ChAdOx1-vectored Lassa fever vaccine elicits a robust cellular and humoral immune response and protects guinea pigs against lethal Lassa virus challenge

Lassa virus (LASV) infects hundreds of thousands of individuals each year, highlighting the need for the accelerated development of preventive, diagnostic, and therapeutic interventions. To date, no vaccine has been licensed for LASV. ChAdOx1-Lassa-GPC is a chimpanzee adenovirus-vectored vaccine enc...

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Detalles Bibliográficos
Autores principales: Fischer, Robert J., Purushotham, Jyothi N., van Doremalen, Neeltje, Sebastian, Sarah, Meade-White, Kimberly, Cordova, Kathleen, Letko, Michael, Jeremiah Matson, M., Feldmann, Friederike, Haddock, Elaine, LaCasse, Rachel, Saturday, Greg, Lambe, Teresa, Gilbert, Sarah C., Munster, Vincent J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925663/
https://www.ncbi.nlm.nih.gov/pubmed/33654106
http://dx.doi.org/10.1038/s41541-021-00291-x

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