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Locus Minoris Resistentiae: Two Cases of Malignant Metastasis and Review of Literature

Locus minoris resistentiae refers to a region of decreased resistance within the body. This occurs from changes to the microenvironment secondary to previous trauma and results in increased vulnerability. As a result, infection, inflammatory processes, and malignancy may localize to this area. In th...

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Detalles Bibliográficos
Autores principales: Farmand, Donya, Valdez, Michael C., Moosavi, Leila, Cobos, Everardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926049/
https://www.ncbi.nlm.nih.gov/pubmed/33629603
http://dx.doi.org/10.1177/2324709621997248
Descripción
Sumario:Locus minoris resistentiae refers to a region of decreased resistance within the body. This occurs from changes to the microenvironment secondary to previous trauma and results in increased vulnerability. As a result, infection, inflammatory processes, and malignancy may localize to this area. In this article, we describe 2 unique cases of malignancy, primary prostate carcinoma and serous carcinoma of the ovary, both of which disseminated to sites of prior trauma. We review the available literature, discuss proposed pathophysiology, and highlight the need for further investigations along with increased clinician awareness.