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Locus Minoris Resistentiae: Two Cases of Malignant Metastasis and Review of Literature

Locus minoris resistentiae refers to a region of decreased resistance within the body. This occurs from changes to the microenvironment secondary to previous trauma and results in increased vulnerability. As a result, infection, inflammatory processes, and malignancy may localize to this area. In th...

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Detalles Bibliográficos
Autores principales: Farmand, Donya, Valdez, Michael C., Moosavi, Leila, Cobos, Everardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926049/
https://www.ncbi.nlm.nih.gov/pubmed/33629603
http://dx.doi.org/10.1177/2324709621997248
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author Farmand, Donya
Valdez, Michael C.
Moosavi, Leila
Cobos, Everardo
author_facet Farmand, Donya
Valdez, Michael C.
Moosavi, Leila
Cobos, Everardo
author_sort Farmand, Donya
collection PubMed
description Locus minoris resistentiae refers to a region of decreased resistance within the body. This occurs from changes to the microenvironment secondary to previous trauma and results in increased vulnerability. As a result, infection, inflammatory processes, and malignancy may localize to this area. In this article, we describe 2 unique cases of malignancy, primary prostate carcinoma and serous carcinoma of the ovary, both of which disseminated to sites of prior trauma. We review the available literature, discuss proposed pathophysiology, and highlight the need for further investigations along with increased clinician awareness.
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spelling pubmed-79260492021-03-11 Locus Minoris Resistentiae: Two Cases of Malignant Metastasis and Review of Literature Farmand, Donya Valdez, Michael C. Moosavi, Leila Cobos, Everardo J Investig Med High Impact Case Rep Case Report Locus minoris resistentiae refers to a region of decreased resistance within the body. This occurs from changes to the microenvironment secondary to previous trauma and results in increased vulnerability. As a result, infection, inflammatory processes, and malignancy may localize to this area. In this article, we describe 2 unique cases of malignancy, primary prostate carcinoma and serous carcinoma of the ovary, both of which disseminated to sites of prior trauma. We review the available literature, discuss proposed pathophysiology, and highlight the need for further investigations along with increased clinician awareness. SAGE Publications 2021-02-25 /pmc/articles/PMC7926049/ /pubmed/33629603 http://dx.doi.org/10.1177/2324709621997248 Text en © 2021 American Federation for Medical Research https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Farmand, Donya
Valdez, Michael C.
Moosavi, Leila
Cobos, Everardo
Locus Minoris Resistentiae: Two Cases of Malignant Metastasis and Review of Literature
title Locus Minoris Resistentiae: Two Cases of Malignant Metastasis and Review of Literature
title_full Locus Minoris Resistentiae: Two Cases of Malignant Metastasis and Review of Literature
title_fullStr Locus Minoris Resistentiae: Two Cases of Malignant Metastasis and Review of Literature
title_full_unstemmed Locus Minoris Resistentiae: Two Cases of Malignant Metastasis and Review of Literature
title_short Locus Minoris Resistentiae: Two Cases of Malignant Metastasis and Review of Literature
title_sort locus minoris resistentiae: two cases of malignant metastasis and review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926049/
https://www.ncbi.nlm.nih.gov/pubmed/33629603
http://dx.doi.org/10.1177/2324709621997248
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