Cargando…

Residual Proviral Reservoirs: A High Risk for HIV Persistence and Driving Forces for Viral Rebound after Analytical Treatment Interruption

Antiretroviral therapy (ART) has dramatically suppressed human immunodeficiency virus (HIV) replication and become undetectable viremia. However, a small number of residual replication-competent HIV proviruses can still persist in a latent state even with lifelong ART, fueling viral rebound in HIV-i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Xiaolei, Xu, Huanbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926539/ https://www.ncbi.nlm.nih.gov/pubmed/33670027 http://dx.doi.org/10.3390/v13020335

Ejemplares similares

Increased Proviral DNA in Circulating Cells Correlates with Plasma Viral Rebound in Simian Immunodeficiency Virus-Infected Rhesus Macaques after Antiretroviral Therapy Interruption
por: Ziani, Widade, et al.
Publicado: (2021)

Rapid viral rebound after analytical treatment interruption in patients with very small HIV reservoir and minimal on‐going viral transcription
por: Pannus, Pieter, et al.
Publicado: (2020)

Transient viral replication during analytical treatment interruptions in SIV infected macaques can alter the rebound-competent viral reservoir
por: Immonen, Taina T., et al.
Publicado: (2021)

Immunological biomarkers predict HIV-1 viral rebound after treatment interruption
por: Hurst, Jacob, et al.
Publicado: (2015)

Episomal Viral cDNAs Identify a Reservoir That Fuels Viral Rebound after Treatment Interruption and That Contributes to Treatment Failure
por: Sharkey, Mark, et al.
Publicado: (2011)

Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV
por: Hill, Alison L., et al.
Publicado: (2016)

Correction: Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV
por: Hill, Alison L., et al.
Publicado: (2017)

Correction: Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV
Publicado: (2016)

Intact Proviral DNA Analysis of the Brain Viral Reservoir and Relationship to Neuroinflammation in People with HIV on Suppressive Antiretroviral Therapy
por: Gabuzda, Dana, et al.
Publicado: (2023)

Systemic and Intestinal Viral Reservoirs in CD4+ T Cell Subsets in Primary SIV Infection
por: Wang, Xiaolei, et al.
Publicado: (2021)

Compartmentalized HIV rebound in the central nervous system after interruption of antiretroviral therapy
por: Gianella, Sara, et al.
Publicado: (2016)

Phospholipid Metabolism Is Associated with Time to HIV Rebound upon Treatment Interruption
por: Giron, Leila B., et al.
Publicado: (2021)

A multidimensional HIV-1 persistence model for clonal expansion and viral rebound in vitro
por: Eshetu, Amare, et al.
Publicado: (2021)

Impact of Analytical Treatment Interruption on Burden and Diversification of HIV Peripheral Reservoir: A Pilot Study
por: Scutari, Rossana, et al.
Publicado: (2021)

The forces driving clonal expansion of the HIV-1 latent reservoir
por: Liu, Runxia, et al.
Publicado: (2020)

Early Initiation of Antiretroviral Therapy Following In Utero HIV Infection Is Associated With Low Viral Reservoirs but Other Factors Determine Viral Rebound
por: Millar, Jane R, et al.
Publicado: (2021)

Impact of HLA Class I Alleles on Timing of HIV Rebound After Antiretroviral Treatment Interruption
por: Park, You Jeong, et al.
Publicado: (2017)

Effect of analytical treatment interruption and reinitiation of antiretroviral therapy on HIV reservoirs and immunologic parameters in infected individuals
por: Clarridge, Katherine E., et al.
Publicado: (2018)

Impact of antiretroviral therapy in primary HIV infection on natural killer cell function and the association with viral rebound and HIV DNA following treatment interruption
por: Pace, Matthew, et al.
Publicado: (2022)

Cells producing residual viremia during antiretroviral treatment appear to contribute to rebound viremia following interruption of treatment
por: Aamer, Hadega A., et al.
Publicado: (2020)

Extensive characterization of HIV-1 reservoirs reveals links to plasma viremia before and during analytical treatment interruption
por: Cole, Basiel, et al.
Publicado: (2022)

Altered T‐cell subset distribution in the viral reservoir in HIV‐1‐infected individuals with extremely low proviral DNA (LoViReTs)
por: Gálvez, Cristina, et al.
Publicado: (2022)

A highly multiplexed droplet digital PCR assay to measure the intact HIV-1 proviral reservoir
por: Levy, Claire N., et al.
Publicado: (2021)

Viral and Latent Reservoir Persistence in HIV-1–Infected Patients on Therapy
por: Kim, Hwijin, et al.
Publicado: (2006)

HIV proviral DNA integration can drive T cell growth ex vivo
por: Yoon, John K., et al.
Publicado: (2020)

Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection
por: Colby, Donn, et al.
Publicado: (2018)

Mutations altering acetylated residues in the CTD of HIV-1 integrase cause defects in proviral transcription at early times after integration of viral DNA
por: Winans, Shelby, et al.
Publicado: (2020)

Models of SIV rebound after treatment interruption that involve multiple reactivation events
por: van Dorp, Christiaan H., et al.
Publicado: (2020)

Viral suppression and viral rebound among young adults living with HIV in Canada
por: Palmer, Alexis, et al.
Publicado: (2018)

Viral Rebound Kinetics Correlate with Distinct HIV Antibody Features
por: Bartsch, Yannic C., et al.
Publicado: (2021)

Expression of type I interferon-associated genes at antiretroviral therapy interruption predicts HIV virological rebound
por: Zacharopoulou, P., et al.
Publicado: (2022)

Proviral Turnover During Untreated HIV Infection Is Dynamic and Variable Between Hosts, Impacting Reservoir Composition on ART
por: Brooks, Kelsie, et al.
Publicado: (2021)

Ongoing HIV-1 evolution and reservoir reseeding in two elite controllers with genetically diverse peripheral proviral quasispecies
por: de Azevedo, Suwellen Sardinha Dias, et al.
Publicado: (2023)

Longitudinal comparison of HIV-1 plasma viral load and cellular proviral load
por: Schweitzer, Finja, et al.
Publicado: (2014)

Mucosal integrin α4β7 blockade fails to reduce the seeding and size of viral reservoirs in SIV‐infected rhesus macaques
por: Ziani, Widade, et al.
Publicado: (2021)

Cellular HIV Reservoirs and Viral Rebound from the Lymphoid Compartments of 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine (EFdA)-Suppressed Humanized Mice
por: Maidji, Ekaterina, et al.
Publicado: (2019)

Administration of a Toll-Like Receptor 9 Agonist Decreases the Proviral Reservoir in Virologically Suppressed HIV-Infected Patients
por: Winckelmann, Anni A., et al.
Publicado: (2013)

Determination of HIV-1 coreceptor tropism using proviral DNA in women before and after viral suppression
por: Baumann, Russell E, et al.
Publicado: (2015)

TLR7 agonist, N6-LS and PGT121 delayed viral rebound in SHIV-infected macaques after antiretroviral therapy interruption
por: Hsu, Denise C., et al.
Publicado: (2021)

STAT3 roles in viral infection: antiviral or proviral?
por: Chang, Zhangmei, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_3embm405lq0i7or454cd6fvp8f