H4K20me1 and H3K27me3 are concurrently loaded onto the inactive X chromosome but dispensable for inducing gene silencing

During X chromosome inactivation (XCI), in female placental mammals, gene silencing is initiated by the Xist long non‐coding RNA. Xist accumulation at the X leads to enrichment of specific chromatin marks, including PRC2‐dependent H3K27me3 and SETD8‐dependent H4K20me1. However, the dynamics of this...

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Detalles Bibliográficos
Autores principales: Tjalsma, Sjoerd J D, Hori, Mayako, Sato, Yuko, Bousard, Aurelie, Ohi, Akito, Raposo, Ana Cláudia, Roensch, Julia, Le Saux, Agnes, Nogami, Jumpei, Maehara, Kazumitsu, Kujirai, Tomoya, Handa, Tetsuya, Bagés‐Arnal, Sandra, Ohkawa, Yasuyuki, Kurumizaka, Hitoshi, da Rocha, Simão Teixeira, Żylicz, Jan J, Kimura, Hiroshi, Heard, Edith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926250/
https://www.ncbi.nlm.nih.gov/pubmed/33605056
http://dx.doi.org/10.15252/embr.202051989

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