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Neuroprogression as an Illness Trajectory in Bipolar Disorder: A Selective Review of the Current Literature
Bipolar disorder (BD) is a chronic and disabling psychiatric condition that is linked to significant disability and psychosocial impairment. Although current neuropsychological, molecular, and neuroimaging evidence support the existence of neuroprogression and its effects on the course and outcome o...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926350/ https://www.ncbi.nlm.nih.gov/pubmed/33672401 http://dx.doi.org/10.3390/brainsci11020276 |
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author | Serafini, Gianluca Pardini, Matteo Monacelli, Fiammetta Orso, Beatrice Girtler, Nicola Brugnolo, Andrea Amore, Mario Nobili, Flavio |
author_facet | Serafini, Gianluca Pardini, Matteo Monacelli, Fiammetta Orso, Beatrice Girtler, Nicola Brugnolo, Andrea Amore, Mario Nobili, Flavio |
author_sort | Serafini, Gianluca |
collection | PubMed |
description | Bipolar disorder (BD) is a chronic and disabling psychiatric condition that is linked to significant disability and psychosocial impairment. Although current neuropsychological, molecular, and neuroimaging evidence support the existence of neuroprogression and its effects on the course and outcome of this condition, whether and to what extent neuroprogressive changes may impact the illness trajectory is still poorly understood. Thus, this selective review was aimed toward comprehensively and critically investigating the link between BD and neurodegeneration based on the currently available evidence. According to the most relevant findings of the present review, most of the existing neuropsychological, neuroimaging, and molecular evidence demonstrates the existence of neuroprogression, at least in a subgroup of BD patients. These studies mainly focused on the most relevant effects of neuroprogression on the course and outcome of BD. The main implications of this assumption are discussed in light of specific shortcomings/limitations, such as the inability to carry out a meta-analysis, the inclusion of studies with small sample sizes, retrospective study designs, and different longitudinal investigations at various time points. |
format | Online Article Text |
id | pubmed-7926350 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79263502021-03-04 Neuroprogression as an Illness Trajectory in Bipolar Disorder: A Selective Review of the Current Literature Serafini, Gianluca Pardini, Matteo Monacelli, Fiammetta Orso, Beatrice Girtler, Nicola Brugnolo, Andrea Amore, Mario Nobili, Flavio Brain Sci Review Bipolar disorder (BD) is a chronic and disabling psychiatric condition that is linked to significant disability and psychosocial impairment. Although current neuropsychological, molecular, and neuroimaging evidence support the existence of neuroprogression and its effects on the course and outcome of this condition, whether and to what extent neuroprogressive changes may impact the illness trajectory is still poorly understood. Thus, this selective review was aimed toward comprehensively and critically investigating the link between BD and neurodegeneration based on the currently available evidence. According to the most relevant findings of the present review, most of the existing neuropsychological, neuroimaging, and molecular evidence demonstrates the existence of neuroprogression, at least in a subgroup of BD patients. These studies mainly focused on the most relevant effects of neuroprogression on the course and outcome of BD. The main implications of this assumption are discussed in light of specific shortcomings/limitations, such as the inability to carry out a meta-analysis, the inclusion of studies with small sample sizes, retrospective study designs, and different longitudinal investigations at various time points. MDPI 2021-02-23 /pmc/articles/PMC7926350/ /pubmed/33672401 http://dx.doi.org/10.3390/brainsci11020276 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Serafini, Gianluca Pardini, Matteo Monacelli, Fiammetta Orso, Beatrice Girtler, Nicola Brugnolo, Andrea Amore, Mario Nobili, Flavio Neuroprogression as an Illness Trajectory in Bipolar Disorder: A Selective Review of the Current Literature |
title | Neuroprogression as an Illness Trajectory in Bipolar Disorder: A Selective Review of the Current Literature |
title_full | Neuroprogression as an Illness Trajectory in Bipolar Disorder: A Selective Review of the Current Literature |
title_fullStr | Neuroprogression as an Illness Trajectory in Bipolar Disorder: A Selective Review of the Current Literature |
title_full_unstemmed | Neuroprogression as an Illness Trajectory in Bipolar Disorder: A Selective Review of the Current Literature |
title_short | Neuroprogression as an Illness Trajectory in Bipolar Disorder: A Selective Review of the Current Literature |
title_sort | neuroprogression as an illness trajectory in bipolar disorder: a selective review of the current literature |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926350/ https://www.ncbi.nlm.nih.gov/pubmed/33672401 http://dx.doi.org/10.3390/brainsci11020276 |
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