pubmed-79256622021-03-04 Geographical distribution and regional differences in 532 clinical isolates of rapidly growing mycobacterial species in Japan Kamada, Keisuke Yoshida, Atsushi Iguchi, Shigekazu Arai, Yuko Uzawa, Yutaka Konno, Satoshi Shimojima, Masahiro Kikuchi, Ken Sci Rep Article Infectious diseases caused by nontuberculous mycobacteria (NTM) are increasingly becoming a major global problem. Additionally, Mycobacteroides abscessus subsp. abscessus (MAB) infections are refractory to macrolides. This study was conducted to investigate the epidemiology of rapidly growing mycobacteria (RGM) species isolated from clinical specimens in Japan and assess differences in the regional distribution of lower respiratory specimens (LRS)- and non-lower respiratory specimens (NLRS)-derived species. 532 strains (427 LRS, 92 NLRS and 15 unknown specimens) were isolated in nine areas of Japan. We collected 418 specimens from Bio Medical Laboratories (BML), Inc., and 114 specimens from 45 hospitals in Japan. Their epidemiological differences were examined according to the specimen type, region, and climate. Fifteen species were identified. The proportion of M. abscessus group (MAG) strains was significantly lower in NLRS than in LRS (35.9% vs. 68.4%). The proportion of MAG strains was higher in northern Japan than in other regions (83.7% vs. 60.5%). Variations in strain abundance among RGM species was evident in regions with a mean annual temperature below 15 °C. We conclude that the proportions of MAG strains differed between NLRS and LRS in Japan. In addition, the mean annual temperature likely influenced the distribution of RGM species. Nature Publishing Group UK 2021-03-02 /pmc/articles/PMC7925662/ /pubmed/33654194 http://dx.doi.org/10.1038/s41598-021-84537-7 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kamada, Keisuke
Yoshida, Atsushi
Iguchi, Shigekazu
Arai, Yuko
Uzawa, Yutaka
Konno, Satoshi
Shimojima, Masahiro
Kikuchi, Ken
Geographical distribution and regional differences in 532 clinical isolates of rapidly growing mycobacterial species in Japan
title Geographical distribution and regional differences in 532 clinical isolates of rapidly growing mycobacterial species in Japan
title_full Geographical distribution and regional differences in 532 clinical isolates of rapidly growing mycobacterial species in Japan
title_fullStr Geographical distribution and regional differences in 532 clinical isolates of rapidly growing mycobacterial species in Japan
title_full_unstemmed Geographical distribution and regional differences in 532 clinical isolates of rapidly growing mycobacterial species in Japan
title_short Geographical distribution and regional differences in 532 clinical isolates of rapidly growing mycobacterial species in Japan
title_sort geographical distribution and regional differences in 532 clinical isolates of rapidly growing mycobacterial species in japan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925662/
https://www.ncbi.nlm.nih.gov/pubmed/33654194
http://dx.doi.org/10.1038/s41598-021-84537-7
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