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Structure-Based Virtual Screening of Tumor Necrosis Factor-α Inhibitors by Cheminformatics Approaches and Bio-Molecular Simulation

Tumor necrosis factor-α (TNF-α) is a drug target in rheumatoid arthritis and several other auto-immune disorders. TNF-α binds with TNF receptors (TNFR), located on the surface of several immunological cells to exert its effect. Hence, the use of inhibitors that can hinder the complex formation of TN...

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Detalles Bibliográficos
Autores principales:	Halim, Sobia Ahsan, Sikandari, Almas Gul, Khan, Ajmal, Wadood, Abdul, Fatmi, Muhammad Qaiser, Csuk, René, Al-Harrasi, Ahmed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926523/ https://www.ncbi.nlm.nih.gov/pubmed/33671607 http://dx.doi.org/10.3390/biom11020329

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