Drug-Drug Interactions at Organic Cation Transporter 1

The interaction between drugs and various transporters is one of the decisive factors that affect the pharmacokinetics and pharmacodynamics of drugs. The organic cation transporter 1 (OCT1) is a member of the Solute Carrier 22A (SLC22A) family that plays a vital role in the membrane transport of org...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Shiwei, Zeng, Sujuan, Shu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925875/
https://www.ncbi.nlm.nih.gov/pubmed/33679412
http://dx.doi.org/10.3389/fphar.2021.628705
_version_ 1783659346523062272
author Zhou, Shiwei
Zeng, Sujuan
Shu, Yan
author_facet Zhou, Shiwei
Zeng, Sujuan
Shu, Yan
author_sort Zhou, Shiwei
collection PubMed
description The interaction between drugs and various transporters is one of the decisive factors that affect the pharmacokinetics and pharmacodynamics of drugs. The organic cation transporter 1 (OCT1) is a member of the Solute Carrier 22A (SLC22A) family that plays a vital role in the membrane transport of organic cations including endogenous substances and xenobiotics. This article mainly discusses the drug-drug interactions (DDIs) mediated by OCT1 and their clinical significance.
format Online
Article
Text
id pubmed-7925875
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-79258752021-03-04 Drug-Drug Interactions at Organic Cation Transporter 1 Zhou, Shiwei Zeng, Sujuan Shu, Yan Front Pharmacol Pharmacology The interaction between drugs and various transporters is one of the decisive factors that affect the pharmacokinetics and pharmacodynamics of drugs. The organic cation transporter 1 (OCT1) is a member of the Solute Carrier 22A (SLC22A) family that plays a vital role in the membrane transport of organic cations including endogenous substances and xenobiotics. This article mainly discusses the drug-drug interactions (DDIs) mediated by OCT1 and their clinical significance. Frontiers Media S.A. 2021-02-17 /pmc/articles/PMC7925875/ /pubmed/33679412 http://dx.doi.org/10.3389/fphar.2021.628705 Text en Copyright © 2021 Zhou, Zeng and Shu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Zhou, Shiwei
Zeng, Sujuan
Shu, Yan
Drug-Drug Interactions at Organic Cation Transporter 1
title Drug-Drug Interactions at Organic Cation Transporter 1
title_full Drug-Drug Interactions at Organic Cation Transporter 1
title_fullStr Drug-Drug Interactions at Organic Cation Transporter 1
title_full_unstemmed Drug-Drug Interactions at Organic Cation Transporter 1
title_short Drug-Drug Interactions at Organic Cation Transporter 1
title_sort drug-drug interactions at organic cation transporter 1
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925875/
https://www.ncbi.nlm.nih.gov/pubmed/33679412
http://dx.doi.org/10.3389/fphar.2021.628705
work_keys_str_mv AT zhoushiwei drugdruginteractionsatorganiccationtransporter1
AT zengsujuan drugdruginteractionsatorganiccationtransporter1
AT shuyan drugdruginteractionsatorganiccationtransporter1

Ejemplares similares