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Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response

Cellular adaptation to hypoxia is a hallmark of cancer, but the relative contribution of hypoxia-inducible factors (HIFs) versus other oxygen sensors to tumorigenesis is unclear. We employ a multi-omics pipeline including measurements of nascent RNA to characterize transcriptional changes upon acute...

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Detalles Bibliográficos
Autores principales:	Andrysik, Zdenek, Bender, Heather, Galbraith, Matthew D., Espinosa, Joaquin M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925689/ https://www.ncbi.nlm.nih.gov/pubmed/33654095 http://dx.doi.org/10.1038/s41467-021-21687-2

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