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Prevention of Chronic Rejection of Marginal Kidney Graft by Using a Hydrogen Gas-Containing Preservation Solution and Adequate Immunosuppression in a Miniature Pig Model

In clinical kidney transplantation, the marginal kidney donors are known to develop chronic allograft rejection more frequently than living kidney donors. In our previous study, we have reported that the hydrogen gas-containing organ preservation solution prevented the development of acute injuries...

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Autores principales: Nishi, Kotaro, Iwai, Satomi, Tajima, Kazuki, Okano, Shozo, Sano, Motoaki, Kobayashi, Eiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925892/
https://www.ncbi.nlm.nih.gov/pubmed/33679720
http://dx.doi.org/10.3389/fimmu.2020.626295
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author Nishi, Kotaro
Iwai, Satomi
Tajima, Kazuki
Okano, Shozo
Sano, Motoaki
Kobayashi, Eiji
author_facet Nishi, Kotaro
Iwai, Satomi
Tajima, Kazuki
Okano, Shozo
Sano, Motoaki
Kobayashi, Eiji
author_sort Nishi, Kotaro
collection PubMed
description In clinical kidney transplantation, the marginal kidney donors are known to develop chronic allograft rejection more frequently than living kidney donors. In our previous study, we have reported that the hydrogen gas-containing organ preservation solution prevented the development of acute injuries in the kidney of the donor after cardiac death by using preclinical miniature pig model. In the present study, we verified the impact of hydrogen gas treatment in transplantation with the optimal immunosuppressive protocol based on human clinical setting by using the miniature pig model. Marginal kidney processed by hydrogen gas-containing preservation solution has been engrafted for long-term (longer than 100 days). A few cases showed chronic rejection reaction; however, most were found to be free of chronic rejection such as graft tissue fibrosis or renal vasculitis. We concluded that marginal kidney graft from donor after cardiac death is an acceptable model for chronic rejection and that if the transplantation is carried out using a strict immunosuppressive protocol, chronic rejection may be alleviated even with the marginal kidney.
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spelling pubmed-79258922021-03-04 Prevention of Chronic Rejection of Marginal Kidney Graft by Using a Hydrogen Gas-Containing Preservation Solution and Adequate Immunosuppression in a Miniature Pig Model Nishi, Kotaro Iwai, Satomi Tajima, Kazuki Okano, Shozo Sano, Motoaki Kobayashi, Eiji Front Immunol Immunology In clinical kidney transplantation, the marginal kidney donors are known to develop chronic allograft rejection more frequently than living kidney donors. In our previous study, we have reported that the hydrogen gas-containing organ preservation solution prevented the development of acute injuries in the kidney of the donor after cardiac death by using preclinical miniature pig model. In the present study, we verified the impact of hydrogen gas treatment in transplantation with the optimal immunosuppressive protocol based on human clinical setting by using the miniature pig model. Marginal kidney processed by hydrogen gas-containing preservation solution has been engrafted for long-term (longer than 100 days). A few cases showed chronic rejection reaction; however, most were found to be free of chronic rejection such as graft tissue fibrosis or renal vasculitis. We concluded that marginal kidney graft from donor after cardiac death is an acceptable model for chronic rejection and that if the transplantation is carried out using a strict immunosuppressive protocol, chronic rejection may be alleviated even with the marginal kidney. Frontiers Media S.A. 2021-02-17 /pmc/articles/PMC7925892/ /pubmed/33679720 http://dx.doi.org/10.3389/fimmu.2020.626295 Text en Copyright © 2021 Nishi, Iwai, Tajima, Okano, Sano and Kobayashi http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Nishi, Kotaro
Iwai, Satomi
Tajima, Kazuki
Okano, Shozo
Sano, Motoaki
Kobayashi, Eiji
Prevention of Chronic Rejection of Marginal Kidney Graft by Using a Hydrogen Gas-Containing Preservation Solution and Adequate Immunosuppression in a Miniature Pig Model
title Prevention of Chronic Rejection of Marginal Kidney Graft by Using a Hydrogen Gas-Containing Preservation Solution and Adequate Immunosuppression in a Miniature Pig Model
title_full Prevention of Chronic Rejection of Marginal Kidney Graft by Using a Hydrogen Gas-Containing Preservation Solution and Adequate Immunosuppression in a Miniature Pig Model
title_fullStr Prevention of Chronic Rejection of Marginal Kidney Graft by Using a Hydrogen Gas-Containing Preservation Solution and Adequate Immunosuppression in a Miniature Pig Model
title_full_unstemmed Prevention of Chronic Rejection of Marginal Kidney Graft by Using a Hydrogen Gas-Containing Preservation Solution and Adequate Immunosuppression in a Miniature Pig Model
title_short Prevention of Chronic Rejection of Marginal Kidney Graft by Using a Hydrogen Gas-Containing Preservation Solution and Adequate Immunosuppression in a Miniature Pig Model
title_sort prevention of chronic rejection of marginal kidney graft by using a hydrogen gas-containing preservation solution and adequate immunosuppression in a miniature pig model
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925892/
https://www.ncbi.nlm.nih.gov/pubmed/33679720
http://dx.doi.org/10.3389/fimmu.2020.626295
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